KEGG   ENZYME: 4.3.1.12Help
Entry
EC 4.3.1.12                 Enzyme                                 

Name
ornithine cyclodeaminase;
ornithine cyclase;
ornithine cyclase (deaminating);
L-ornithine ammonia-lyase (cyclizing)
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
L-ornithine ammonia-lyase (cyclizing; L-proline-forming)
Reaction(IUBMB)
L-ornithine = L-proline + NH3 [RN:R00671]
Reaction(KEGG)
Substrate
L-ornithine [CPD:C00077]
Product
L-proline [CPD:C00148];
NH3 [CPD:C00014]
Comment
Requires NAD+. The enzyme is a member of the mu-crystallin protein family [4]. The reaction is stimulated by the presence of ADP or ATP and is inhibited by O2 [2].
History
EC 4.3.1.12 created 1976
Pathway
ec00330  Arginine and proline metabolism
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K01750  ornithine cyclodeaminase
Genes
AFM: AFUA_6G08780
DDI: DDB_G0292894
PTI: PHATRDRAFT_35643
TPS: THAPSDRAFT_268092
TVA: TVAG_419590
ESA: ESA_01897
CTU: CTU_20900
CKO: CKO_02930
YPE: YPO4090
YPK: y4106
YPA: YPA_2995
YPN: YPN_3734
YPM: YP_3998
YPZ: YPZ3_3509
YPS: YPTB3900
YPY: YPK_0007
YPB: YPTS_4117
YEN: YE4168
ECA: ECA2039
PCT: PC1_2251
ETA: ETA_33140
EAM: EAMY_2207(Crym) EAMY_3527(ocd)
PAM: PANA_0886(ocd2)
PLU: plu3045
VVY: VV1563
PAE: PA4908
PAP: PSPA7_4377(eutC)
PFL: PFL_3641(arcB)
PAR: Psyc_1391(ocd)
SPL: Spea_1610
SHL: Shal_2647
PHA: PSHAb0543
FBL: Fbal_2395
CBU: CBU_1727(arcB)
CBS: COXBURSA331_A1919(arcB)
CBD: CBUD_0275(arcB) CBUD_1706
CBG: CbuG_0108(arcB)
CBC: CbuK_0280(arcB)
LPN: lpg2196
LPF: lpl2120
LPP: lpp2145
LPC: LPC_1659
LPA: lpa_03151
LLO: LLO_3403
MAH: MEALZ_0771(arcB)
FTW: FTW_0394
FTL: FTL_0578
FTA: FTA_0612
FTN: FTN_1444
FPH: Fphi_1230
CSA: Csal_2722
HEL: HELO_2879 HELO_3659(eutC)
CVI: CV_3249(ocd)
RPI: Rpic_3546
REH: H16_A0689(h16_A0689) H16_A1394(arcB) H16_A3673(h16_A3673) H16_B1881(h16_B1881)
BCN: Bcen_5804
BMU: Bmul_6144
BMJ: BMULJ_05386(ocd)
BPH: Bphy_3863
BAV: BAV0458(arcB) BAV0655 BAV1400
PNA: Pnap_3771
AJS: Ajs_0613
RTA: Rta_32100
EBA: ebA4164(ocd)
DAR: Daro_3361
PCA: Pcar_0765
DMA: DMR_28030(ocd)
DBA: Dbac_1146
SCL: sce2388(ocd)
HOH: Hoch_2639
ATU: Atu3949(arcB) Atu4758(arcB) Atu6016(ocd)
ARA: Arad_0078(ocdch1) Arad_10025(ocdch2) Arad_14151 Arad_7229(ocdch1) Arad_8390(ocdch2) Arad_8446
AVI: Avi_0068(arcB) Avi_5979(ocd) Avi_7398
RET: RHE_CH00058(ocdch1) RHE_CH02026(ocdch2) RHE_CH02594 RHE_PF00181(ocdf)
RLE: RL0060 RL3003(arcB2) RL3095(arcB1) RL4459(ocd) pRL120053(arcB3) pRL120751
BME: BMEII0397
BMF: BAB2_0338
BMB: BruAb2_0334(arcB)
BMS: BRA0899(arcB)
BOV: BOV_A0842(arcB)
BMR: BMI_II893(arcB)
RPC: RPC_1858
XAU: Xaut_3506
AZC: AZC_2010(ocd2)
MEX: Mext_2802
MEA: Mex_1p3003(arcB)
MDI: METDI3569(arcB)
MCH: Mchl_3030
MPO: Mpop_2926
RSP: RSP_0854
RCP: RCAP_rcc01475(ocd) RCAP_rcc02113(arcB1) RCAP_rcc03463(arcB2)
HNE: HNE_2590
HBA: Hbal_2672
RRU: Rru_A2867
BAN: BA_0902
BAR: GBAA_0902
BAT: BAS0854
BAI: BAA_1005
