KEGG   ENZYME: 5.3.3.7Help
Entry
EC 5.3.3.7                  Enzyme                                 

Name
aconitate Delta-isomerase;
aconitate isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Transposing C=C bonds
BRITE hierarchy
Sysname
aconitate Delta2-Delta3-isomerase
Reaction(IUBMB)
trans-aconitate = cis-aconitate [RN:R02244]
Reaction(KEGG)
Substrate
trans-aconitate [CPD:C02341]
Product
cis-aconitate [CPD:C00417]
Comment
cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. This isomerization could take place either in a direct cis-trans interconversion or by an allylic rearrangement; the enzyme has been shown to catalyse the latter change.
History
EC 5.3.3.7 created 1972
Pathway
ec00660  C5-Branched dibasic acid metabolism
Orthology
K22002  aconitate Delta-isomerase
K22003  aconitate Delta-isomerase
Genes
UMA: UMAG_11778
XAL: XALC_0076
PPW: PputW619_3159
POR: APT59_12225
PSV: PVLB_14130
PPV: NJ69_14215
PPSL: BJP27_03380
PLG: NCTC10937_01292
Taxonomy
Reference
1  [PMID:5114987]
  Authors
Klinman JP, Rose IA.
  Title
Purification and kinetic properties of aconitate isomerase from Pseudomonas putida.
  Journal
Biochemistry 10:2253-9 (1971)
Reference
2  [PMID:5114988]
  Authors
Klinman JP, Rose IA.
  Title
Mechanism of the aconitate isomerase reaction.
  Journal
Biochemistry 10:2259-66 (1971)
Other DBs
ExplorEnz - The Enzyme Database: 5.3.3.7
IUBMB Enzyme Nomenclature: 5.3.3.7
ExPASy - ENZYME nomenclature database: 5.3.3.7
BRENDA, the Enzyme Database: 5.3.3.7
CAS: 37318-48-2

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