KEGG   ENZYME: 4.4.1.11Help
Entry
EC 4.4.1.11                 Enzyme                                 

Name
methionine gamma-lyase;
L-methioninase;
methionine lyase;
methioninase;
methionine dethiomethylase;
L-methionine gamma-lyase;
L-methionine methanethiol-lyase (deaminating)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)
Reaction(IUBMB)
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate (overall reaction) [RN:R00654];
(1a) L-methionine = methanethiol + 2-aminobut-2-enoate [RN:R08635];
(1b) 2-aminobut-2-enoate = 2-iminobutanoate (spontaneous);
(1c) 2-iminobutanoate + H2O = 2-oxobutanoate + NH3 (spontaneous)
Reaction(KEGG)
R00654 R08635;
(other) R04770
Show
Substrate
L-methionine [CPD:C00073];
H2O [CPD:C00001];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate [CPD:C20905]
Product
methanethiol [CPD:C00409];
NH3 [CPD:C00014];
2-oxobutanoate [CPD:C00109];
2-aminobut-2-enoate [CPD:C17234];
2-iminobutanoate [CPD:C20905]
Comment
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-sulfur bond, releasing methanethiol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form 2-oxobutanoate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme is involved in L-methionine catabolism.
History
EC 4.4.1.11 created 1976
Pathway
ec00270  Cysteine and methionine metabolism
ec00450  Selenocompound metabolism
Orthology
K01761  methionine-gamma-lyase
Genes
RSS: 109441294
ATH: AT1G64660(MGL)
ALY: ARALYDRAFT_681961
CRB: 17896242
CSAT: 104714835 104753135 104774542
BRP: 103838186
BNA: 106366448 106368984
BOE: 106313580
THJ: 104817406
CPAP: 110814980
CIT: 102609475
TCC: 18605977
EGR: 104441613
LJA: Lj0g3v0108489.1(Lj0g3v0108489.1)
FVE: 101304344
PPER: 18776049
PMUM: 103337840
PAVI: 110758899
ZJU: 107430088
CMO: 103482860 103490704(MGL)
RCU: 8288843
JCU: 105645580
HBR: 110633917
VVI: 100253026
CANN: 107863655
INI: 109146474
DCR: 108209382
BVG: 104892621
SOE: 110796239
NNU: 104593448
OSA: 4349123
DOSA: Os10t0517500-02(Os10g0517500)
OBR: 102715888
BDI: 100831152
ATS: 109778033(LOC109778033)
SBI: 8065691
SITA: 101759989
PDA: 103708467
EGU: 105043483
ATR: 18438907
EFE: EFER_3533
CKO: CKO_04984
CBRA: A6J81_18295(megL)
CWE: CO701_23145(megL)
CYO: CD187_01010(megL)
CIF: AL515_00215(megL)
CIE: AN232_05535(megL)
SPE: Spro_0798
SRL: SOD_c06720(mdeA)
SPLY: Q5A_003525(mdeA)
SMAF: D781_0759
SMAR: SM39_0113
SERF: L085_00335
RAA: Q7S_01065
ETA: ETA_08500(mdeA)
EPY: EpC_08340(mdeA)
EPR: EPYR_00883(mdeA)
EAM: EAMY_2799(mdeA3)
EAY: EAM_0782
EBI: EbC_07760(mdeA)
ERJ: EJP617_02670(mdeA)
EGE: EM595_0772(mdeA)
PAM: PANA_0759(mdeA)
PLF: PANA5342_3548(mdeA)
PAJ: PAJ_0107(mdeA)
PVA: Pvag_0171(mdeA)
TPTY: NCTC11468_00993(mdeA)
PMR: PMI1248 PMI2254(mdeA)
PSI: S70_05720
PSX: DR96_248(megL)
PRG: RB151_035050(mdeA_2)
PHEI: NCTC12003_00711(mdeA_2) NCTC12003_00938(mdeA_3)
