KEGG   ENZYME: 5.4.99.56Help
Entry
EC 5.4.99.56                Enzyme                                 

Name
tirucalladienol synthase;
PEN3
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, tirucalla-7,24-dien-3beta-ol-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = tirucalla-7,24-dien-3beta-ol [RN:R09916]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
tirucalla-7,24-dien-3beta-ol [CPD:C20195]
Comment
The product from Arabidopsis thaliana is 85% tirucalla-7,24-dien-3beta-ol with trace amounts of other triterpenoids.
History
EC 5.4.99.56 created 2011
Pathway
ec00909  Sesquiterpenoid and triterpenoid biosynthesis
Orthology
K16205  tirucalladienol synthase
Genes
ATH: AT5G36150(PEN3)
ALY: ARALYDRAFT_664809
CRB: 17886185
CSAT: 104773008
EUS: EUTSA_v10017701mg
BRP: 103864450
BOE: 106338910
Taxonomy
Reference
1  [PMID:19445469]
  Authors
Morlacchi P, Wilson WK, Xiong Q, Bhaduri A, Sttivend D, Kolesnikova MD, Matsuda SP
  Title
Product profile of PEN3: the last unexamined oxidosqualene cyclase in Arabidopsis thaliana.
  Journal
Org Lett 11:2627-30 (2009)
DOI:10.1021/ol9005745
  Sequence
[ath:AT5G36150]
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.56
IUBMB Enzyme Nomenclature: 5.4.99.56
ExPASy - ENZYME nomenclature database: 5.4.99.56
BRENDA, the Enzyme Database: 5.4.99.56

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