KEGG   ENZYME: 5.3.99.5Help
Entry
EC 5.3.99.5                 Enzyme                                 

Name
thromboxane-A synthase;
thromboxane synthase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [RN:R02268]
Reaction(KEGG)
Substrate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [CPD:C02198]
Comment
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2.
History
EC 5.3.99.5 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K01832  thromboxane-A synthase
Genes
HSA: 6916(TBXAS1)
PTR: 463774(TBXAS1)
PPS: 100974860(TBXAS1)
GGO: 101143018(TBXAS1) 109027809
PON: 100173366(TBXAS1)
NLE: 100580072(TBXAS1)
MCC: 711748(TBXAS1)
MCF: 102128548(TBXAS1)
CSAB: 103227005(TBXAS1)
RRO: 104656601(TBXAS1)
RBB: 108534817(TBXAS1)
CJC: 100405880(TBXAS1)
SBQ: 101049596(TBXAS1)
MMU: 21391(Tbxas1)
RNO: 24886(Tbxas1)
CGE: 100772642(Tbxas1)
NGI: 103726097(Tbxas1)
HGL: 101697368(Tbxas1)
CCAN: 109687422(Tbxas1) 109688831
OCU: 100339354(TBXAS1)
TUP: 102482189(TBXAS1)
CFA: 482771(TBXAS1)
AML: 100481563(TBXAS1)
UMR: 103669108(TBXAS1)
ORO: 101374074(TBXAS1)
FCA: 101091097(TBXAS1)
PTG: 102970130(TBXAS1)
AJU: 106970434(TBXAS1)
BTA: 509326(TBXAS1)
BOM: 102269002(TBXAS1)
BIU: 109557691(TBXAS1)
PHD: 102319354(TBXAS1)
CHX: 102178240(TBXAS1)
OAS: 101111361(TBXAS1)
SSC: 397112(TBXAS1)
CFR: 102522566(TBXAS1)
CDK: 105091642(TBXAS1)
BACU: 103014081(TBXAS1)
LVE: 103076764(TBXAS1)
OOR: 101279392(TBXAS1)
ECB: 100066198(TBXAS1)
EPZ: 103556299(TBXAS1)
EAI: 106842627(TBXAS1)
MYB: 102246253(TBXAS1)
MYD: 102752445(TBXAS1)
HAI: 109388522(TBXAS1)
RSS: 109457346(TBXAS1)
PALE: 102880503(TBXAS1)
LAV: 100666117(TBXAS1)
TMU: 101355205
MDO: 100023523(TBXAS1)
SHR: 100933239(TBXAS1)
OAA: 100087744(TBXAS1)
GGA: 418101(TBXAS1)
MGP: 100547506
CJO: 107316123(TBXAS1)
APLA: 101799380(TBXAS1)
ACYG: 106031025(TBXAS1)
TGU: 100220562(TBXAS1)
GFR: 102033663(TBXAS1)
FAB: 101821781(TBXAS1)
PHI: 102099408(TBXAS1)
PMAJ: 107204806(TBXAS1)
CCAE: 111931337(TBXAS1)
CCW: 104696219(TBXAS1)
FPG: 101921622(TBXAS1)
FCH: 102058879(TBXAS1)
CLV: 102090566(TBXAS1)
EGZ: 104135574(TBXAS1)
AAM: 106488440(TBXAS1)
ASN: 102382949(TBXAS1)
AMJ: 102558059(TBXAS1)
PSS: 102461458(TBXAS1)
CMY: 102935048(TBXAS1)
CPIC: 101953436(TBXAS1)
ACS: 100561371(tbxas1)
PVT: 110082702(TBXAS1)
PBI: 103066404(TBXAS1)
XLA: 108704351 379702 779365(tbxas1.L)
XTR: 100327243(tbxas1)
NPR: 108797764(TBXAS1)
DRE: 792041(tbxas1)
SANH: 107684653
IPU: 108264404(tbxas1)
AMEX: 103045961(tbxas1)
TRU: 101064915(tbxas1)
LCO: 104923716(tbxas1)
NCC: 104950691(tbxas1)
OLA: 101158441(tbxas1)
XMA: 102224720(tbxas1)
PRET: 103481207(tbxas1)
CSEM: 103380419(tbxas1)
SDU: 111228551(tbxas1)
HCQ: 109530412(tbxas1)
MALB: 109961809(tbxas1)
SASA: 100306773(thas) 106561393
ELS: 105018137(tbxas1)
SFM: 108935974(tbxas1)
LCM: 102350410(TBXAS1)
CMK: 103181850(tbxas1)
APLC: 110986196
TSP: Tsp_05911
CRG: 105329919
CRE: CHLREDRAFT_196714(CYP744B1) CHLREDRAFT_196715(CYP744C1)
DFA: DFA_02932(CYP556A1)
 » show all
Taxonomy
Reference
1  [PMID:3745158]
  Authors
Shen RF, Tai HH.
  Title
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung.
  Journal
J Biol Chem 261:11592-9 (1986)
Reference
2  [PMID:6221511]
  Authors
Ullrich V, Haurand M.
  Title
Thromboxane synthase as a cytochrome P450 enzyme.
  Journal
Adv Prostaglandin Thromboxane Leukot Res 11:105-10 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.5
IUBMB Enzyme Nomenclature: 5.3.99.5
ExPASy - ENZYME nomenclature database: 5.3.99.5
BRENDA, the Enzyme Database: 5.3.99.5
CAS: 61276-89-9

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