KEGG   ENZYME: 5.3.1.21Help
Entry
EC 5.3.1.21                 Enzyme                                 

Name
corticosteroid side-chain-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
BRITE hierarchy
Sysname
11-deoxycorticosterone aldose-ketose-isomerase
Reaction(IUBMB)
11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al [RN:R04165]
Reaction(KEGG)
Substrate
11-deoxycorticosterone [CPD:C03205]
Product
20-hydroxy-3-oxopregn-4-en-21-al [CPD:C04108]
Comment
An epimerization at C-20 and C-21 is probably catalysed by the same enzyme.
History
EC 5.3.1.21 created 1983
Reference
1  [PMID:901753]
  Authors
Martin KO, Oh SW, Lee HJ, Monder C.
  Title
Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme.
  Journal
Biochemistry 16:3803-9 (1977)
Reference
2  [PMID:7391077]
  Authors
Monder C, Martin KO, Bogumil J.
  Title
Presence of epimerase activity in hamster liver corticosteroid side chain isomerase.
  Journal
J Biol Chem 255:7192-8 (1980)
Other DBs
ExplorEnz - The Enzyme Database: 5.3.1.21
IUBMB Enzyme Nomenclature: 5.3.1.21
ExPASy - ENZYME nomenclature database: 5.3.1.21
BRENDA, the Enzyme Database: 5.3.1.21
CAS: 75139-73-0

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