KEGG   ENZYME: 5.1.1.15Help
Entry
EC 5.1.1.15                 Enzyme                                 

Name
2-aminohexano-6-lactam racemase;
alpha-amino-epsilon-caprolactam racemase
Class
Isomerases;
Racemases and epimerases;
Acting on amino acids and derivatives
BRITE hierarchy
Sysname
2-aminohexano-6-lactam racemase
Reaction(IUBMB)
(S)-2-aminohexano-6-lactam = (R)-2-aminohexano-6-lactam [RN:R04736]
Reaction(KEGG)
Substrate
(S)-2-aminohexano-6-lactam [CPD:C02837]
Product
(R)-2-aminohexano-6-lactam [CPD:C05328]
Comment
Contains pyridoxal 5'-phosphate. Also racemises 2-aminopentano-5-lactam (alpha-amino-delta-valerolactam) and 2-amino-4-thiahexano-6-lactam (where S replaces CH2 of C-4). It does not catalyse the racemisation of alpha-amino acids but has some transaminase activity with them.
History
EC 5.1.1.15 created 1999
Reference
1
  Authors
Ahmed, S.A., Esaki, N., Tanaka, H., Soda, K.
  Title
L-alpha-Amino-beta-thio-epsilon-caprolactam, a new sulfur-containing substrate for alpha-amino-epsilon-caprolactam racemase.
  Journal
FEBS Lett 174:76-79 (1984)
Reference
2  [PMID:3955003]
  Authors
Ahmed SA, Esaki N, Tanaka H, Soda K.
  Title
Mechanism of alpha-amino-epsilon-caprolactam racemase reaction.
  Journal
Biochemistry 25:385-8 (1986)
Reference
3  [PMID:19146406]
  Authors
Okazaki S, Suzuki A, Mizushima T, Kawano T, Komeda H, Asano Y, Yamane T
  Title
The novel structure of a pyridoxal 5'-phosphate-dependent fold-type I racemase, alpha-amino-epsilon-caprolactam racemase from Achromobacter obae.
  Journal
Biochemistry 48:941-50 (2009)
DOI:10.1021/bi801574p
Other DBs
ExplorEnz - The Enzyme Database: 5.1.1.15
IUBMB Enzyme Nomenclature: 5.1.1.15
ExPASy - ENZYME nomenclature database: 5.1.1.15
BRENDA, the Enzyme Database: 5.1.1.15
CAS: 52652-64-9

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