KEGG   ENZYME: 4.6.1.15Help
Entry
EC 4.6.1.15                 Enzyme                                 

Name
FAD-AMP lyase (cyclizing);
FMN cyclase;
FAD AMP-lyase (cyclic-FMN-forming)
Class
Lyases;
Phosphorus-oxygen lyases;
Phosphorus-oxygen lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
FAD AMP-lyase (riboflavin-cyclic-4',5'-phosphate-forming)
Reaction(IUBMB)
FAD = AMP + riboflavin cyclic-4',5'-phosphate [RN:R07636]
Reaction(KEGG)
Substrate
FAD [CPD:C00016]
Product
AMP [CPD:C00020];
riboflavin cyclic-4',5'-phosphate [CPD:C16071]
Comment
Requires Mn2+ or Co2+. While FAD was the best substrate tested [2], the enzyme also splits ribonucleoside diphosphate-X compounds in which X is an acyclic or cyclic monosaccharide or derivative bearing an X-OH group that is able to attack internally the proximal phosphorus with the geometry necessary to form a P=X product; either a five-atom monocyclic phosphodiester or a cis-bicyclic phosphodiester-pyranose fusion. The reaction is strongly inhibited by ADP or ATP but is unaffected by the presence of the product, cFMN.
History
EC 4.6.1.15 created 2002
Orthology
K00863  triose/dihydroxyacetone kinase / FAD-AMP lyase (cyclizing)
Genes
HSA: 26007(TKFC)
PTR: 466626(TKFC)
PPS: 100974411(TKFC)
GGO: 101128538(TKFC)
PON: 100439500(TKFC)
NLE: 100591351(TKFC)
MCC: 694117(TKFC)
MCF: 102140150(TKFC)
CSAB: 103234474(TKFC)
RRO: 104679394(TKFC)
RBB: 108533618(TKFC)
CJC: 100415031(TKFC)
SBQ: 101047818(DAK)
MMU: 225913(Tkfc)
RNO: 361730(Tkfc)
CGE: 100765605(Tkfc)
NGI: 103724936(Tkfc)
HGL: 101710604(Tkfc)
CCAN: 109687386(Tkfc)
OCU: 100344187(TKFC)
TUP: 102491754(TKFC)
CFA: 483800(TKFC)
AML: 100471465(TKFC)
UMR: 103678225(TKFC)
ORO: 101369948(TKFC)
FCA: 101081330(TKFC)
PTG: 102958008(TKFC)
AJU: 106977860(TKFC)
BTA: 512373(TKFC)
BOM: 102277749(TKFC)
BIU: 109554276(TKFC)
PHD: 102341041(TKFC)
CHX: 102173368(TKFC)
OAS: 101106378(TKFC)
SSC: 100520121(TKFC)
CFR: 102524457(TKFC)
CDK: 105094884(TKFC)
BACU: 103012192(TKFC)
LVE: 103087760(TKFC)
OOR: 101271651(TKFC)
ECB: 100059639(TKFC)
EPZ: 103563966(TKFC)
EAI: 106847572(TKFC)
MYB: 102255909(TKFC)
MYD: 102760581(TKFC)
HAI: 109389969(TKFC)
RSS: 109459521(TKFC)
PALE: 102897271(TKFC)
LAV: 100655773(TKFC)
TMU: 101349905
MDO: 100029804(TKFC)
SHR: 100932911(TKFC)
OAA: 100076247(TKFC)
GGA: 426629(TKFC)
MGP: 100538423(TKFC)
CJO: 107314198(TKFC)
TGU: 100225815(TKFC)
GFR: 102037738(TKFC)
FAB: 101813291(TKFC)
PHI: 102109793(TKFC)
PMAJ: 107206333(TKFC)