PPU: PP_1308(mdeA)
PPF: Pput_4416
PPT: PPS_4385
PPI: YSA_03044
PPX: T1E_0568(mdeA)
PPUH: B479_22055
PPUT: L483_27125
PPUN: PP4_08180(mdeA)
PPUD: DW66_4775
PMON: X969_21595
PMOT: X970_21230
PFL: PFL_3514(megL)
PPRC: PFLCHA0_c35550(mdeA2)
PPRO: PPC_3668(megL)
PFS: PFLU_2558
PFC: PflA506_2292(megL)
PFW: PF1751_v1c22100(megL)
PEN: PSEEN4515(mdeA)
PSEC: CCOS191_4423(mdeA)
PSOS: POS17_3652(megL)
PANR: A7J50_2443
PSIL: PMA3_09645
SON: SO_1812(mdeA)
SDN: Sden_2521
SFR: Sfri_1369
SAZ: Sama_1242
SLO: Shew_2491
SSE: Ssed_1559
SPL: Spea_2664
SHL: Shal_2751
SWD: Swoo_3095
SWP: swp_3243
SVO: SVI_2979(mdeA)
SHF: CEQ32_07180(megL)
SPSW: Sps_01864
SBJ: CF168_07705(megL)
ILO: IL0726
IPI: CEW91_07090(megL)
IDI: CWC33_12550(megL)
IDT: C5610_05195(megL)
CPS: CPS_1705(megL)
COLA: DBO93_05165(megL)
PHA: PSHAa2044(mdeA)
PSM: PSM_A2108(mdeA)
PSEO: OM33_12860
PSPO: PSPO_a2130
PART: PARC_a1233
PSEN: PNC201_11450(mdeA)
GPS: C427_1477
FBL: Fbal_2581
SAGA: M5M_10785
MICC: AUP74_02846(mdeA_2)
NHL: Nhal_2668
NWA: Nwat_2265
GAI: IMCC3135_27095(mdeA)
HCO: LOKO_03647(mdeA_2)
KKO: Kkor_1449
KGE: TQ33_1177
KPD: CW740_06770(megL)
AHA: AHA_1947
ASA: ASA_2347(mdeA)
AVR: B565_1630
AMED: B224_1958
ASR: WL1483_3315(mdeA)
PSE: NH8B_3749
BMA: BMAA1317
BMAL: DM55_4204
BMAE: DM78_3336
BMAQ: DM76_4904
BMAI: DM57_10460
BMAF: DM51_4972
BMAZ: BM44_4167
BMAB: BM45_3289
BPS: BPSS0913
BPSE: BDL_4202
BPSM: BBQ_5224
BPSU: BBN_4372
BPSD: BBX_6042
BPK: BBK_3525
BPSH: DR55_4423
BPSA: BBU_5118
BPSO: X996_4149
BUT: X994_6212
BTQ: BTQ_4771
BTJ: BTJ_3403
BTZ: BTL_4251
BTD: BTI_5732
BTV: BTHA_3706
BTHE: BTN_3440
BTHM: BTRA_4191
BTHA: DR62_3513
BTHL: BG87_4227
BOK: DM82_5086
BOC: BG90_5509
BCED: DM42_6446(mdeA) DM42_6464(megL)
BCON: NL30_23940
BMEC: WJ16_10180
BSTG: WT74_06185
BGU: KS03_3972
BGO: BM43_6452
BUL: BW21_5419
BPH: Bphy_5613
BTRM: SAMEA390648700106(cysD1_1)
AXY: AXYL_03670(megL1) AXYL_04293(megL2)
AXX: ERS451415_03310(mdeA_3) ERS451415_04055(mdeA_4) ERS451415_06128(mdeA_5)
RGE: RGE_14420(metB)
DML: Dmul_38920(mdeA)
DAT: HRM2_06160(mdeA)
BBAT: Bdt_1366
BBW: BDW_02265
BBAC: EP01_16855
BEX: A11Q_1882
MLO: mll1618
AMIH: CO731_03996(mdeA_2)
SME: SMc01666(mdeA)
SMX: SM11_chr0980(mdeA)
SMI: BN406_02102(mdeA)
SMEL: SM2011_c01666(mdeA)
SMER: DU99_12745
SFH: SFHH103_02084(mdeA) SFHH103_06399(metB)
SFD: USDA257_c19900(mdeA1) USDA257_c26390(mdeA2) USDA257_c45790(mdeA4)
EAD: OV14_3720
ATU: Atu3806(mdeA)
ATF: Ach5_28850(mdeA)
AGC: BSY240_1706(megL)
RET: RHE_PF00019(mdeAf)
REC: RHECIAT_PC0000024(mdeAc)
REL: REMIM1_PF00020(mdeA)
RLE: pRL120373
RLG: Rleg_4740
RHL: LPU83_0713(mdeA)
RGA: RGR602_CH00598(mdeA)
RHN: AMJ98_PE00022(mdeA)
RHX: AMK02_PD00020(mdeA)
SHZ: shn_29290
BME: BMEI0103
BMEL: DK63_1331
BMEE: DK62_1615
BMF: BAB1_1966
BABO: DK55_1901
BABR: DO74_2073
BABT: DK49_1659
