KEGG   ENZYME: 4.4.1.17Help
Entry
EC 4.4.1.17                 Enzyme                                 

Name
holocytochrome-c synthase;
cytochrome c heme-lyase;
holocytochrome c synthetase;
holocytochrome-c apocytochrome-c-lyase
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
holocytochrome-c apocytochrome-c-lyase (heme-forming)
Reaction(IUBMB)
holocytochrome c = apocytochrome c + heme [RN:R02480]
Reaction(KEGG)
Substrate
holocytochrome c [CPD:C00524]
Product
apocytochrome c [CPD:C02248];
heme [CPD:C00032]
Comment
In the reverse direction, the enzyme catalyses the attachment of heme to two cysteine residues in the protein, forming thioether links.
History
EC 4.4.1.17 created 1990
Pathway
ec00860  Porphyrin and chlorophyll metabolism
Orthology
K01764  cytochrome c heme-lyase
Genes
HSA: 3052(HCCS)
PTR: 465489(HCCS)
PPS: 100982890
GGO: 101144727
PON: 100171510(HCCS)
NLE: 100581904
MCC: 709878(HCCS)
MCF: 102130747
CSAB: 103231586(HCCS)
RRO: 104668988
RBB: 108521718
CJC: 100390250(HCCS)
SBQ: 101031607
MMU: 15159(Hccs)
RNO: 317444(Hccs)
CGE: 100763541
NGI: 103749976
HGL: 101700661
CCAN: 109700658
OCU: 100356413
TUP: 102502642
CFA: 480834(HCCS)
AML: 100468148
UMR: 103668095
ORO: 101380132
FCA: 101085440
PTG: 102965890
AJU: 106971058
BTA: 506250(HCCS)
BOM: 102285652
BIU: 109555378
PHD: 102327319
CHX: 102172983
OAS: 101118248
SSC: 100524598
CFR: 102518576
CDK: 105100574
BACU: 103012604
LVE: 103085147
OOR: 101283199
ECB: 100053680(HCCS)
EPZ: 103554122
EAI: 106840188
MYB: 102241906
MYD: 102773356
HAI: 109387356
RSS: 109455050
PALE: 102896586
LAV: 100667706
TMU: 101350601
MDO: 100018151
OAA: 100080272
GGA: 424482(HCCS)
MGP: 100543527
CJO: 107317472
APLA: 101802937
ACYG: 106039420
TGU: 100224495
GFR: 102033497
FAB: 101813169
PHI: 102102125
PMAJ: 107208137
CCAE: 111932775
CCW: 104695360
FPG: 101919200
FCH: 102059144
CLV: 102098938
EGZ: 104134000
ASN: 102384511
AMJ: 102575147(HCCS)
PSS: 102456344
CMY: 102929734
CPIC: 101941245
ACS: 100566296
PVT: 110076505
PBI: 103050626
GJA: 107120140
XLA: 380272(hccs.L) 447038(hccs.S)
XTR: 448226(hccs)
NPR: 108791802
DRE: 436771(hccsa.1) 58016(hccsb)
TRU: 101061825
LCO: 104935677
NCC: 104967228
MZE: 101478944
XMA: 102227589
PRET: 103482232
NFU: 107382602
KMR: 108249834
CSEM: 103376865
LCF: 108898461
SDU: 111220508
HCQ: 109530268
BPEC: 110174639
MALB: 109965559
SASA: 106578494(CCHL) 106599140
ELS: 105022587
SFM: 108935039
LCM: 102361996
CMK: 103174637
CIN: 100181858
SPU: 583826
APLC: 110977445
DME: Dmel_CG6022(Cchl)
DSI: Dsimw501_GD18482(Dsim_GD18482)
MDE: 101892476
AAG: 5564809
AME: 408968
BIM: 100749146
BTER: 100642708
SOC: 105207876
AEC: 105151758
ACEP: 105622130
PBAR: 105425111
HST: 105192514
DQU: 106749061
CFO: 105253198
LHU: 105668986
PGC: 109851809
PCF: 106785851
NVI: 100120531
TCA: 655015
DPA: 109539650
NVL: 108564329
BMOR: 101739921
PMAC: 106715065
PRAP: 110999891
HAW: 110384079
API: 100168949
DNX: 107163790
CLEC: 106671883
ZNE: 110828439
FCD: 110844792
TUT: 107359978
CEL: CELE_T06D8.6(cchl-1)
CBR: CBG02944(Cbr-cchl-1)
BMY: Bm1_07670
CRG: 105334822
MYI: 110466583
OBI: 106881756
SHX: MS3_07992
EGL: EGR_02170
EPA: 110235145
AQU: 100632281
SCE: YAL039C(CYC3) YKL087C(CYT2)
KMX: KLMA_60164(CYT2) KLMA_80238(CYC3)
NCS: NCAS_0A07580(NCAS0A07580) NCAS_0H03340(NCAS0H03340)
NDI: NDAI_0C00320(NDAI0C00320) NDAI_0H01140(NDAI0H01140)
TPF: TPHA_0N00340(TPHA0N00340) TPHA_0N01700(TPHA0N01700)
TBL: TBLA_0C00880(TBLA0C00880) TBLA_0F01590(TBLA0F01590)
TDL: TDEL_0B07380(TDEL0B07380) TDEL_0H04130(TDEL0H04130)
KAF: KAFR_0K00500(KAFR0K00500)
PIC: PICST_33494(CYC3) PICST_37815(CYT2)
SLB: AWJ20_1725(CYT2) AWJ20_3176(CYC3)
NCR: NCU05601(cyt-2) NCU08138
NTE: NEUTE1DRAFT131836(NEUTE1DRAFT_131836) NEUTE1DRAFT86485(NEUTE1DRAFT_86485)
BFU: BCIN_01g03060(Bccyc3)
ANG: ANI_1_1608184(An04g01535) ANI_1_44124(An14g00240)
TVE: TRV_00324
ABP: AGABI1DRAFT111393(AGABI1DRAFT_111393) AGABI1DRAFT111983(AGABI1DRAFT_111983)
ABV: AGABI2DRAFT193225(AGABI2DRAFT_193225) AGABI2DRAFT216724(AGABI2DRAFT_216724)
MGL: MGL_3980
DDI: DDB_G0275895(cchl)
DFA: DFA_07027(cchl)
PCB: PCHAS_060440(PC000789.03.0) PCHAS_144150(PC300668.00.0)
TPV: TP02_0784
BBO: BBOV_III011500(17.m07981) BBOV_IV008890(23.m05868)
SMIN: v1.2.025477.t1(symbB.v1.2.025477.t1) v1.2.033285.t1(symbB.v1.2.033285.t1)
 » show all
Taxonomy
Reference
1  [PMID:3034577]
  Authors
Dumont ME, Ernst JF, Hampsey DM, Sherman F.
  Title
Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae.
  Journal
EMBO J 6:235-41 (1987)
  Sequence
[sce:YAL039C]
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.17
IUBMB Enzyme Nomenclature: 4.4.1.17
ExPASy - ENZYME nomenclature database: 4.4.1.17
BRENDA, the Enzyme Database: 4.4.1.17
CAS: 75139-03-6

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