CCAE: 111930602(TKFC)
CCW: 104684142(TKFC)
FPG: 101916728(TKFC)
FCH: 102056266(TKFC)
CLV: 102083757(TKFC)
AAM: 106494896(TKFC)
ASN: 102380822(TKFC)
AMJ: 102566051(TKFC)
PSS: 102458392(TKFC)
CMY: 102935253(TKFC)
CPIC: 101934870(TKFC)
ACS: 100553788(tkfc)
PVT: 110078319(TKFC)
PBI: 103056665(TKFC)
GJA: 107121403(TKFC)
XLA: 108715194(tkfc.S)
XTR: 779584(tkfc)
NPR: 108794171(TKFC)
DRE: 793926(tkfc)
SRX: 107731922
SANH: 107675501(tkfc)
SGH: 107595319(tkfc)
CCAR: 109093694(tkfc)
IPU: 108267727(tkfc)
AMEX: 103037716(tkfc)
MZE: 101472672(tkfc)
OLA: 101174800(tkfc)
XMA: 102222466(tkfc)
PRET: 103480605(tkfc)
NFU: 107397385(tkfc)
KMR: 108249671(tkfc)
CSEM: 103386061(tkfc)
LCF: 108891958(tkfc)
SDU: 111233365(tkfc)
HCQ: 109506957(tkfc)
BPEC: 110171982(tkfc)
MALB: 109974193(tkfc)
SASA: 106608461(tkfc)
OTW: 112239034(tkfc)
ELS: 105007456(tkfc)
SFM: 108924172(tkfc)
LCM: 102352724(TKFC)
CMK: 103191379(tkfc)
CIN: 100182010
SPU: 575781
SKO: 100371401
AAG: 5577462
AME: 413697
SOC: 105199421
CFO: 105247830
LHU: 105672792
NVI: 100123547
MDL: 103575246
TCA: 658745
DPA: 109538300
NVL: 108556416
BMOR: 101738177
PMAC: 106719425
PRAP: 110996077
HAW: 110382656
ZNE: 110841502
TUT: 107364048
CEL: CELE_W02H5.8(W02H5.8)
CBR: CBG06637
BMY: Bm1_09205
TSP: Tsp_10569
MYI: 110446463
OBI: 106884066
EPA: 110235611
HMG: 101240707
THJ: 104809824
CPAP: 110823189
CIT: 102609834
TCC: 18604460
GMX: 100801639 547519(DHBK)
VRA: 106773212
VAR: 108345892
CAM: 101489047
LJA: Lj2g3v0635680.1(Lj2g3v0635680.1) Lj2g3v0635680.2(Lj2g3v0635680.2) Lj2g3v0636050.1(Lj2g3v0636050.1)
FVE: 101297349
PPER: 18776332
PMUM: 103338905
PAVI: 110746575
ZJU: 107419489
CSV: 101209672
CMO: 103492190
MCHA: 111008837
CMAX: 111495186
CMOS: 111431479
CPEP: 111782820
RCU: 8287868
JCU: 105628863
VVI: 100245056
SLY: 544126(dhbK)
SPEN: 107023685
SOT: 102592901
CANN: 107875831
NSY: 104241834
NTO: 104115304
INI: 109153137
SIND: 105165796
HAN: 110930531
LSV: 111915150
CCAV: 112525755
DCR: 108215128
BVG: 104901368
SOE: 110789017
OSA: 4333926
DOSA: Os03t0719300-01(Os03g0719300)
OBR: 102716582
BDI: 100842608
ATS: 109753929(LOC109753929)
MUS: 103987583
DCT: 110110175
PEQ: 110026307
AOF: 109833528
ATR: 18439224
CRE: CHLREDRAFT_205971(DAK1)
MNG: MNEG_2036
SCE: YFL053W(DAK2) YML070W(DAK1)
ERC: Ecym_1148
KMX: KLMA_50161(DAK1)
NCS: NCAS_0A06130(NCAS0A06130)
NDI: NDAI_0D03110(NDAI0D03110)
TPF: TPHA_0B01670(TPHA0B01670)
TBL: TBLA_0B06340(TBLA0B06340)
TDL: TDEL_0C00180(TDEL0C00180) TDEL_0D00840(TDEL0D00840)