BABB: DK48_218
BABU: DK53_1886
BABS: DK51_1656
BABC: DO78_1806
BMS: BR1965
BMT: BSUIS_A1805(mdeA)
BSZ: DK67_397
BCS: BCAN_A2010(mdeA)
BCAR: DK60_1943
BCAS: DA85_09435
BMR: BMI_I1987
BPP: BPI_I2024
BPV: DK65_1564
OAN: Oant_1017
OAH: DR92_558
BJA: bll5911(mdeA)
BRS: S23_23430(mdeA)
AOL: S58_63120
BRAD: BF49_5736
RPB: RPB_0450
NHA: Nham_1875
MET: M446_0251
MNO: Mnod_5459
MAQU: Maq22A_c06180(metC)
MSC: BN69_2744
HDI: HDIA_4487(mdeA_3)
CCR: CC_3168
CSE: Cseg_0794
SIL: SPOA0318(megL)
RDE: RD1_2640(mdeA)
PGA: PGA1_c16600(mdeA)
PGL: PGA2_c16430(mdeA)
PGD: Gal_01682
PHP: PhaeoP97_01668(mdeA)
PPIC: PhaeoP14_01562(mdeA)
OAT: OAN307_c19440(mdeA)
OTM: OSB_03240(mdeA_1)
SPSE: SULPSESMR1_04836(mgl)
HNE: HNE_3448(mdeA)
NAR: Saro_3503
SAL: Sala_0483
SPHP: LH20_02310
SMAZ: LH19_17190
SGI: SGRAN_1273(mdeA)
SPHU: SPPYR_2665
SWI: Swit_0856
SPHD: HY78_22410
SPHM: G432_10705
STAX: MC45_15050
SPHI: TS85_22600
SSAN: NX02_26165
SPKC: KC8_12870
SSY: SLG_06080
SPMI: K663_00230
SPHR: BSY17_1391
SINB: SIDU_15670
SPHT: K426_00235
SFLA: SPHFLASMR4Y_01598(mgl)
BLAS: BSY18_2620
ELI: ELI_09475
AAY: WYH_03075(mdeA_1)
ANH: A6F65_00999(mdeA)
ADO: A6F68_01688(mdeA)
RRF: F11_00495
TMO: TMO_2955(mdeA) TMO_c0393
TXI: TH3_18170
MGM: Mmc1_0771
BHA: BH0799
BAN: BA_4906(megL)
BAR: GBAA_4906(megL)
BAT: BAS4553
BAH: BAMEG_4939(megL)
BAI: BAA_4918(megL)
BANT: A16_48990
BANR: A16R_49630
BANS: BAPAT_4705
BANV: DJ46_3570(megL)
BCE: BC4654
BCA: BCE_4791(megL)
BCZ: BCE33L4398(megL)
BCR: BCAH187_A4789(megL)
BCB: BCB4264_A4763(megL)
BCU: BCAH820_4772(megL)
BCG: BCG9842_B0472(megL)
BCQ: BCQ_4470(megL)
BCX: BCA_4769(megL)
BAL: BACI_c46500(megL)
BNC: BCN_4563
BCF: bcf_23350
BCER: BCK_11925
BTK: BT9727_4388(megL)
BTL: BALH_4232(megL)
BTB: BMB171_C4294(megL)
BTT: HD73_4952
BTHI: BTK_24425
BTC: CT43_CH4676(megL)
BTM: MC28_3932
BTG: BTB_c48070(mdeA1)
BTI: BTG_25590
BTW: BF38_416(megL)
BWW: bwei_0238(megL)
BMYO: BG05_1385(megL)
BMYC: DJ92_1747(megL)
BCL: ABC3938
BMQ: BMQ_1531(megL)
BMD: BMD_1512(megL)
BMH: BMWSH_3698(megL)
BMEG: BG04_3823(megL)
BMET: BMMGA3_02500(mdeA1) BMMGA3_04825(mdeA2)
BEO: BEH_02565
BKW: BkAM31D_14135(mdeA_2)
BBEV: BBEV_1559
OIH: OB3046
GGH: GHH_c13490(metB)
ANM: GFC28_408(megL)
AAMY: GFC30_1746(megL)
ANL: GFC29_1216(megL)
BSE: Bsel_2028
BBE: BBR47_55420(megL)
PRI: PRIO_4194(mdeA)
JEO: JMA_24670
LFB: C1X05_09075(megL)
CTC: CTC_02530
CNO: NT01CX_0149(megL)
CBO: CBO0029(mdeA)
CBA: CLB_0039(megL)
CBH: CLC_0047(megL)
CBY: CLM_0033(megL)
CBL: CLK_3163(megL)
CBB: CLD_0789(megL)
CBI: CLJ_B0032(megL)
CBF: CLI_0043(megL)
CBM: CBF_0034(megL)
CKR: CKR_1517
CPAS: Clopa_2222
CPAT: CLPA_c22830(metB)
CPAE: CPAST_c22830(metB)
CLD: CLSPO_c00310(mdeA1)
CTYK: CTK_C14100(metB)
RBR: RBR_07900
CPRO: CPRO_06450(mdeA_1)
CDF: CD630_35770(mdeA)
PDC: CDIF630_03898(mdeA)
CDC: CD196_3369(mdeA)
