KEGG   ENZYME: 5.3.1.27Help
Entry
EC 5.3.1.27                 Enzyme                                 

Name
6-phospho-3-hexuloisomerase;
3-hexulose-6-phosphate isomerase;
phospho-3-hexuloisomerase;
PHI;
6-phospho-3-hexulose isomerase;
YckF
Class
Isomerases;
Intramolecular oxidoreductases;
Interconverting aldoses and ketoses, and related compounds
BRITE hierarchy
Sysname
D-arabino-hex-3-ulose-6-phosphate isomerase
Reaction(IUBMB)
D-arabino-hex-3-ulose 6-phosphate = D-fructose 6-phosphate [RN:R05339]
Reaction(KEGG)
Substrate
D-arabino-hex-3-ulose 6-phosphate [CPD:C06019]
Product
D-fructose 6-phosphate [CPD:C00085]
Comment
This enzyme, along with EC 4.1.2.43, 3-hexulose-6-phosphate synthase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of EC 4.1.2.43 (3-hexulose-6-phosphate synthase) and this enzyme [4].
History
EC 5.3.1.27 created 2008
Pathway
ec00030  Pentose phosphate pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08094  6-phospho-3-hexuloisomerase
K13831  3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
Genes
ECG: E2348C_4131
ECC: c4757
ECP: ECP_4027
ECI: UTI89_C4398
ECV: APECO1_2643
ECQ: ECED1_4515
EUM: ECUMN_2964
ECZ: ECS88_4262
ELN: NRG857_10055 NRG857_19035
ESE: ECSF_3670
EIH: ECOK1_4282(hxlB)
ELC: i14_4352
ELD: i02_4352
ECOI: ECOPMV1_04171(hxlB)
ECOJ: P423_21200
ECOS: EC958_4293
STM: STM2756
SEY: SL1344_2740(hxlB)
SEB: STM474_2891(hxlB)
SEF: UMN798_2990(hxlB)
SENI: CY43_14400
SENS: Q786_21245
EEC: EcWSU1_A067(hxlB) EcWSU1_A079(hxlB)
ECLZ: LI64_16170
ECAN: CWI88_05390(hxlB)
KPN: KPN_02958
PSTS: E05_34000
MAH: MEALZ_1912(hpsi2) MEALZ_3952(hpi1)
MEJ: Q7A_2502(hxlB)
MEC: Q7C_1683
MFA: Mfla_1653
MMB: Mmol_1337
MEH: M301_1546
MEP: MPQ_1560
MBAC: BN1209_0772(rmpB)
MBAT: BN1208_0844(hpi)
MLO: mlr8483
DSH: Dshi_0552
RRU: Rru_A1367
RRF: F11_07060
BSU: BSU03450(hxlB)
BSR: I33_0396(hxlB)
BSL: A7A1_1852
BSH: BSU6051_03450(hxlB)
BSUT: BSUB_00395(hxlB)
BSUL: BSUA_00395(hxlB)
BSUS: Q433_02065
BSS: BSUW23_01785(hxlB)
BST: GYO_0558(hxlB)
BSO: BSNT_06680(hxlB)
BSQ: B657_03450(hxlB)
BSX: C663_0336(hxlB1) C663_0337(hxlB2)
BLI: BL02046(hxlB)
BLD: BLi02804(hxlB)
BLH: BaLi_c28990(hxlB)
BAY: RBAM_003620(hxlB)
BAQ: BACAU_0302(hxlB)
BYA: BANAU_0304(hxlB)
BAMP: B938_01570
BAML: BAM5036_0321(hxlB)
BAMA: RBAU_0336(hxlB)
BAMN: BASU_0320(hxlB)
BAMB: BAPNAU_0306(hxlB)
BAMT: AJ82_01975
BAMY: V529_03240(hxlB)
BMP: NG74_00344(hxlB)
BAO: BAMF_0309(hxlB)
BAZ: BAMTA208_01550(hxlB)
BQL: LL3_00317(hxlB)
BXH: BAXH7_00320(hxlB)
BQY: MUS_0324(hxlB)
BAMI: KSO_017860
BAMC: U471_03220
BAMF: U722_01855
BATR: TD68_19405
BCL: ABC3354(hxlB)
BPU: BPUM_2332
BPUM: BW16_12645
BPUS: UP12_11775
BMH: BMWSH_4351(hxlB)
BMEG: BG04_3185(hxlB) BG04_5471(hxlB) BG04_5931(hxlB)
BCOA: BF29_2768(hxlB) BF29_3094
BJS: MY9_0360
BMET: BMMGA3_06840(hxlB)
BACW: QR42_11735
