| Entry |
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| Name |
thromboxane-A synthase;
thromboxane synthase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase
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| Class |
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
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| Sysname |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase
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| Reaction(IUBMB) |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [RN: R02268]
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| Reaction(KEGG) |
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| Substrate |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD: C00427]
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| Product |
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [CPD: C02198]
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| Comment |
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2.
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| History |
EC 5.3.99.5 created 1984, modified 1990
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| Pathway |
| ec00590 | Arachidonic acid metabolism |
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| Orthology |
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| Genes |
» show all
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| Reference |
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| Authors |
Shen RF, Tai HH. |
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| Title |
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung. |
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| Journal |
J Biol Chem 261:11592-9 (1986) |
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| Reference |
|
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| Authors |
Ullrich V, Haurand M. |
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| Title |
Thromboxane synthase as a cytochrome P450 enzyme. |
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| Journal |
Adv Prostaglandin Thromboxane Leukot Res 11:105-10 (1983) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 5.3.99.5 |
| ExPASy - ENZYME nomenclature database: | 5.3.99.5 |
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