KEGG   ENZYME: 5.3.99.5Help
Entry
EC 5.3.99.5                 Enzyme                                 

Name
thromboxane-A synthase;
thromboxane synthase;
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase
Class
Isomerases;
Intramolecular oxidoreductases;
Other intramolecular oxidoreductases
BRITE hierarchy
Sysname
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase
Reaction(IUBMB)
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [RN:R02268]
Reaction(KEGG)
Substrate
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate [CPD:C00427]
Product
(5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate [CPD:C02198]
Comment
A cytochrome P-450 heme-thiolate enzyme. Converts prostaglandin H2 into thromboxane A2.
History
EC 5.3.99.5 created 1984, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K01832  thromboxane-A synthase
Genes
HSA: 6916(TBXAS1)
PTR: 463774(TBXAS1)
PPS: 100974860(TBXAS1)
GGO: 101143018(TBXAS1) 109027809
PON: 100173366(TBXAS1)
NLE: 100580072(TBXAS1)
MCC: 711748(TBXAS1)
MCF: 102128548(TBXAS1)
CSAB: 103227005(TBXAS1)
RRO: 104656601(TBXAS1)
RBB: 108534817(TBXAS1)
CJC: 100405880(TBXAS1)
SBQ: 101049596(TBXAS1)
MMU: 21391(Tbxas1)
RNO: 24886(Tbxas1)
CGE: 100772642(Tbxas1)
NGI: 103726097(Tbxas1)
HGL: 101697368(Tbxas1)
CCAN: 109687422(Tbxas1) 109688831
OCU: 100339354(TBXAS1)
TUP: 102482189(TBXAS1)
CFA: 482771(TBXAS1)
AML: 100481563(TBXAS1)
UMR: 103669108(TBXAS1)
ORO: 101374074(TBXAS1)
FCA: 101091097(TBXAS1)
PTG: 102970130(TBXAS1)
AJU: 106970434(TBXAS1)
BTA: 509326(TBXAS1)
BOM: 102269002(TBXAS1)
BIU: 109557691(TBXAS1)
PHD: 102319354(TBXAS1)
CHX: 102178240(TBXAS1)
OAS: 101111361(TBXAS1)
SSC: 397112(TBXAS1)
CFR: 102522566(TBXAS1)
CDK: 105091642(TBXAS1)
BACU: 103014081(TBXAS1)
LVE: 103076764(TBXAS1)
OOR: 101279392(TBXAS1)
ECB: 100066198(TBXAS1)
EPZ: 103556299(TBXAS1)
EAI: 106842627(TBXAS1)
MYB: 102246253(TBXAS1)
MYD: 102752445(TBXAS1)
HAI: 109388522(TBXAS1)
RSS: 109457346(TBXAS1)
PALE: 102880503(TBXAS1)
LAV: 100666117(TBXAS1)
TMU: 101355205
MDO: 100023523(TBXAS1)
SHR: 100933239(TBXAS1)
OAA: 100087744(TBXAS1)
GGA: 418101(TBXAS1)
MGP: 100547506
CJO: 107316123(TBXAS1)
APLA: 101799380(TBXAS1)
ACYG: 106031025(TBXAS1)
TGU: 100220562(TBXAS1)
GFR: 102033663(TBXAS1)
FAB: 101821781(TBXAS1)
PHI: 102099408(TBXAS1)
PMAJ: 107204806(TBXAS1)
CCAE: 111931337(TBXAS1)
CCW: 104696219(TBXAS1)
FPG: 101921622(TBXAS1)
FCH: 102058879(TBXAS1)
CLV: 102090566(TBXAS1)
EGZ: 104135574(TBXAS1)
AAM: 106488440(TBXAS1)
ASN: 102382949(TBXAS1)
AMJ: 102558059(TBXAS1)
PSS: 102461458(TBXAS1)
CMY: 102935048(TBXAS1)
CPIC: 101953436(TBXAS1)
ACS: 100561371(tbxas1)
PVT: 110082702(TBXAS1)
PBI: 103066404(TBXAS1)
GJA: 107119575 107119578
XLA: 108704351 379702 779365(tbxas1.L)
XTR: 100327243(tbxas1)
NPR: 108797764(TBXAS1)
DRE: 792041(tbxas1)
SRX: 107722474 107738402
SANH: 107684653
SGH: 107559817 107587020
CCAR: 109109211 109109645
IPU: 108264404(tbxas1)
