KEGG   ENZYME: 4.3.3.2Help
Entry
EC 4.3.3.2                  Enzyme                                 

Name
strictosidine synthase;
strictosidine synthetase;
STR;
3-alpha(S)-strictosidine tryptamine-lyase
Class
Lyases;
Carbon-nitrogen lyases;
Amine-lyases
BRITE hierarchy
Sysname
3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)
Reaction(IUBMB)
3-alpha(S)-strictosidine + H2O = tryptamine + secologanin [RN:R03738]
Reaction(KEGG)
Substrate
3-alpha(S)-strictosidine [CPD:C03470];
H2O [CPD:C00001]
Product
tryptamine [CPD:C00398];
secologanin [CPD:C01852]
Comment
Catalyses a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine [4,5]. Involved in the biosynthesis of the monoterpenoid indole alkaloids.
History
EC 4.3.3.2 created 1990
Pathway
ec00901  Indole alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01757  strictosidine synthase
Genes
DME: Dmel_CG11833(Ssl2)
ATH: AT1G74000(SS3) AT1G74010 AT1G74020(SS2)
ALY: ARALYDRAFT_476540 ARALYDRAFT_476541 ARALYDRAFT_476542
CSAT: 104702105 104702108 104713027 104713028 104713029 104713030 104751270 104751271 104751272
EUS: EUTSA_v10018851mg EUTSA_v10018854mg
BRP: 103830721 103831875 103831876 103852873 103852875 103852877
BNA: 106354360 106357261 106379410 106379465 106379467 106381362 106405344
BOE: 106299100 106299368 106299590 106299599 106322831 106325777 106326024
THJ: 104808295
RHA: RHA1_ro00912
LIL: LA_4215
LIC: LIC_13366
LBL: LBL_0235
 » show all
Taxonomy
Reference
1  [PMID:510306]
  Authors
Treimer JF, Zenk MH.
  Title
Purification and properties of strictosidine synthase, the key enzyme in indole alkaloid formation.
  Journal
Eur J Biochem 101:225-33 (1979)
DOI:10.1111/j.1432-1033.1979.tb04235.x
Reference
2  [PMID:7763429]
  Authors
Kutchan TM.
  Title
Strictosidine: from alkaloid to enzyme to gene.
  Journal
Phytochemistry 32:493-506 (1993)
DOI:10.1016/S0031-9422(00)95128-8
Reference
3  [PMID:7887913]
  Authors
de Waal A, Meijer AH, Verpoorte R.
  Title
Strictosidine synthase from Catharanthus roseus: purification and characterization of multiple forms.
  Journal
Biochem J 306 ( Pt 2):571-80 (1995)
Reference
4  [PMID:16133216]
  Authors
Ruppert M, Woll J, Giritch A, Genady E, Ma X, Stockigt J.
  Title
Functional expression of an ajmaline pathway-specific esterase from Rauvolfia in a novel plant-virus expression system.
  Journal
Planta 222:888-98 (2005)
DOI:10.1007/s00425-005-0031-0
Reference
5  [PMID:16481164]
  Authors
McCoy E, Galan MC, O'Connor SE.
  Title
Substrate specificity of strictosidine synthase.
  Journal
Bioorg Med Chem Lett 16:2475-8 (2006)
DOI:10.1016/j.bmcl.2006.01.098
Reference
6  [PMID:16531499]
  Authors
Ma X, Panjikar S, Koepke J, Loris E, Stockigt J.
  Title
The structure of Rauvolfia serpentina strictosidine synthase is a novel six-bladed beta-propeller fold in plant proteins.
  Journal
Plant Cell 18:907-20 (2006)
DOI:10.1105/tpc.105.038018
Other DBs
ExplorEnz - The Enzyme Database: 4.3.3.2
IUBMB Enzyme Nomenclature: 4.3.3.2
ExPASy - ENZYME nomenclature database: 4.3.3.2
BRENDA, the Enzyme Database: 4.3.3.2
CAS: 69669-72-3

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