KEGG   ENZYME: 4.4.1.26Help
Entry
EC 4.4.1.26                 Enzyme                                 

Name
olivetolic acid cyclase;
OAC
Class
Lyases;
Carbon-sulfur lyases;
Carbon-sulfur lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
3,5,7-trioxododecanoyl-CoA CoA-lyase (2,4-dihydroxy-6-pentylbenzoate-forming)
Reaction(IUBMB)
3,5,7-trioxododecanoyl-CoA = CoA + 2,4-dihydroxy-6-pentylbenzoate [RN:R10278]
Reaction(KEGG)
Substrate
3,5,7-trioxododecanoyl-CoA [CPD:C20413]
Product
CoA [CPD:C00010];
2,4-dihydroxy-6-pentylbenzoate [CPD:C20417]
Comment
Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa.
History
EC 4.4.1.26 created 2012
Pathway
ec00999  Biosynthesis of secondary metabolites - unclassified
Orthology
K20508  olivetolic acid cyclase
Reference
1  [PMID:22802619]
  Authors
Gagne SJ, Stout JM, Liu E, Boubakir Z, Clark SM, Page JE
  Title
Identification of olivetolic acid cyclase from Cannabis sativa reveals a unique catalytic route to plant polyketides.
  Journal
Proc Natl Acad Sci U S A 109:12811-6 (2012)
DOI:10.1073/pnas.1200330109
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.4.1.26
IUBMB Enzyme Nomenclature: 4.4.1.26
ExPASy - ENZYME nomenclature database: 4.4.1.26
BRENDA, the Enzyme Database: 4.4.1.26

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