KAF: KAFR_0I00330(KAFR0I00330)
PIC: PICST_31117(DAK1.1) PICST_53027(DAK1.2) PICST_57462(DAK2)
CAL: CAALFM_C109190CA(DAK2)
CAUR: QG37_06298
SLB: AWJ20_2310(DAK1) AWJ20_3444(DAK2) AWJ20_4503(DAK1)
NCR: NCU03779(dak-1) NCU04400
NTE: NEUTE1DRAFT121216(NEUTE1DRAFT_121216) NEUTE1DRAFT58250(NEUTE1DRAFT_58250)
ANI: AN0034.2
ANG: ANI_1_890124(An14g06500)
ABE: ARB_03384
TVE: TRV_08068
SPO: SPAC22A12.11(dak1) SPAC977.16c(dak2)
ABP: AGABI1DRAFT90110(AGABI1DRAFT_90110)
ABV: AGABI2DRAFT222826(AGABI2DRAFT_222826) AGABI2DRAFT229242(AGABI2DRAFT_229242)
MGL: MGL_0770
SMIN: v1.2.023563.t1(symbB.v1.2.023563.t1)
SPAR: SPRG_01160
EFE: EFER_0430
ENC: ECL_04599
ECLO: ENC_34560
EEC: EcWSU1_04023(dhaK)
ECLX: LI66_20150
ECLY: LI62_22130
ECLZ: LI64_19250
ECAN: CWI88_02350(dhaK)
ESA: ESA_03459
CSK: ES15_3420
CTU: CTU_05070(dhaK)
KPN: KPN_03498(dhaK)
KPU: KP1_4795
KPP: A79E_0619
KPT: VK055_3970(dhaK2)
KPE: KPK_0615
KPR: KPR_4702(dhaK)
KPJ: N559_0676
KPX: PMK1_01016(dhaK_2)
KPNU: LI86_03265
KPNK: BN49_0609(dhaK1)
KVA: Kvar_0602
KOE: A225_5089
EAE: EAE_03865
EAR: CCG33219
KQV: B8P98_03305(dhaK)
CKO: CKO_04479
CRO: ROD_03771
CBRA: A6J81_20520(dhaK)
CWE: CO701_01105(dhaK)
CYO: CD187_03180(dhaK)
CAMA: F384_24715
CIF: AL515_20275(dhaK)
CIR: C2U53_02020(dhaK)
CIE: AN232_07845(dhaK)
EBT: EBL_c30290(dhaK1)
RAO: DSD31_03350(dhaK)
RAA: Q7S_19595
ECA: ECA0866
PATR: EV46_03980
PATO: GZ59_08020
SOD: Sant_0988
EGE: EM595_3155(dhaK)
PVA: Pvag_pPag30187(dhbK)
TPTY: NCTC11468_01630(dhaK)
LGU: LG3211_1856(dhaK)
GAI: IMCC3135_18835(dhaK)
CSA: Csal_2326
HEL: HELO_2943(dhaK)
HAM: HALO1390
BMA: BMA1001(dak)
BMAL: DM55_2874(dak)
BMAE: DM78_1552(dak)
BMAQ: DM76_2858(dak)
BMAI: DM57_196
BMAF: DM51_754
BPS: BPSL1613
BPM: BURPS1710b_2248(dak)
BPSE: BDL_159(dak)
BPSM: BBQ_1492(dak)
BPSU: BBN_1618(dak)
BPSD: BBX_2095(dak)
BPK: BBK_3113(dak)
BPSH: DR55_2728(dak)
BPSA: BBU_309(dak)
BPSO: X996_2322(dak)
BUT: X994_748
BTE: BTH_I2329
BTQ: BTQ_1589(dak)
BTJ: BTJ_767(dak)
BTZ: BTL_2004(dak)
BTD: BTI_1824(dak)
BTV: BTHA_2160(dak)
BTHE: BTN_2757(dak)
BTHM: BTRA_2288(dak)
BTHA: DR62_2907
BTHL: BG87_2230
BVE: AK36_6051
BCN: Bcen_5792
BCJ: BCAS0051
BCEN: DM39_6662(dak)
BCEO: I35_7048
BAM: Bamb_6032
BMU: Bmul_6137
BMJ: BMULJ_05394(dak1)
BMK: DM80_6591
BMUL: NP80_5344
BCED: DM42_6421(dhaL) DM42_6525
BCON: NL30_33765
BUB: BW23_3201
BTEI: WS51_29650
BSEM: WJ12_19000
BPSL: WS57_18455
BMEC: WJ16_19785
BSTG: WT74_09370
BGU: KS03_1640(dhaL)
BGO: BM43_2153(dhaL)