BACP: SB24_07995
BACB: OY17_04475
BACY: QF06_00685
BACL: BS34A_04020(hxlB)
BALM: BsLM_0361
BGY: BGLY_3089(hxlB)
BKW: BkAM31D_07115(hxlB_1) BkAM31D_16320(hxlB_2)
BBEV: BBEV_0242(rmpB) BBEV_2196(hxlB)
BALT: CFN77_12445(hxlB)
OCN: CUC15_15175(hxlB)
GTN: GTNG_1491
GGH: GHH_c21390(hxlB)
GEA: GARCT_00703(hxlB_1) GARCT_02003(hxlB_2)
ANM: GFC28_663(hxlB)
ANL: GFC29_963(hxlB)
VIL: CFK37_17675(hxlB)
VNE: CFK40_05145(hxlB)
VPN: A21D_01729(hxlB)
SAU: SA0529
SAV: SAV0571
SAW: SAHV_0569
SAM: MW0526
SAS: SAS0529
SAR: SAR0575
SAC: SACOL0618
SAE: NWMN_0534
SAD: SAAV_0534
SUE: SAOV_0606
SUC: ECTR2_525(hxlB)
SUQ: HMPREF0772_12617(hxlB)
SUZ: MS7_0561(hxlB)
SUG: SAPIG0646(hxlB)
SAUA: SAAG_00992
SAUS: SA40_0512
SAUU: SA957_0527
SAUG: SA268_0525
SAUF: X998_0613(hxlB)
SAB: SAB0521
SAUB: C248_0646
SAUM: BN843_5650
SAUC: CA347_587(hxlB)
SAUR: SABB_00622(hxlB)
SAUI: AZ30_02890
SAUD: CH52_02900
SAMS: NI36_02845
SEP: SE0342
SER: SERP0217
SEPP: SEB_00263
SEPS: DP17_1648(hxlB)
SHA: SH2419
SCA: SCA_0225
SDT: SPSE_2212(hxlB)
SPAS: STP1_1659
SHU: SHYC_10790(hxlB)
SCAP: AYP1020_2320(hxlB)
SSCH: LH95_10390
SSCZ: RN70_11125
SAGQ: EP23_11370
SSIF: AL483_08725(hxlB)
SPET: CEP67_09870(hxlB)
SSCU: CEP64_01025(hxlB)
SKL: C7J89_12600(hxlB)
SFQ: C7J90_01800(hxlB)
MCL: MCCL_0036
MCAK: MCCS_00630
ESI: Exig_2371
EAN: Eab7_2215
PPY: PPE_04674
PPM: PPSC2_24310(hxlB)
PPO: PPM_4827(hxlB)
PPQ: PPSQR21_049260(gutQ)
PPOY: RE92_12970
PMW: B2K_37325
PSWU: SY83_08110
PDH: B9T62_30295(hxlB)
PLX: CW734_09540(hxlB) CW734_13375(hxlB)
SUB: SUB0286
SGG: SGGBAA2069_c19300(hxlB)
SGT: SGGB_1961(hxlB)
LBR: LVIS_0443
LPAP: LBPC_0349
LCB: LCABL_04200(phi) LCABL_04500(phi)
LCW: BN194_04280(hxlB) BN194_04570(hxlB_2)
LBN: LBUCD034_0078(hxlB)
PCE: PECL_1749
EFM: M7W_1509
ECAS: ECBG_02724
OOE: OEOE_0132
LMM: MI1_09736
CAC: CA_C0397
CAE: SMB_G0405
CAY: CEA_G0407
CBEI: LF65_06880
CBOL: CGC65_09840(hxlB)
TTM: Tthe_1730
PUF: UFO1_0637
PFT: JBW_00829
SAMB: SAM23877_0308(rmpB)
SLE: sle_59920(sle_59920)
CMI: CMM_1124
CMS: CMS1444(rmpB)
CMC: CMN_01093
AGM: DCE93_00165(hxlB)
SALC: C2138_08150(hxlB)
ART: Arth_3709
ARR: ARUE_c04630(rmpB)
ARN: CGK93_01945(hxlB)
ARX: ARZXY2_3982(hxlB)
ARTH: C3B78_00805(hxlB)
AAU: AAur_0493
AAI: AARI_06570(rmpB)
AMQ: AMETH_4517(hpi)
PSEE: FRP1_13265
BDE: BDP_0014
BDN: BBDE_0014
BBRE: B12L_1723
BBRV: B689b_1820
BBRJ: B7017_1986
BBRC: B7019_1960
BBRS: BS27_1782
BBRD: BBBR_1797
BANG: BBAG_0933
CPI: Cpin_5672
FLN: FLA_3347
ZPR: ZPR_1062
MARM: YQ22_17835
CBAL: M667_16190
CBAT: M666_16175
ZGA: ZOBELLIA_3941(hxlB)
MJA: MJ_1247
MMP: MMP1270
MMD: GYY_07185
MAE: Maeo_1163
MMG: MTBMA_c01320(phi1) MTBMA_c06990(phi2)
METE: tca_00229(hxlB_1) tca_01495(hxlB_2)
MST: Msp_0247
MSI: Msm_1391
MRU: mru_0250(phi1)
MMIL: sm9_2187(hxlB)
MEYE: TL18_00870
MOL: YLM1_0018
