KEGG   ENZYME: 5.4.99.7Help
Entry
EC 5.4.99.7                 Enzyme                                 

Name
lanosterol synthase;
2,3-epoxysqualene lanosterol cyclase;
squalene-2,3-oxide-lanosterol cyclase;
lanosterol 2,3-oxidosqualene cyclase;
squalene 2,3-epoxide:lanosterol cyclase;
2,3-oxidosqualene sterol cyclase;
oxidosqualene cyclase;
2,3-oxidosqualene cyclase;
2,3-oxidosqualene-lanosterol cyclase;
oxidosqualene-lanosterol cyclase;
squalene epoxidase-cyclase;
(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, lanosterol-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = lanosterol [RN:R03199]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
lanosterol [CPD:C01724]
History
EC 5.4.99.7 created 1961 as EC 1.99.1.13, transferred 1965 to EC 1.14.1.3, part transferred 1972 to EC 5.4.99.7 rest to EC 1.14.99.7
Pathway
ec00100  Steroid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K01852  lanosterol synthase
Genes
HSA: 4047(LSS)
PTR: 474058(LSS)
PPS: 100974593(LSS)
GGO: 101124004(LSS)
PON: 100432375(LSS)
NLE: 100592843(LSS)
MCC: 709227(LSS)
MCF: 102137329(LSS)
CSAB: 103220328(LSS)
RRO: 104667600(LSS)
RBB: 108512153
CJC: 100409467(LSS)
SBQ: 101032145(LSS)
MMU: 16987(Lss)
RNO: 81681(Lss)
CGE: 100753498(Lss)
NGI: 103739961(Lss)
HGL: 101713900(Lss)
CCAN: 109695890(Lss)
OCU: 100359315(LSS)
TUP: 102473663(LSS)
CFA: 491611(LSS)
AML: 100482594(LSS)
UMR: 103680679(LSS)
ORO: 101375055(LSS)
FCA: 101080651(LSS)
PTG: 102962591(LSS)
AJU: 106987528(LSS)
BTA: 615906(LSS)
BOM: 102277039(LSS)
BIU: 109561307(LSS)
PHD: 102343626(LSS)
CHX: 102175810(LSS)
OAS: 101106995(LSS)
SSC: 100625138(LSS)
CFR: 102516637(LSS)
CDK: 105090588(LSS)
BACU: 103005228(LSS)
LVE: 103077252(LSS)
OOR: 101289294(LSS)
ECB: 100055292(LSS)
EPZ: 103558417(LSS)
EAI: 106842988(LSS)
MYB: 102244769(LSS)
MYD: 102755441(LSS)
HAI: 109373831(LSS)
RSS: 109438027(LSS)
PALE: 102897618(LSS)
LAV: 100662429(LSS)
TMU: 101341011
MDO: 100026255(LSS)
SHR: 100933933(LSS)
OAA: 100083602(LSS)
GGA: 424037(LSS)
MGP: 100544500(LSS)
CJO: 107316378(LSS)
APLA: 101801199(LSS)
ACYG: 106030113(LSS)
TGU: 100223318(LSS)
GFR: 102037340(LSS)
FAB: 101809334(LSS)
PHI: 102113695(LSS)
PMAJ: 107207178(LSS)
CCW: 104698254(LSS)
FPG: 101912237(LSS)
FCH: 102059359(LSS)
CLV: 102092351(LSS)
EGZ: 104133503(LSS)
AAM: 106486829 106492318(LSS)
ASN: 102375533(LSS)
AMJ: 102568061(LSS)
PSS: 102456254(LSS)
CMY: 102946034(LSS)
ACS: 100558321(lss)
PBI: 103051351(LSS) 103060199
GJA: 107122323(LSS)
XLA: 108703025(lss.S)
XTR: 733925(lss)
NPR: 108793617(LSS)
DRE: 795400(lss)
SGH: 107555930(lss) 107596088
CCAR: 109088812(lss)
IPU: 108266196(lss)
AMEX: 103022113(lss)
TRU: 101062227(lss)
LCO: 104920782(lss)
NCC: 104947466 104957277(lss)
MZE: 101485469(lss)
OLA: 101157258 101157497(lss)
XMA: 102229476(lss)
PRET: 103461854(lss)
NFU: 107373714(lss)
CSEM: 103392388(lss)
LCF: 108897198(lss)
HCQ: 109517560(lss)
BPEC: 110167885(lss)
SASA: 106581851(lss)
ELS: 105016172(lss)
SFM: 108924262(lss)
LCM: 102361349(LSS)
CMK: 103188931(lss)
SPU: 576764
APLC: 110975212
SKO: 100368395
AQU: 100636608
ATH: AT3G45130(LAS1)
THJ: 104799632
PXB: 103937095
SCE: YHR072W(ERG7)
ERC: Ecym_8182
KMX: KLMA_30341(ERG7)
NCS: NCAS_0H01640(NCAS0H01640)
NDI: NDAI_0C01970(NDAI0C01970)
TPF: TPHA_0E01120(TPHA0E01120)
TBL: TBLA_0A03120(TBLA0A03120)
TDL: TDEL_0E02760(TDEL0E02760)
KAF: KAFR_0D04670(KAFR0D04670)
PIC: PICST_77382(ERG7)
CAL: CAALFM_C202460WA(ERG7)
CDU: CD36_17130(ERG7)
CAUR: QG37_01141
SLB: AWJ20_3290(ERG7)
NCR: NCU01119
NTE: NEUTE1DRAFT127722(NEUTE1DRAFT_127722)
MGR: MGG_11702
SSCK: SPSK_05974
CMT: CCM_09526
MBE: MBM_02694
ANG: ANI_1_1064084(An09g01330) ANI_1_846084(An09g06490)
ABE: ARB_06777
TVE: TRV_05691
PTE: PTT_15458
ZTR: MYCGRDRAFT_110629(ERG7)
SPO: SPAC13G7.01c(erg7)
CNE: CND02520
CNB: CNBD3820
ABP: AGABI1DRAFT55056(AGABI1DRAFT_55056)
ABV: AGABI2DRAFT206259(AGABI2DRAFT_206259)
MGL: MGL_1532
DDI: DDB_G0269226(cas1)
DFA: DFA_02676(cas1)
SMIN: v1.2.027161.t1(symbB.v1.2.027161.t1)
CCX: COCOR_01777(cas)
GES: VT84_21370(shc_3)
 » show all
Taxonomy
Reference
1  [PMID:6027261]
  Authors
Dean PD, Ortiz de Montellano PR, Bloch K, Corey EJ.
  Title
A soluble 2,3-oxidosqualene sterol cyclase.
  Journal
J Biol Chem 242:3014-5 (1967)
Other DBs
ExplorEnz - The Enzyme Database: 5.4.99.7
IUBMB Enzyme Nomenclature: 5.4.99.7
ExPASy - ENZYME nomenclature database: 5.4.99.7
BRENDA, the Enzyme Database: 5.4.99.7
CAS: 9032-71-7

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