KEGG   ENZYME: 5.4.2.9Help
Entry
EC 5.4.2.9                  Enzyme                                 

Name
phosphoenolpyruvate mutase;
phosphoenolpyruvate-phosphonopyruvate phosphomutase;
PEP phosphomutase;
phosphoenolpyruvate phosphomutase;
PEPPM;
PEP phosphomutase
Class
Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)
BRITE hierarchy
Sysname
phosphoenolpyruvate 2,3-phosphonomutase
Reaction(IUBMB)
phosphoenolpyruvate = 3-phosphonopyruvate [RN:R00661]
Reaction(KEGG)
Substrate
phosphoenolpyruvate [CPD:C00074]
Product
3-phosphonopyruvate [CPD:C02798]
Comment
Involved in the biosynthesis of the C-P bond, although the equilibrium greatly favours phosphoenolpyruvate.
History
EC 5.4.2.9 created 1990
Pathway
ec00440  Phosphonate and phosphinate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
ec01130  Biosynthesis of antibiotics
Orthology
K01841  phosphoenolpyruvate phosphomutase
Genes
PHD: 102315746
ZNE: 110838650
FCD: 110846421
LGI: LOTGIDRAFT_228330
CRG: 105327128
MYI: 110459395
OBI: 106868978
LAK: 106181605
NVE: NEMVE_v1g189422
EPA: 110252232
ADF: 107334552
HMG: 100204901
HDE: HDEF_0203
SRL: SOD_c30090(bcpB)
ECA: ECA0487(fom1)
PATR: EV46_02520
PATO: GZ59_05030(fom1)
PCT: PC1_0476
PEC: W5S_0590
SOD: Sant_3984(pepM)
LBQ: CKQ53_06560(aepX)
EPE: CI789_05510(aepX)
PAM: PANA_3291(pepM)
PAJ: PAJ_2522
PLU: plu1865
XBV: XBW1_2042
XDO: XDD1_1002(PEPM)
XVA: C7V42_03530(aepX)
VFI: VF_1249
PSYR: N018_11280
PFL: PFL_2141(aepX)
PPRC: PFLCHA0_c21830(pphA)
PPRO: PPC_2159(aepX)
PFC: PflA506_4617(aepX)
PEN: PSEEN3956
PSOS: POS17_2086(aepX)
SDN: Sden_1161
NOC: Noc_1317
NHL: Nhal_1306
NWA: Nwat_1199
HAM: HALO1617
RME: Rmet_1808(pepM)
BMA: BMAA1768(pepM)
BMV: BMASAVP1_0758(pepM)
BML: BMA10229_1051(pepM)
BMN: BMA10247_A2026(pepM)
BMAL: DM55_4014(aepX)
BMAQ: DM76_4710(aepX)
BMAI: DM57_07165
BMAF: DM51_3461(aepX)
BMAZ: BM44_3974(aepX)
BMAB: BM45_4751(aepX)
BPM: BURPS1710b_A2065(pepM)
BPSE: BDL_3735(aepX) BDL_3837(aepX)
BPSM: BBQ_5585(aepX) BBQ_5687(aepX)
BPSU: BBN_3909(aepX) BBN_4009(aepX)
BPSD: BBX_5572(aepX) BBX_5674(aepX)
BPK: BBK_3881(aepX) BBK_5714(aepX)
BPSH: DR55_4742(aepX) DR55_4843(aepX)
BPSA: BBU_5436(aepX) BBU_5538(aepX)
BPSO: X996_3790(aepX) X996_4593(aepX)
BUT: X994_4009(aepX) X994_4111(aepX)
BTQ: BTQ_5190(aepX)
BTJ: BTJ_3820(aepX)
BTZ: BTL_4576(aepX) BTL_4676(aepX)
BTD: BTI_5338(aepX) BTI_5422
BTV: BTHA_5553(aepX)
BTHE: BTN_4315(aepX)
BTHM: BTRA_4580(aepX)
BTHL: BG87_4647(aepX)
BOK: DM82_2520(aepX) DM82_4611(aepX) DM82_4705(aepX) DM82_5468(aepX)
BOC: BG90_2213(aepX) BG90_5140(aepX) BG90_5888(aepX) BG90_5980(aepX)
BVE: AK36_4232(aepX)
BCN: Bcen_4245
BCJ: BCAM1245
BCEN: DM39_3753(aepX)
BCEW: DM40_4163(aepX)
BCEO: I35_5094
BAM: Bamb_3535
BMU: Bmul_4471
BMK: DM80_3632(aepX)
BMUL: NP80_4148(aepX)
BCT: GEM_4495
BCED: DM42_3846(aepX)
BDL: AK34_4230(aepX)
BCON: NL30_06370
BUB: BW23_4919(aepX)
BLAT: WK25_23150
