KEGG   ENZYME: 4.99.1.8Help
Entry
EC 4.99.1.8                 Enzyme                                 

Name
heme ligase;
heme detoxification protein;
HDP;
hemozoin synthase
Class
Lyases;
Other lyases;
Sole sub-subclass for lyases that do not belong in the other subclasses
BRITE hierarchy
Sysname
Fe3+:ferriprotoporphyrin IX ligase (beta-hematin-forming)
Reaction(IUBMB)
2 ferriprotoporphyrin IX = beta-hematin
Substrate
ferriprotoporphyrin IX
Product
beta-hematin
Comment
This heme detoxifying enzyme is found in Plasmodium parasites and converts toxic heme to crystalline hemozoin. These organisms lack the mammalian heme oxygenase for elimination of heme.
History
EC 4.99.1.8 created 2009
Orthology
K17949  heme ligase
Genes
PFA: PF3D7_1446800
PFD: PFDG_04534
PFH: PFHG_04214
PYO: PY17X_1314400
PCB: PCHAS_131390(PC000111.02.0)
PBE: PBANKA_131060
PKN: PKH_125960
PVX: PVX_118155
PCY: PCYB_126830
TAN: TA11080
TPV: TP04_0891
BBO: BBOV_III009730(17.m07844)
 » show all
Taxonomy
Reference
1  [PMID:18437218]
  Authors
Jani D, Nagarkatti R, Beatty W, Angel R, Slebodnick C, Andersen J, Kumar S, Rathore D
  Title
HDP-a novel heme detoxification protein from the malaria parasite.
  Journal
PLoS Pathog 4:e1000053 (2008)
DOI:10.1371/journal.ppat.1000053
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 4.99.1.8
IUBMB Enzyme Nomenclature: 4.99.1.8
ExPASy - ENZYME nomenclature database: 4.99.1.8
BRENDA, the Enzyme Database: 4.99.1.8

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