KEGG   ENZYME: 4.2.3.99Help
Entry
EC 4.2.3.99                 Enzyme                                 

Name
labdatriene synthase;
OsKSL10 (gene name)
Class
Lyases;
Carbon-oxygen lyases;
Acting on phosphates
BRITE hierarchy
Sysname
9alpha-copalyl-diphosphate diphosphate-lyase [(12E)-9alpha-labda-8(17),12,14-triene-forming]
Reaction(IUBMB)
9alpha-copalyl diphosphate = (12E)-9alpha-labda-8(17),12,14-triene + diphosphate [RN:R09899]
Reaction(KEGG)
Substrate
9alpha-copalyl diphosphate [CPD:C11902]
Product
(12E)-9alpha-labda-8(17),12,14-triene [CPD:C20185];
diphosphate [CPD:C00013]
Comment
The enzyme from rice (Oryza sativa), expressed in Escherichia coli, also produces ent-sandaracopimara-8(14),15-diene from ent-copalyl diphosphate, another naturally occuring copalyl isomer in rice (cf. ent-sandaracopimaradiene synthase, EC 4.2.3.29).
History
EC 4.2.3.99 created 2012
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K14037  ent-sandaracopimaradiene/labdatriene synthase
Genes
OSA: 4352248
DOSA: Os12t0491800-01(Os12g0491800)
Taxonomy
Reference
1  [PMID:21323642]
  Authors
Morrone D, Hillwig ML, Mead ME, Lowry L, Fulton DB, Peters RJ
  Title
Evident and latent plasticity across the rice diterpene synthase family with potential implications for the evolution of diterpenoid metabolism in the cereals.
  Journal
Biochem J 435:589-95 (2011)
DOI:10.1042/BJ20101429
  Sequence
[osa:4352248]
Other DBs
ExplorEnz - The Enzyme Database: 4.2.3.99
IUBMB Enzyme Nomenclature: 4.2.3.99
ExPASy - ENZYME nomenclature database: 4.2.3.99
BRENDA, the Enzyme Database: 4.2.3.99

DBGET integrated database retrieval system