AMEX: 103045961(tbxas1)
TRU: 101064915(tbxas1)
TNG: GSTEN00015938G001
LCO: 104923716(tbxas1)
NCC: 104950691(tbxas1)
MZE: 101479408 101479900 101486083
OLA: 101158441(tbxas1)
XMA: 102224720(tbxas1)
PRET: 103481207(tbxas1)
NFU: 107372820 107389081 107395858
KMR: 108237448 108237512 108237513 108237514 108237515
CSEM: 103380419(tbxas1)
LCF: 108875270 108875456 108879784
SDU: 111228551(tbxas1)
HCQ: 109530412(tbxas1)
BPEC: 110161335 110175058 110175059
MALB: 109961809(tbxas1)
SASA: 100306773(thas) 106561393
OTW: 112218751 112252557
ELS: 105018137(tbxas1)
SFM: 108935974(tbxas1)
LCM: 102350410(TBXAS1)
CMK: 103181850(tbxas1)
BFO: BRAFLDRAFT_220935
APLC: 110986196
FCD: 110844454 110862882
DPX: DAPPUDRAFT_328913(TXSB) DAPPUDRAFT_96715(TXSA)
ISC: IscW_ISCW001306 IscW_ISCW006560 IscW_ISCW007658 IscW_ISCW009136 IscW_ISCW010184 IscW_ISCW012810 IscW_ISCW016204 IscW_ISCW016393 IscW_ISCW024107 IscW_ISCW024274 IscW_ISCW024627 IscW_ISCW024674
TSP: Tsp_05911
LGI: LOTGIDRAFT_219061
CRG: 105329919
OBI: 106868827 106868828 106879338 106880759 106882071 106884147 106884149 106884158
LAK: 106154964 106156299 106157103 106157104 106158333 106159562 106159563 106159564 106162400 106162908 106162910 106164157 106171047 106172070 106173825 106177469 106181174
NVE: NEMVE_v1g120897
EPA: 110242041 110244116
AQU: 100631547 100632078 100633087 100633214 100633724 100638571 105312894 105312896 105313394 105314363 105315867 105316160 109581119 109582404 109582639 109586004 109589367 109591120 109591343
CRE: CHLREDRAFT_196714(CYP744B1) CHLREDRAFT_196715(CYP744C1)
MNG: MNEG_1041 MNEG_1042 MNEG_6515
CSL: COCSUDRAFT_39702 COCSUDRAFT_49034 COCSUDRAFT_65415
CVR: CHLNCDRAFT_134405 CHLNCDRAFT_135113 CHLNCDRAFT_135122 CHLNCDRAFT_57715
DFA: DFA_02932(CYP556A1)
 » show all
Taxonomy
Reference
1  [PMID:3745158]
  Authors
Shen RF, Tai HH.
  Title
Immunoaffinity purification and characterization of thromboxane synthase from porcine lung.
  Journal
J Biol Chem 261:11592-9 (1986)
Reference
2  [PMID:6221511]
  Authors
Ullrich V, Haurand M.
  Title
Thromboxane synthase as a cytochrome P450 enzyme.
  Journal
Adv Prostaglandin Thromboxane Leukot Res 11:105-10 (1983)
Other DBs
ExplorEnz - The Enzyme Database: 5.3.99.5
IUBMB Enzyme Nomenclature: 5.3.99.5
ExPASy - ENZYME nomenclature database: 5.3.99.5
BRENDA, the Enzyme Database: 5.3.99.5
CAS: 61276-89-9

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (2)   
   KEGG COMPOUND (2)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (860)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (214)   
   KEGG MGENES (15)   
   RefGene (588)   
   EGENES (42)   
Protein sequence (42)   
   UniProt (14)   
   SWISS-PROT (6)   
   RefSeq(pep) (21)   
   PMD (1)   
DNA sequence (63)   
   RefSeq(nuc) (26)   
   GenBank (22)   
   EMBL (15)   
All databases (973)   

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