BUK: MYA_5072
BUL: BW21_1933(dAK)
BGP: BGL_1c07050(dhaK)
BXE: Bxe_B2559
BXB: DR64_4885(dhaK)
BFN: OI25_5137(dhaL)
ODI: ODI_R1267
POL: Bpro_1459
VEI: Veis_2047
DAC: Daci_4585
NET: Neut_1377
MXA: MXAN_0618
CCX: COCOR_04370(dak1)
MLO: mll5296
SME: SM_b20767(dak)
SMEL: SM2011_b20767(dak)
SMD: Smed_4228
SFD: USDA257_c15770(dhaK1) USDA257_c18780(dhaK2) USDA257_c27550(dhaK3)
SIX: BSY16_2398(dhaL)
SAME: SAMCFNEI73_pC0527(dhaK)
ATU: Atu3543(dhbK)
AGC: BSY240_25
RET: RHE_CH02988(dak)
REC: RHECIAT_CH0002635(dhaK)
RLE: RL2900(dhaK1)
RLG: Rleg_2432
RHL: LPU83_pLPU83c0203(dhaK3)
SHZ: shn_26435
OAN: Oant_3102
AZC: AZC_4706
SNO: Snov_4106
MEX: Mext_1031
MEA: Mex_1p0796(dhaK)
MDI: METDI1510(dhaK)
MCH: Mchl_1158
MPO: Mpop_0963
MET: M446_3559
MOR: MOC_3256
MAQU: Maq22A_c00710(dak1)
MMED: Mame_03294(dhaK_3)
HDI: HDIA_3320(dhaK)
OAT: OAN307_c43560(dhaK)
RMM: ROSMUCSMR3_02836(dhaK)
GOX: GOX2222
GOH: B932_2311
GXY: GLX_05270
GXL: H845_1637
KEU: S101446_00902(dak1)
BHA: BH3393
BANV: DJ46_5425(dhaK2) DJ46_5427(dhaK)
BCZ: BCE33L0868(dhaL) BCE33L0870(dhaL) BCE33L0873(dhaL)
BCQ: BCQ_1042 BCQ_1044(dhaL)
BCX: BCA_1005(dhaK) BCA_1007
BAL: BACI_c10010(dhaL1) BACI_c10030(dhaL2)
BTK: BT9727_0887(dhaL) BT9727_0889(dhaL)
BTG: BTB_c10260(dhaK1) BTB_c10280(dhaK2)
BTW: BF38_2210(dhaK2) BF38_2212(dhaK)
BWW: bwei_4034(dhaK2) bwei_4036(dhaK3)
BMYO: BG05_4930(dhaK) BG05_4932(dhaK2)
BMYC: DJ92_3629(dhaK2) DJ92_3631(dhaK)
BMQ: BMQ_1806(dhaK)
BEO: BEH_03010
BBEV: BBEV_0425(dhaQ)
BSE: Bsel_0941
PPY: PPE_03501
PPO: PPM_3759(dhaL)
PPOL: X809_34730
PPQ: PPSQR21_037460(dAK1)
PRI: PRIO_2676
LLK: LLKF_0243(dhaQ)
LLT: CVCAS_0227(dhaK1)
LLS: lilo_0203(dhaK)
LLD: P620_01545(dhaK2)
LLX: NCDO2118_0241(dhaQ)
LLC: LACR_0250
LLM: llmg_0255(dhaK)
LLR: llh_1460
LLI: uc509_0248(dhaK)
LLW: kw2_0237
LLJ: LG36_0229(dhaQ)
LPK: LACPI_1474(dhaQ)
SPYA: A20_0476
SPF: SpyM51439
SPYH: L897_02350
SPV: SPH_1294(dhaK2)
SGC: A964_1551
SAGM: BSA_17050
SAGI: MSA_17710
SAGR: SAIL_16980
SAGE: EN72_08910
SAGG: EN73_08065
SAGN: W903_1639
SSI: SSU1747
SUP: YYK_08405
SSUY: YB51_8865
SSUT: TL13_1761(dhaK)
SSUI: T15_2028
SEQ: SZO_05640(dhaQ)
SUB: SUB0541
SDS: SDEG_0554
SDA: GGS_0529
SDC: SDSE_0583(dhaQ)
SDQ: SDSE167_0606(dhaQ)
SGT: SGGB_1050(dhaQ)
SMB: smi_1049
STK: STP_0345
STB: SGPB_0917(dhaQ)
SIU: SII_0062
SANG: SAIN_0060
SANC: SANR_0060
SANS: DK43_09825
SCG: SCI_0063
SCON: SCRE_0063
SCOS: SCR2_0063
SIK: K710_1437
LPL: lp_0166(dak1A)
LPJ: JDM1_0155(dak1A)
LPT: zj316_0370(dak1A)
LPS: LPST_C0134(dak1A)
