KEGG   ENZYME: 4.3.2.5Help
Entry
EC 4.3.2.5                  Enzyme                                 

Name
peptidylamidoglycolate lyase;
alpha-hydroxyglycine amidating dealkylase;
peptidyl-alpha-hydroxyglycine alpha-amidating lyase;
HGAD;
PGL;
PAL;
peptidylamidoglycolate peptidylamide-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
BRITE hierarchy
Sysname
peptidylamidoglycolate peptidyl-amide-lyase (glyoxylate-forming)
Reaction(IUBMB)
peptidylamidoglycolate = peptidyl amide + glyoxylate [RN:R03874]
Reaction(KEGG)
Substrate
peptidylamidoglycolate [CPD:C03303]
Product
peptidyl amide [CPD:C02179];
glyoxylate [CPD:C00048]
Comment
The enzyme acts on the product of the reaction catalysed by EC 1.14.17.3 peptidylglycine monooxygenase, thus removing a terminal glycine residue and leaving a des-glycine peptide amide.
History
EC 4.3.2.5 created 1992
Orthology
K18200  peptidylamidoglycolate lyase
Genes
HSA: 5066(PAM)
PTR: 461974(PAM)
PPS: 100970635(PAM)
GGO: 101148887(PAM)
PON: 100449730(PAM)
NLE: 100603954(PAM)
MCC: 707733(PAM)
MCF: 101926659(PAM)
CSAB: 103244283(PAM)
RRO: 104669199(PAM)
RBB: 108527716(PAM)
CJC: 100396001(PAM)
SBQ: 101034151(PAM)
MMU: 18484(Pam)
RNO: 25508(Pam)
CGE: 100770162(Pam)
NGI: 103738185(Pam)
HGL: 101716909(Pam)
CCAN: 109689129(Pam) 109698017
OCU: 100352005(PAM)
TUP: 102499925(PAM)
CFA: 479145(PAM)
AML: 100484534(PAM)
UMR: 103656467(PAM)
ORO: 101383156(PAM)
FCA: 101084598(PAM)
PTG: 102961161(PAM)
AJU: 106982276(PAM)
BTA: 280890(PAM)
BOM: 102271872(PAM)
BIU: 109562372(PAM)
PHD: 102335695(PAM)
CHX: 102190130(PAM)
OAS: 101112815(PAM)
SSC: 100526040(PAM)
CFR: 102509591(PAM)
CDK: 105103083(PAM)
BACU: 103008694(PAM)
LVE: 103088789(PAM)
OOR: 101274063(PAM)
ECB: 791244(PAM)
EPZ: 103555847(PAM)
EAI: 106831159(PAM)
MYB: 102257709(PAM)
MYD: 102752613(PAM)
HAI: 109394174(PAM)
RSS: 109445511(PAM)
PALE: 102894575(PAM)
LAV: 100655604(PAM)
TMU: 101356870
MDO: 100030601(PAM)
SHR: 105749257(PAM)
OAA: 100073355(PAM)
GGA: 427274(PAM)
CJO: 107306340(PAM)
APLA: 101795983(PAM)
ACYG: 106043740(PAM)
TGU: 100227923(PAM)
GFR: 102039677(PAM)
FAB: 101821831(PAM)
PHI: 102114573(PAM)
PMAJ: 107215969(PAM)
CCW: 104693194(PAM)
FPG: 101920860(PAM)
FCH: 102052743(PAM)
CLV: 102087217(PAM)
EGZ: 104135057(PAM)
ASN: 102374229(PAM)
AMJ: 102559599(PAM)
PSS: 102462977(PAM)
CMY: 102946187(PAM)
CPIC: 101942761(PAM)
ACS: 100562563(pam)
PVT: 110079386(PAM)
PBI: 103055156(PAM) 103062674
GJA: 107121208(PAM)
XLA: 379207(pam.L) 397736(pam.S)
XTR: 100170159(pam)
NPR: 108797815(PAM)
DRE: 570822(pam)
SGH: 107558261(pam) 107560403
IPU: 108277198(pam)
AMEX: 103031431(pam)
TRU: 101062613(pam)
LCO: 104938829(pam) 104939677
NCC: 104955430
MZE: 101484633(pam)
OLA: 101164528(pam)
XMA: 102227462(pam)
PRET: 103473165(pam)
NFU: 107395057(pam)
CSEM: 103389193(pam)
LCF: 108877750(pam)
HCQ: 109530660(pam)
BPEC: 110161642(pam)
SASA: 106571984(pam)
ELS: 105020460(pam)
SFM: 108929922(pam)
LCM: 102348819(PAM)
CMK: 103178402(pam)
CIN: 100186640
SPU: 579753
DME: Dmel_CG12130(Pal1) Dmel_CG5472(Pal2)
DSI: Dsimw501_GD10702(Dsim_GD10702) Dsimw501_GD11785(Dsim_GD11785)
AME: 408568
BIM: 100741817
BTER: 100644430
TCA: 657814
DPA: 109540523
NVL: 108563948
TUT: 107370625
CEL: CELE_F21F3.1(pgal-1) CELE_T19B4.1(pamn-1)
BMY: Bm1_41845
OBI: 106870427
LAK: 106162187
EGL: EGR_00446
ADF: 107333635
OLU: OSTLU_15206(PAM1)
APRO: F751_4456
 » show all
Taxonomy
Reference
1  [PMID:2207061]
  Authors
Katopodis AG, Ping D, May SW.
  Title
A novel enzyme from bovine neurointermediate pituitary catalyzes dealkylation of alpha-hydroxyglycine derivatives, thereby functioning sequentially with peptidylglycine alpha-amidating monooxygenase in peptide amidation.
  Journal
Biochemistry 29:6115-20 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.5
IUBMB Enzyme Nomenclature: 4.3.2.5
ExPASy - ENZYME nomenclature database: 4.3.2.5
BRENDA, the Enzyme Database: 4.3.2.5
CAS: 131689-50-4

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