CDL: CDR20291_3415(mdeA)
PDF: CD630DERM_35770(mdeA)
EAC: EAL2_c15840(mdeA2)
CST: CLOST_2039(megL)
STH: STH832
SGY: Sgly_0928
OVA: OBV_33660
THX: Thet_1076
TAE: TepiRe1_0485(cysA) TepiRe1_0932(mdeA) TepiRe1_2071(mdeA)
TOC: Toce_1559
CAD: Curi_c20890(metC)
MED: MELS_1685
MEG: DKB62_07305(megL)
SRI: SELR_27570(megL)
MPF: MPUT_0302(megL)
MPUT: MPUT9231_4470(megL)
ROP: ROP_72220
GBR: Gbro_1986
GOR: KTR9_1917
SCO: SCO1294(SCBAC36F5.05c)
SMA: SAVERM_7062(mgl)
SGR: SGR_6256
SGB: WQO_04305
SCT: SCAT_0814
SHY: SHJG_2707
SALB: XNR_5540
SALS: SLNWT_6620
SFI: SFUL_827
SPRI: SPRI_6266
SRW: TUE45_01664(mdeA)
SLE: sle_58030(sle_58030)
STRD: NI25_32730
SMAL: SMALA_6841
SLX: SLAV_09185(mdeA)
SFK: KY5_0423c
KSK: KSE_61340
ARM: ART_3218
LMOI: VV02_15015
SERJ: SGUI_1485
BLIN: BLSMQ_1904
NDK: I601_0378(metC)
KFL: Kfla_6932
TCU: Tcur_3821
SEN: SACE_3377(megL)
AMD: AMED_7738(metB)
AMN: RAM_39755
AMM: AMES_7621(metB)
AMZ: B737_7621(metB)
AOI: AORI_6522
PDX: Psed_3633
PSEE: FRP1_14915
PSEH: XF36_15135
SESP: BN6_30650
KAL: KALB_8039
ALL: CRK59531
MIL: ML5_3909
CAI: Caci_5539
BDE: BDP_0406(metB)
BDN: BBDE_0388
BBI: BBIF_1569
BBF: BBB_1603(mdeA)
RCA: Rcas_3672
CAU: Caur_3273
CAG: Cagg_0621
TRO: trd_0392
ATM: ANT_30680
ABAT: CFX1CAM_0173(mdeA)
DRA: DR_0921
DGE: Dgeo_0011
TRA: Trad_2517
TTR: Tter_2737
IPA: Isop_0581
SACI: Sinac_3527
TDE: TDE2200(megL)
TPED: TPE_1938(megL)
ABAC: LuPra_03204(mdeA_2)
FNU: FN1419
FPD: CTM68_08760(megL)
FMO: C4N19_01930(megL) C4N19_04590(megL) C4N19_06325(megL)
FGO: C4N16_00425(megL)
GAU: GAU_2561
BACC: BRDCF_p346(mdeA)
PGI: PG_0343(megL)
PGN: PGN_1618
PGT: PGTDC60_1459(megL)
PCRE: NCTC12858_01232(mdeA)
RMR: Rmar_1177
GFO: GFO_2175(mdeA)
GFL: GRFL_0228
FJO: Fjoh_2131
FJG: BB050_00513(mccB)
FPS: FP1733
FIN: KQS_04150
MARM: YQ22_15725
CBAL: M667_14830
CBAT: M666_14780
DDO: I597_2560(mccB_2)
MLT: VC82_2945
NDO: DDD_1693
CHZ: CHSO_1583
CTAK: 4412677_00856(mdeA_1)
WIN: WPG_3443
KOS: KORDIASMS9_03086(mgl)
MARF: CJ739_3650
IAL: IALB_0448(metZ) IALB_2699
MRO: MROS_2426
KOL: Kole_0404
MINF: MESINF_2230(mdeA)
LFC: LFE_0401
MAC: MA_2532(mgl)
MBAR: MSBR2_1226
MBAK: MSBR3_0524
MMA: MM_3085
MMAC: MSMAC_2948
METM: MSMTP_1779
MHOR: MSHOH_2546
MBN: Mboo_1995
MPL: Mpal_0648
BARB: AOA66_1742
 » show all
Taxonomy
Reference
1  [PMID:4720797]
  Authors
Kreis W, Hession C.
  Title
Isolation and purification of L-methionine-alpha-deamino-gamma-mercaptomethane-lyase (L-methioninase) from Clostridium sporogenes.
  Journal
Cancer Res 33:1862-5 (1973)
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.11
IUBMB Enzyme Nomenclature: 4.4.1.11
ExPASy - ENZYME nomenclature database: 4.4.1.11
UM-BBD (Biocatalysis/Biodegradation Database): 4.4.1.11
BRENDA, the Enzyme Database: 4.4.1.11
CAS: 42616-25-1

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