KEGG   ENZYME: 4.5.1.3Help
Entry
EC 4.5.1.3                  Enzyme                                 

Name
dichloromethane dehalogenase;
dichloromethane chloride-lyase (chloride-hydrolysing)
Class
Lyases;
Carbon-halide lyases;
Carbon-halide lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)
Reaction(IUBMB)
dichloromethane + H2O = formaldehyde + 2 chloride [RN:R00603]
Reaction(KEGG)
Substrate
dichloromethane [CPD:C02271];
H2O [CPD:C00001]
Product
formaldehyde [CPD:C00067];
chloride [CPD:C00698]
Comment
Requires glutathione.
History
EC 4.5.1.3 created 1989
Pathway
ec00625  Chloroalkane and chloroalkene degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K17070  dichloromethane dehalogenase
Genes
MDI: METDI2656(dcmA)
HDN: Hden_0711
Taxonomy
Reference
1  [PMID:3988708]
  Authors
Kohler-Staub D, Leisinger T.
  Title
Dichloromethane dehalogenase of Hyphomicrobium sp. strain DM2.
  Journal
J Bacteriol 162:676-81 (1985)
Other DBs
ExplorEnz - The Enzyme Database: 4.5.1.3
IUBMB Enzyme Nomenclature: 4.5.1.3
ExPASy - ENZYME nomenclature database: 4.5.1.3
UM-BBD (Biocatalysis/Biodegradation Database): 4.5.1.3
BRENDA, the Enzyme Database: 4.5.1.3
CAS: 97002-70-5

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