KEGG   ENZYME: 5.4.3.9Help
Entry
EC 5.4.3.9                  Enzyme                                 

Name
glutamate 2,3-aminomutase
Class
Isomerases;
Intramolecular transferases;
Transferring amino groups
BRITE hierarchy
Sysname
L-glutamate 2,3-aminomutase
Reaction(IUBMB)
L-glutamate = 3-aminopentanedioate [RN:R10153]
Reaction(KEGG)
Substrate
L-glutamate [CPD:C00025]
Product
3-aminopentanedioate [CPD:C05574]
Comment
This enzyme is a member of the 'AdoMet radical' (radical SAM) family. It contains pyridoxal phosphate and a [4Fe-4S] cluster, which is coordinated by 3 cysteines and binds an exchangeable S-adenosyl-L-methionine molecule. During the reaction cycle, the AdoMet forms a 5'-deoxyadenosyl radical, which is regenerated at the end of the reaction.
History
EC 5.4.3.9 created 2012
Orthology
K19814  glutamate 2,3-aminomutase
Genes
CCB: Clocel_2678
CACE: CACET_c07510(kamA1)
CFM: BJL90_09905
AMT: Amet_2738
HSC: HVS_09740(eam)
CSS: Cst_c09560(kamA1)
CSD: Clst_0916
CSH: Closa_2267
CDF: CD630_22520(kamA)
PDC: CDIF630_02487(eam)
CDC: CD196_2109(kamA)
CDL: CDR20291_2152(kamA)
PDF: CD630DERM_22520(kamA)
SWO: Swol_1121
SLP: Slip_1437
DSY: DSY4027
DHD: Dhaf_1337
DRM: Dred_2148
PTH: PTH_0616(KamA)
DAU: Daud_1068
SGY: Sgly_2707
TTE: TTE1204(KamA2)
CHY: CHY_2479
MTA: Moth_0457
ADG: Adeg_1408
TPZ: Tph_c22230(kamA)
CSC: Csac_0232
ATE: Athe_2274
CAD: Curi_c04320(kamA)
MMIL: sm9_1912
MEYE: TL18_07795
 » show all
Taxonomy
Reference
1  [PMID:17222594]
  Authors
Ruzicka FJ, Frey PA
  Title
Glutamate 2,3-aminomutase: a new member of the radical SAM superfamily of enzymes.
  Journal
Biochim Biophys Acta 1774:286-96 (2007)
DOI:10.1016/j.bbapap.2006.11.008
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.4.3.9
IUBMB Enzyme Nomenclature: 5.4.3.9
ExPASy - ENZYME nomenclature database: 5.4.3.9
BRENDA, the Enzyme Database: 5.4.3.9

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