BTEI: WS51_03920
BSEM: WJ12_26085
BPSL: WS57_07790
BMEC: WJ16_24710
BGU: KS03_4595(aepX)
BGO: BM43_5003(aepX)
BUK: MYA_4542
BUL: BW21_5018(aepX)
BXE: Bxe_B2235
BXB: DR64_4566(aepX)
BPH: Bphy_3822
BFN: OI25_4536(aepX)
PARB: CJU94_32420(aepX)
PHS: C2L64_30760(aepX)
PTER: C2L65_27420(aepX)
PGP: CUJ91_19555(aepX)
PPNO: DA70_09035
PPNM: LV28_21770
PSPU: NA29_20990
PAPI: SG18_00140
BPAR: BN117_3742(pepM)
BBR: BB1046(pepM)
BBM: BN115_0996(pepM)
BBH: BN112_2401(pepM)
BBX: BBS798_1016(pepM)
BHO: D560_3796
BHM: D558_3769
BHZ: ACR54_02067(pphA_1)
AXX: ERS451415_04691(pphA_2)
AFQ: AFA_00195
AAV: Aave_3887
AAA: Acav_2122
AZO: azo2698(pepM)
AOA: dqs_2833
HCP: HCN_1062
CHYO: CHH_1593
CHW: A2J15_004815(aepX)
PCA: Pcar_0628
PPD: Ppro_2167
DAL: Dalk_1323
SCL: sce7305(pepM)
BSTO: C0V70_16040(aepX)
ARA: Arad_7864
AVI: Avi_3412
AOL: S58_09510
RPC: RPC_3871
ROS: CTJ15_07640(aepX)
MAGX: XM1_0907(pepM)
TMO: TMO_b0348
BSS: BSUW23_01000(rhiH)
BYA: BANAU_0589(pepM)
BAMB: BAPNAU_0598(pepM)
BMP: NG74_00659(pphA)
BQY: MUS_0647
BMQ: BMQ_0784(aepX)
BMD: BMD_0785(aepX)
BMEG: BG04_3078(aepX)
BACB: OY17_06005
PPOL: X809_41430
PLV: ERIC2_c18340(bcpB) ERIC2_c19750(pphA)
TAB: CIG75_00855(aepX) CIG75_11125(aepX)
CTC: CTC_01698
CBE: Cbei_4338
CBZ: Cbs_4338
CBEI: LF65_04862
CSR: Cspa_c46190(ppm)
CSB: CLSA_c08730(ppm)
RCH: RUM_11420
RIX: RO1_19910
SDV: BN159_4099(pphA)
SALS: SLNWT_1191
SALF: SMD44_04407(pepM)
KSK: KSE_22660
FAL: FRAAL6377
KAL: KALB_5539
ACTA: C1701_23200(aepX)
SAQ: Sare_1956
SNA: Snas_5665
OLS: Olsu_0594
OBG: Verru16b_03222(pphA)
TDE: TDE1413
BIP: Bint_1240
FSC: FSU_1439
BTH: BT_1720
BTHO: Btheta7330_01295(pphA)
BFS: BF9343_1814(aepX)
NDE: NIDE2903
NMV: NITMOv2_0598(pepM)
NJA: NSJP_1710
NMR: Nmar_0160
NCT: NMSP_0156
 » show all
Taxonomy
Reference
1
  Authors
Bowman, E., McQueney, M., Barry, R.J. and Dunaway-Mariano, D.
  Title
Catalysis and thermodynamics of the phosphoenolpyruvate phosphonopyruvate rearrangement - entry into the phosphonate class of naturally-occurring organo-phosphorus compounds.
  Journal
J Am Chem Soc 110:5575-5576 (1988)
Reference
2  [PMID:2160937]
  Authors
Hidaka T, Imai S, Hara O, Anzai H, Murakami T, Nagaoka K, Seto H.
  Title
Carboxyphosphonoenolpyruvate phosphonomutase, a novel enzyme catalyzing C-P bond formation.
  Journal
J Bacteriol 172:3066-72 (1990)
DOI:10.1128/JB.172.6.3066-3072.1990
Reference
3  [PMID:3138545]
  Authors
Seidel HM, Freeman S, Seto H, Knowles JR.
  Title
Phosphonate biosynthesis: isolation of the enzyme responsible for the formation of a carbon-phosphorus bond.
  Journal
Nature 335:457-8 (1988)
DOI:10.1038/335457a0
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.4.2.9
IUBMB Enzyme Nomenclature: 5.4.2.9
ExPASy - ENZYME nomenclature database: 5.4.2.9
BRENDA, the Enzyme Database: 5.4.2.9
CAS: 115756-49-5

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