BCE: BC0906
BCA: BCE_0995
BCZ: BCE33L0803(arcB)
BCQ: BCQ_0989(arcB)
BCX: BCA_0953
BTK: BT9727_0800(arcB)
BTL: BALH_0814
BCL: ABC1182
SEP: SE0315
SER: SERP0192
SHA: SH2453
SSP: SSP2196
SCA: SCA_0751
MCL: MCCL_0345
LLM: llmg_1149(ocd)
LSL: LSL_1273
LCA: LSEI_0332
LFE: LAF_0928
THL: TEH_10850
CBO: CBO2575
CBA: CLB_2516
CBH: CLC_2447
CBY: CLM_2882
CBB: CLD_1990
CBI: CLJ_B2805
CBF: CLI_2638
BPB: bpr_I0537
OVA: OBV_37170
TMR: Tmar_0600
SAY: TPY_0444(ocd)
TOC: Toce_0467
ERH: ERH_1301(arcB)
CGL: NCgl1520(Cgl1582)
CGB: cg1784(ocd)
CGT: cgR_1630
CEF: CE1700 CE2115(ocd)
CJK: jk1979(ocd)
CAR: cauri_1343(arcB)
NFA: NFA_48620
SMA: SAVERM_1790(arcB1) SAVERM_3645(arcB2) SAVERM_5617(arcB3) SAVERM_7163(arcB4)
ART: Arth_3596
KRH: KRH_11610
XCE: Xcel_3303
PAC: PPA1289
MPH: MLP_02240 MLP_35350(ocd)
TCU: Tcur_1883
NML: Namu_3876
SEN: SACE_3017(arcB4) SACE_3879(arcB1) SACE_4281(arcB4)
AMD: AMED_0430(ocd) AMED_1481(ocd) AMED_4040(ocd) AMED_4796(ocd) AMED_6226(ocd)
PDX: Psed_1335
MIL: ML5_1763
CAI: Caci_1976
SNA: Snas_6348
AFO: Afer_1821
RCA: Rcas_3909
CAU: Caur_2849
HAU: Haur_1864
TRO: trd_0794
STI: Sthe_1236
MRB: Mrub_0429
TTR: Tter_0841
PUV: PUV_14860
PLM: Plim_0721
TDE: TDE2754(arcB)
TAI: Taci_0365
GAU: GAU_3810
PDI: BDI_1464
LBY: Lbys_1629
 » show all
Taxonomy
Reference
1  [PMID:4399881]
  Authors
Costilow RN, Laycock L.
  Title
Ornithine cyclase (deaminating). Purification of a protein that converts ornithine to proline and definition of the optimal assay conditions.
  Journal
J Biol Chem 246:6655-60 (1971)
Reference
2  [PMID:4373469]
  Authors
Muth WL, Costilow RN.
  Title
Ornithine cyclase (deaminating). II. Properties of the homogeneous enzyme.
  Journal
J Biol Chem 249:7457-62 (1974)
Reference
3  [PMID:10468639]
  Authors
Espineda CE, Linford AS, Devine D, Brusslan JA.
  Title
The AtCAO gene, encoding chlorophyll a oxygenase, is required for chlorophyll b synthesis in Arabidopsis thaliana.
  Journal
Proc Natl Acad Sci U S A 96:10507-11 (1999)
DOI:10.1073/pnas.96.18.10507
Reference
4  [PMID:15518536]
  Authors
Goodman JL, Wang S, Alam S, Ruzicka FJ, Frey PA, Wedekind JE.
  Title
Ornithine cyclodeaminase: structure, mechanism of action, and implications for the mu-crystallin family.
  Journal
Biochemistry 43:13883-91 (2004)
DOI:10.1021/bi048207i
  Sequence
[ppu:PP_3533]
Reference
5  [PMID:15103146]
  Authors
Alam S, Wang SC, Ruzicka FJ, Frey PA, Wedekind JE.
  Title
Crystallization and X-ray diffraction analysis of ornithine cyclodeaminase from Pseudomonas putida.
  Journal
Acta Crystallogr D Biol Crystallogr 60:941-4 (2004)
DOI:10.1107/S0907444904005256
  Sequence
[ppu:PP_3533]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.12
IUBMB Enzyme Nomenclature: 4.3.1.12
ExPASy - ENZYME nomenclature database: 4.3.1.12
BRENDA, the Enzyme Database: 4.3.1.12
CAS: 9054-76-6

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