LPZ: Lp16_0150
LSL: LSL_1634(dAK)
LSI: HN6_01372(dAK)
LSJ: LSJ_1692(dAK)
LRM: LRC_17760(dhaQ)
CML: BN424_3626(dhaK2)
CPE: CPE0100
CPF: CPF_0095
CPR: CPR_1160
CBO: CBO0975(dhaK)
CBA: CLB_1015(dhaKL)
CBH: CLC_1029(dhaKL)
CBY: CLM_1131(dhaKL)
CBL: CLK_0423(dhaKL)
CBK: CLL_A0538(dhaKL)
CBB: CLD_3590(dhaKL)
CBI: CLJ_B1020(dhaKL)
CBF: CLI_1061(dhaKL)
CBM: CBF_1031(dhaKL)
CPAT: CLPA_c12160(dhaK)
CPAE: CPAST_c12160(dhaK)
CLD: CLSPO_c09760(dhaK)
MHG: MHY_24620
MMC: Mmcs_5133
MKM: Mkms_5222
MJL: Mjls_5514
MAB: MAB_0194
MABB: MASS_0192
CVA: CVAR_2021(dhaL)
CGV: CGLAU_08605(dhaK)
RER: RER_56200(dak)
REY: O5Y_26840
ROP: ROP_15290(dak)
RHB: NY08_4103
RFA: A3L23_02262(dhaK)
RHS: A3Q41_01119(dhaK)
RHU: A3Q40_00763(dhaK)
GBR: Gbro_4101
TPR: Tpau_0779
SCO: SCO0580(SCF55.04c)
SFA: Sfla_3629
SBH: SBI_04330(dak2)
STRP: F750_3088
SALL: SAZ_29950
STRD: NI25_01455
SMAL: SMALA_4772
CMI: CMM_0788(dakA)
CMS: CMS2383
CMC: CMN_00743(dakA)
MTS: MTES_2016
ARM: ART_3795
ARTH: C3B78_10715(dhaL)
AAU: AAur_1102
DCO: SAMEA4475696_0474(dhaK)
PAC: PPA0622
MPH: MLP_03260
NCA: Noca_3316
TFU: Tfu_1716
SEN: SACE_4765(dak)
PSEA: WY02_03005
AMI: Amir_2647
ACTI: UA75_20470
ACAD: UA74_19970
AFS: AFR_08505
CAI: Caci_1105
SNA: Snas_4072
AHE: Arch_1123
OLS: Olsu_0402
TTR: Tter_2484
SACI: Sinac_3843
ABAS: ACPOL_1704
CPI: Cpin_4584
ZPR: ZPR_4331
 » show all
Taxonomy
Reference
1  [PMID:9480905]
  Authors
Fraiz FJ, Pinto RM, Costas MJ, Aavalos M, Canales J, Cabezas A, Cameselle JC.
  Title
Enzymic formation of riboflavin 4',5'-cyclic phosphate from FAD: evidence for a specific low-Km FMN cyclase in rat liver1.
  Journal
Biochem J 330 ( Pt 2):881-8 (1998)
Reference
2  [PMID:11695920]
  Authors
Cabezas A, Pinto RM, Fraiz F, Canales J, Gonzalez-Santiago S, Cameselle JC.
  Title
Purification, characterization, and substrate and inhibitor structure-activity studies of rat liver FAD-AMP lyase (cyclizing): preference for FAD and specificity for splitting ribonucleoside diphosphate-X into ribonucleotide and a five-atom cyclic phosphodiester of X, either a monocyclic compound or a cis-bicyclic phosphodiester-pyranose fusion.
  Journal
Biochemistry 40:13710-22 (2001)
DOI:10.1021/bi0157159
  Sequence
[rno:361730]
Other DBs
ExplorEnz - The Enzyme Database: 4.6.1.15
IUBMB Enzyme Nomenclature: 4.6.1.15
ExPASy - ENZYME nomenclature database: 4.6.1.15
BRENDA, the Enzyme Database: 4.6.1.15
CAS: 208349-48-8

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