KEGG   ENZYME: 5.4.99.4Help
Entry
EC 5.4.99.4                 Enzyme                                 

Name
2-methyleneglutarate mutase;
alpha-methyleneglutarate mutase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
2-methyleneglutarate carboxy-methylenemethylmutase
Reaction(IUBMB)
2-methyleneglutarate = 2-methylene-3-methylsuccinate [RN:R03908]
Reaction(KEGG)
Substrate
2-methyleneglutarate [CPD:C02930]
Product
2-methylene-3-methylsuccinate [CPD:C02295]
Comment
Requires a cobamide coenzyme.
History
EC 5.4.99.4 created 1972
Pathway
ec00760  Nicotinate and nicotinamide metabolism
ec01120  Microbial metabolism in diverse environments
Orthology
K20450  2-methyleneglutarate mutase
Genes
DOR: Desor_0455
TEP: TepRe1_0402
TAE: TepiRe1_0446(mgm)
NTH: Nther_2157
Taxonomy
Reference
1  [PMID:5266166]
  Authors
Kung HF, Cederbaum S, Tsai L, Stadtman TC.
  Title
Nicotinic acid metabolism. V. A cobamide coenzyme-dependent conversion of alpha-methyleneglutaric acid to dimethylmaleic acid.
  Journal
Proc Natl Acad Sci U S A 65:978-84 (1970)
DOI:10.1073/pnas.65.4.978
Reference
2  [PMID:5574401]
  Authors
Kung HF, Stadtman TC.
  Title
Nicotinic acid metabolism. VI. Purification and properties of alpha-methyleneglutarate mutase (B 12-dependent) and methylitaconate isomerase.
  Journal
J Biol Chem 246:3378-88 (1971)
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.4
IUBMB Enzyme Nomenclature: 5.4.99.4
ExPASy - ENZYME nomenclature database: 5.4.99.4
BRENDA, the Enzyme Database: 5.4.99.4
CAS: 9059-10-3

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