KEGG   ENZYME: 4.2.3.90Help
Entry
EC 4.2.3.90                 Enzyme                                 

Name
5-epi-alpha-selinene synthase;
8a-epi-alpha-selinene synthase;
NP1
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
(2Z,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, 5-epi-alpha-selinene-forming)
Reaction(IUBMB)
(2E,6E)-farnesyl diphosphate = 5-epi-alpha-selinene + diphosphate [RN:R09890]
Reaction(KEGG)
Substrate
(2E,6E)-farnesyl diphosphate [CPD:C00448]
Product
5-epi-alpha-selinene [CPD:C20163];
diphosphate [CPD:C00013]
Comment
Requires Mg2+. The enzyme forms 5-epi-alpha-selinene possibly via germecrene A or a 1,6-hydride shift mechanism.
History
EC 4.2.3.90 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K18109  5-epi-alpha-selinene synthase
Genes
ANA: alr4685
NPU: Npun_R3832
NOS: Nos7107_5352
AVA: Ava_1982
CALO: Cal7507_4737
Taxonomy
Reference
1  [PMID:18658271]
  Authors
Agger SA, Lopez-Gallego F, Hoye TR, Schmidt-Dannert C
  Title
Identification of sesquiterpene synthases from Nostoc punctiforme PCC 73102 and Nostoc sp. strain PCC 7120.
  Journal
J Bacteriol 190:6084-96 (2008)
DOI:10.1128/JB.00759-08
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.90
IUBMB Enzyme Nomenclature: 4.2.3.90
ExPASy - ENZYME nomenclature database: 4.2.3.90
BRENDA, the Enzyme Database: 4.2.3.90

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