KEGG   ENZYME: 4.4.1.20Help
Entry
EC 4.4.1.20                 Enzyme                                 

Name
leukotriene-C4 synthase;
leukotriene C4 synthetase;
LTC4 synthase;
LTC4 synthetase;
leukotriene A4:glutathione S-leukotrienyltransferase;
(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening);
(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
Reaction(IUBMB)
leukotriene C4 = leukotriene A4 + glutathione [RN:R03059]
Reaction(KEGG)
Substrate
leukotriene C4 [CPD:C02166]
Product
leukotriene A4 [CPD:C00909];
glutathione [CPD:C00051]
Comment
The reaction proceeds in the direction of addition. Not identical with EC 2.5.1.18, glutathione transferase.
History
EC 4.4.1.20 created 1989 as EC 2.5.1.37, transferred 2004 to EC 4.4.1.20
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00807  leukotriene-C4 synthase
Genes
HSA: 4056(LTC4S)
PTR: 739986(LTC4S)
PPS: 100983593(LTC4S)
GGO: 101148178(LTC4S)
PON: 100456952(LTC4S)
NLE: 101179421(LTC4S)
MCC: 705233(LTC4S)
MCF: 102141868(LTC4S)
CSAB: 103245108(LTC4S)
RRO: 104676203(LTC4S)
RBB: 108523369(LTC4S)
CJC: 100385291(LTC4S)
MMU: 17001(Ltc4s)
RNO: 114097(Ltc4s)
CGE: 103162531
NGI: 103749375(Ltc4s)
HGL: 101722474(Ltc4s)
CCAN: 109686722(Ltc4s)
OCU: 100341898(LTC4S)
CFA: 607316(LTC4S)
AML: 105238479(LTC4S)
ORO: 101378794(LTC4S)
FCA: 101096198(LTC4S)
PTG: 102964525(LTC4S)
AJU: 106970167(LTC4S)
BTA: 511749(LTC4S)
BOM: 102278603(LTC4S)
OAS: 101119304(LTC4S)
SSC: 100520063(LTC4S)
BACU: 103011981(LTC4S)
LVE: 103085740(LTC4S)
OOR: 101285904(LTC4S)
ECB: 100067282(LTC4S)
EPZ: 103560012(LTC4S)
EAI: 106843724(LTC4S)
HAI: 109392760(LTC4S)
RSS: 109437623(LTC4S)
PALE: 102882511(LTC4S)
LAV: 100675058(LTC4S)
TMU: 101361468
MDO: 100032154(LTC4S)
GGA: 770619(LTC4S) 770665(LTC4SL)
APLA: 101803851(LTC4S) 101804397
TGU: 100218541 100219450(LTC4S)
GFR: 102044383 102044843(LTC4S)
FAB: 101806252 101806896(LTC4S)
PHI: 102109119 102111820(LTC4S)
FPG: 101917253 101919677(LTC4S)
FCH: 102054340(LTC4S) 102055824
AMJ: 102568686(LTC4S) 102571710
CMY: 102936169 102936619(LTC4S)
CPIC: 101945657(LTC4S) 101946405
ACS: 103277893(ltc4s)
PVT: 110073491(LTC4S)
PBI: 103060000(LTC4S)
GJA: 107110314(LTC4S)
XLA: 108712616(ltc4s.1.S) 495166(ltc4s.2.L)
XTR: 100127769(ltc4s.2)
NPR: 108785375
DRE: 100535432(ltc4s)
SGH: 107551000(ltc4s) 107578450
IPU: 108268577(ltc4s)
AMEX: 103033591(ltc4s)
TRU: 101079867(ltc4s)
LCO: 104934865
MZE: 101463928(ltc4s)
OLA: 101165938(ltc4s)
XMA: 102217258(ltc4s)
PRET: 103471803
NFU: 107380837
KMR: 108251405
CSEM: 103391074(ltc4s)
LCF: 108873747
SDU: 111235924
HCQ: 109516552
BPEC: 110165507
MALB: 109956757
SASA: 106611597(ltc4s)
OTW: 112256314(ltc4s)
ELS: 105028348(ltc4s)
SFM: 108925352(ltc4s)
LCM: 102356667(LTC4S) 102366002
CMK: 103188230(ltc4s)
 » show all
Taxonomy
Reference
1  [PMID:6324687]
  Authors
Bach MK, Brashler JR, Morton DR Jr.
  Title
Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase.
  Journal
Arch Biochem Biophys 230:455-65 (1984)
DOI:10.1016/0003-9861(84)90426-0
Reference
2  [PMID:2846379]
  Authors
Shimizu T.
  Title
Enzymes functional in the syntheses of leukotrienes and related compounds.
  Journal
Int J Biochem 20:661-6 (1988)
Reference
3  [PMID:12432940]
  Authors
Lam BK, Austen KF.
  Title
Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes.
  Journal
Prostaglandins Other Lipid Mediat 68-69:511-20 (2002)
DOI:10.1016/S0090-6980(02)00052-7
Reference
4  [PMID:12023288]
  Authors
Christmas P, Weber BM, McKee M, Brown D, Soberman RJ.
  Title
Membrane localization and topology of leukotriene C4 synthase.
  Journal
J Biol Chem 277:28902-8 (2002)
DOI:10.1074/jbc.M203074200
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.20
IUBMB Enzyme Nomenclature: 4.4.1.20
ExPASy - ENZYME nomenclature database: 4.4.1.20
BRENDA, the Enzyme Database: 4.4.1.20
CAS: 90698-32-1

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