KEGG   ENZYME: 4.3.1.27Help
Entry
EC 4.3.1.27                 Enzyme                                 

Name
threo-3-hydroxy-D-aspartate ammonia-lyase;
D-threo-3-hydroxyaspartate dehydratase
Class
Lyases;
Carbon-nitrogen lyases;
Ammonia-lyases
BRITE hierarchy
Sysname
threo-3-hydroxy-D-aspartate ammonia-lyase (oxaloacetate-forming)
Reaction(IUBMB)
threo-3-hydroxy-D-aspartate = oxaloacetate + NH3 [RN:R09683]
Reaction(KEGG)
Substrate
threo-3-hydroxy-D-aspartate [CPD:C19813]
Product
oxaloacetate [CPD:C00036];
NH3 [CPD:C00014]
Comment
A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Delftia sp. HT23, also has activity against L-threo-3-hydroxyaspartate, L-erythro-3-hydroxyaspartate, and D-serine. Different from EC 4.3.1.20, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC 4.3.1.16, threo-3-hydroxy-L-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Co2+ or Ni2+.
History
EC 4.3.1.27 created 2011
Orthology
K20757  threo-3-hydroxy-D-aspartate ammonia-lyase
Genes
DAC: Daci_0971
DEL: DelCs14_5553
DTS: BI380_19840
DHK: BO996_04935
Taxonomy
Reference
1  [PMID:20843822]
  Authors
Maeda T, Takeda Y, Murakami T, Yokota A, Wada M
  Title
Purification, characterization and amino acid sequence of a novel enzyme, D-threo-3-hydroxyaspartate dehydratase, from Delftia sp. HT23.
  Journal
J Biochem 148:705-12 (2010)
DOI:10.1093/jb/mvq106
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.3.1.27
IUBMB Enzyme Nomenclature: 4.3.1.27
ExPASy - ENZYME nomenclature database: 4.3.1.27
BRENDA, the Enzyme Database: 4.3.1.27

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