KEGG   ENZYME: 5.4.99.58Help
Entry
EC 5.4.99.58                Enzyme                                 

Name
methylornithine synthase;
PylB
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
L-lysine carboxy-aminomethylmutase
Reaction(IUBMB)
L-lysine = (3R)-3-methyl-D-ornithine [RN:R10010]
Reaction(KEGG)
Substrate
L-lysine [CPD:C00047]
Product
(3R)-3-methyl-D-ornithine [CPD:C20277]
Comment
The enzyme is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes. Binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule. The reaction is part of the biosynthesis pathway of pyrrolysine, a naturally occurring amino acid found in some archaeal methyltransferases.
History
EC 5.4.99.58 created 2012
Pathway
ec00300  Lysine biosynthesis
ec01120  Microbial metabolism in diverse environments
Orthology
K16180  methylornithine synthase
Genes
DAT: HRM2_15240(bioB2)
DSY: DSY4958
DHD: Dhaf_4857
DDH: Desde_0574
DAE: Dtox_0028
DGI: Desgi_3925
TJR: TherJR_0023
DOR: Desor_1148 Desor_1623 Desor_3055
DMI: Desmer_1592 Desmer_2996
TPZ: Tph_c27770
MEAR: Mpt1_c05690(pylB2)
MARC: AR505_1324
MAC: MA_0154(bioB)
MBAR: MSBR2_2225
MBAK: MSBR3_2276
MMA: MM_1444
MMAC: MSMAC_3242
METM: MSMTP_3120
MTHE: MSTHC_1350
MTHR: MSTHT_1933
MHOR: MSHOH_3966
MBU: Mbur_2085(pylB)
MMET: MCMEM_0284
MMH: Mmah_0282
MPY: Mpsy_1722(bioB)
 » show all
Taxonomy
Reference
1  [PMID:21455182]
  Authors
Gaston MA, Zhang L, Green-Church KB, Krzycki JA
  Title
The complete biosynthesis of the genetically encoded amino acid pyrrolysine from  lysine.
  Journal
Nature 471:647-50 (2011)
DOI:10.1038/nature09918
  Sequence
[mac:MA_0154]
Reference
2  [PMID:22095926]
  Authors
Quitterer F, List A, Eisenreich W, Bacher A, Groll M
  Title
Crystal structure of methylornithine synthase (PylB): insights into the pyrrolysine biosynthesis.
  Journal
Angew Chem Int Ed Engl 51:1339-42 (2012)
DOI:10.1002/anie.201106765
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.58
IUBMB Enzyme Nomenclature: 5.4.99.58
ExPASy - ENZYME nomenclature database: 5.4.99.58
BRENDA, the Enzyme Database: 5.4.99.58

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