MFC: BRM9_0164(hxlB1) BRM9_0593(hxlB2)
MKA: MK1663
MEAR: Mpt1_c00380(phi) Mpt1_c14440(faeB)
PHO: PH1938(PH1938)
PAB: PAB1222
PFU: PF0220
PFI: PFC_00160
PYN: PNA2_0868
PYS: Py04_0376
TKO: TK0475
TON: TON_0336
TGA: TGAM_1891(hps)
TSI: TSIB_0428
THE: GQS_03555
THA: TAM4_82
THM: CL1_0365
TLT: OCC_09933
THS: TES1_0756
TNU: BD01_0222
TEU: TEU_06790
PPAC: PAP_05755
MBU: Mbur_1889
MTP: Mthe_0455
MCJ: MCON_0429
MHI: Mhar_1869
MEMA: MMAB1_0908(hps) MMAB1_1456(hpsA) MMAB1_1494
MPD: MCP_0861
MEZ: Mtc_1411
APE: APE_1940.1(hxlB)
ACJ: ACAM_1213(hxlB)
SMR: Smar_0385
IHO: Igni_0788
IIS: EYM_02670
DKA: DKAM_0222
TAG: Tagg_0275
IAG: Igag_1421
HBU: Hbut_1240
STO: STK_01980(hxlB)
SSO: SSO0151(hpS-1)
SOL: Ssol_1130
SSOA: SULA_1166
SSOL: SULB_1167
SSOF: SULC_1165
SAI: Saci_0747
SID: M164_1993
SIH: SiH_1931
SIR: SiRe_1858
SIC: SiL_1840
MSE: Msed_0236
MCN: Mcup_1836
MHK: DFR87_05675(hxlB)
AHO: Ahos_0880
ABRI: DFR85_06600(hxlB)
ASUL: DFR86_07265(hxlB)
PAI: PAE1489
PIS: Pisl_1579
PCL: Pcal_0808
PAS: Pars_0616
PYR: P186_2755
POG: Pogu_1737
TNE: Tneu_0610
CMA: Cmaq_0308
TUZ: TUZN_0737
TTN: TTX_1049(phi)
VDI: Vdis_1032
VMO: VMUT_1868
TPE: Tpen_0479
ASC: ASAC_0446
ACIA: SE86_03105
NCV: NCAV_0256
KCR: Kcr_1608
BARC: AOA65_1432(phi)
 » show all
Taxonomy
Reference
1  [PMID:4219834]
  Authors
Ferenci T, Strom T, Quayle JR
  Title
Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus.
  Journal
Biochem J 144:477-86 (1974)
Reference
2  [PMID:16278835]
  Authors
Yurimoto H, Kato N, Sakai Y
  Title
Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism.
  Journal
Chem Rec 5:367-75 (2005)
DOI:10.1002/tcr.20056
Reference
3  [PMID:16428816]
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
4  [PMID:15901685]
  Authors
Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  Title
The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  Journal
J Bacteriol 187:3636-42 (2005)
DOI:10.1128/JB.187.11.3636-3642.2005
Reference
5  [PMID:11839305]
  Authors
Martinez-Cruz LA, Dreyer MK, Boisvert DC, Yokota H, Martinez-Chantar ML, Kim R, Kim SH
  Title
Crystal structure of MJ1247 protein from M. jannaschii at 2.0 A resolution infers a molecular function of 3-hexulose-6-phosphate isomerase.
  Journal
Structure 10:195-204 (2002)
DOI:10.1016/S0969-2126(02)00701-3
  Sequence
[mja:MJ_1247]
Reference
6  [PMID:11468398]
  Authors
Taylor EJ, Charnock SJ, Colby J, Davies GJ, Black GW
  Title
Cloning, purification and characterization of the 6-phospho-3-hexulose isomerase YckF from Bacillus subtilis.
  Journal
Acta Crystallogr D Biol Crystallogr 57:1138-40 (2001)
Other DBs
ExplorEnz - The Enzyme Database: 5.3.1.27
IUBMB Enzyme Nomenclature: 5.3.1.27
ExPASy - ENZYME nomenclature database: 5.3.1.27
BRENDA, the Enzyme Database: 5.3.1.27

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