Entry |
|
Name |
thromboxane-A synthase;
thromboxane synthase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase
|
Class |
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
|
Sysname |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase
|
Reaction(IUBMB) |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [RN: R02268]
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Reaction(KEGG) |
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Substrate |
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD: C00427]
|
Product |
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [CPD: C02198]
|
Comment |
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2.
|
History |
EC 5.3.99.5 created 1984, modified 1990
|
Pathway |
ec00590 | Arachidonic acid metabolism |
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Orthology |
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Genes |
» show all
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Reference |
|
Authors |
Shen RF, Tai HH. |
Title |
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung. |
Journal |
J Biol Chem 261:11592-9 (1986) |
Reference |
|
Authors |
Ullrich V, Haurand M. |
Title |
Thromboxane synthase as a cytochrome P450 enzyme. |
Journal |
Adv Prostaglandin Thromboxane Leukot Res 11:105-10 (1983) |
Other DBs |
ExplorEnz - The Enzyme Database: | 5.3.99.5 |
ExPASy - ENZYME nomenclature database: | 5.3.99.5 |
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