KEGG   ENZYME: 5.4.99.53Help
Entry
EC 5.4.99.53                Enzyme                                 

Name
marneral synthase
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, marneral-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = marneral [RN:R09913]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
marneral [CPD:C20192]
Comment
Marneral is a triterpenoid formed by Grob fragmentation of the A ring of 2,3-epoxy-2,3-dihydrosqualene during cyclization.
History
EC 5.4.99.53 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K16207  marneral synthase
Genes
ATH: AT5G42600(MRN1)
Taxonomy
Reference
1  [PMID:16425307]
  Authors
Xiong Q, Wilson WK, Matsuda SP
  Title
An Arabidopsis oxidosqualene cyclase catalyzes iridal skeleton formation by Grob  fragmentation.
  Journal
Angew Chem Int Ed Engl 45:1285-8 (2006)
DOI:10.1002/anie.200503420
  Sequence
[ath:AT5G42600]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.53
IUBMB Enzyme Nomenclature: 5.4.99.53
ExPASy - ENZYME nomenclature database: 5.4.99.53
BRENDA, the Enzyme Database: 5.4.99.53

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