KEGG   ENZYME: 4.2.3.86Help
Entry
EC 4.2.3.86                 Enzyme                                 

Name
7-epi-alpha-selinene synthase
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2E,6E)-farnesyl-diphosphate diphosphate-lyase (7-epi-alpha-selinene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = 7-epi-alpha-selinene + diphosphate [RN:R09886]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
7-epi-alpha-selinene [CPD:C20159];
diphosphate [CPD:C00013]
Comment
The recombinant enzyme from Vitis vinifera forms 49.5% (+)-valencene (cf. EC 4.2.3.73, valencene synthase) and 35.5% (-)-7-epi-alpha-selinene. Initial cyclization gives (+)-germacrene A in an enzyme bound form which is not released to the medium.
History
EC 4.2.3.86 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K14181  valencene/7-epi-alpha-selinene synthase
Genes
VVI: 100232955(VALCS) 100256880
Taxonomy
Reference
1  [PMID:15464152]
  Authors
Lucker J, Bowen P, Bohlmann J.
  Title
Vitis vinifera terpenoid cyclases: functional identification of two sesquiterpene synthase cDNAs encoding (+)-valencene synthase and (-)-germacrene D synthase and expression of mono- and sesquiterpene synthases in grapevine flowers and berries.
  Journal
Phytochemistry 65:2649-59 (2004)
DOI:10.1016/j.phytochem.2004.08.017
  Sequence
[vvi:100232955]
Reference
2  [PMID:19359488]
  Authors
Martin DM, Toub O, Chiang A, Lo BC, Ohse S, Lund ST, Bohlmann J
  Title
The bouquet of grapevine (Vitis vinifera L. cv. Cabernet Sauvignon) flowers arises from the biosynthesis of sesquiterpene volatiles in pollen grains.
  Journal
Proc Natl Acad Sci U S A 106:7245-50 (2009)
DOI:10.1073/pnas.0901387106
  Sequence
[vvi:100232955]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.86
IUBMB Enzyme Nomenclature: 4.2.3.86
ExPASy - ENZYME nomenclature database: 4.2.3.86
BRENDA, the Enzyme Database: 4.2.3.86

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