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Entry
EC 5.2.1.12                 Enzyme                                 

Name
zeta-carotene isomerase;
Z-ISO;
15-cis-zeta-carotene isomerase
Class
Isomerases;
cis-trans-Isomerases;
cis-trans Isomerases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
9,15,9'-tricis-zeta-carotene cis-trans-isomerase
Reaction(IUBMB)
9,15,9'-tricis-zeta-carotene = 9,9'-dicis-zeta-carotene [RN:R09655]
Reaction(KEGG)
Substrate
9,15,9'-tricis-zeta-carotene [CPD:C19764]
Product
9,9'-dicis-zeta-carotene [CPD:C15857]
Comment
The enzyme catalyses the cis-trans isomerization of the 15-15' carbon-carbon double bond in 9,15,9'-tricis-zeta-carotene, which is required for biosynthesis of all plant carotenoids. Requires heme b.
History
EC 5.2.1.12 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K15744  zeta-carotene isomerase
Genes
ATH: AT1G10830(Z-ISO)
ALY: ARALYDRAFT_471219
CRB: 17899102
CSAT: 104739709 104755305 104769441
EUS: EUTSA_v10000634mg EUTSA_v10007996mg
BRP: 103871859
BNA: 106350180 106357937 106368192
BOE: 106343736
THJ: 104823658
CPAP: 110821616
CIT: 102630760
TCC: 18592559
GRA: 105797062
DZI: 111298953
EGR: 104438291
VRA: 106778251
VAR: 108318983
CCAJ: 109795797
LJA: Lj4g3v2573880.1(Lj4g3v2573880.1)
ADU: 107482417
AIP: 107638274
FVE: 101302159
PPER: 18790341
PMUM: 103342570
PAVI: 110745375
MDM: 103400646
PXB: 103960405
CSV: 101211624
CMO: 103494534
MCHA: 111014723
CMAX: 111470740
CMOS: 111439180
CPEP: 111800986
RCU: 8262245
JCU: 105636165
HBR: 110632161
POP: 7466321
JRE: 108996307
VVI: 100258367
SLY: 101253762(Z-ISO)
SPEN: 107007592
SOT: 102600257
CANN: 107850257
NTA: 107798230
NSY: 104238890
NTO: 104121634
INI: 109167937
SIND: 105158676
HAN: 110885023
LSV: 111887957
DCR: 108196139
BVG: 104889684
SOE: 110800142
NNU: 104589367
OSA: 4352042
DOSA: Os12t0405200-01(Os12g0405200)
OBR: 102721697
BDI: 100842276
ATS: 109740170(LOC109740170)
SBI: 110429871
ZMA: 100194203
SITA: 101783502
PDA: 103722002
EGU: 105038852
DCT: 110105626
AOF: 109823824
ATR: 18438214
APRO: F751_1881
FCY: FRACYDRAFT_291550(Z-ISO)
 » show all
Taxonomy
Reference
1  [PMID:20335404]
  Authors
Chen Y, Li F, Wurtzel ET
  Title
Isolation and characterization of the Z-ISO gene encoding a missing component of  carotenoid biosynthesis in plants.
  Journal
Plant Physiol 153:66-79 (2010)
DOI:10.1104/pp.110.153916
  Sequence
[ath:AT1G10830] [zma:100194203]
Reference
2  [PMID:17434985]
  Authors
Li F, Murillo C, Wurtzel ET
  Title
Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization.
  Journal
Plant Physiol 144:1181-9 (2007)
DOI:10.1104/pp.107.098996
  Sequence
[zma:100194203]
Reference
3  [PMID:26075523]
  Authors
Beltran J, Kloss B, Hosler JP, Geng J, Liu A, Modi A, Dawson JH, Sono M, Shumskaya M, Ampomah-Dwamena C, Love JD, Wurtzel ET
  Title
Control of carotenoid biosynthesis through a heme-based cis-trans isomerase.
  Journal
Nat Chem Biol 11:598-605 (2015)
DOI:10.1038/nchembio.1840
Other DBs
ExplorEnz - The Enzyme Database: 5.2.1.12
IUBMB Enzyme Nomenclature: 5.2.1.12
ExPASy - ENZYME nomenclature database: 5.2.1.12
BRENDA, the Enzyme Database: 5.2.1.12

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