KEGG   ENZYME: 5.4.99.32Help
Entry
EC 5.4.99.32                Enzyme                                 

Name
protostadienol synthase;
PdsA;
(S)-2,3-epoxysqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase [cyclizing, (17Z)-protosta-17(20),24-dien-3beta-ol-forming]
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = (17Z)-protosta-17(20),24-dien-3beta-ol [RN:R09689]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
(17Z)-protosta-17(20),24-dien-3beta-ol [CPD:C19820]
Comment
(17Z)-Protosta-17(20),24-dien-3beta-ol is a precursor of the steroidal antibiotic helvolic acid.
History
EC 5.4.99.32 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K15811  protostadienol synthase
Genes
MAJ: MAA_06587
AFM: AFUA_4G14770
NFI: NFIA_101360
Taxonomy
Reference
1  [PMID:19216560]
  Authors
Lodeiro S, Xiong Q, Wilson WK, Ivanova Y, Smith ML, May GS, Matsuda SP
  Title
Protostadienol biosynthesis and metabolism in the pathogenic fungus Aspergillus fumigatus.
  Journal
Org Lett 11:1241-4 (2009)
DOI:10.1021/ol802696a
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.32
IUBMB Enzyme Nomenclature: 5.4.99.32
ExPASy - ENZYME nomenclature database: 5.4.99.32
BRENDA, the Enzyme Database: 5.4.99.32

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