KEGG   ENZYME: 5.5.1.1Help
Entry
EC 5.5.1.1                  Enzyme                                 

Name
muconate cycloisomerase;
muconate cycloisomerase I;
cis,cis-muconate-lactonizing enzyme;
cis,cis-muconate cycloisomerase;
muconate lactonizing enzyme;
4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing);
CatB;
MCI;
2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing);
2,5-dihydro-5-oxofuran-2-acetate lyase (ring-opening)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
(+)-muconolactone lyase (ring-opening)
Reaction(IUBMB)
(+)-muconolactone = cis,cis-muconate [RN:R03959]
Reaction(KEGG)
Substrate
(+)-muconolactone [CPD:C14610]
Product
cis,cis-muconate [CPD:C02480]
Comment
Requires Mn2+. Also acts (in the reverse reaction) on 3-methyl-cis,cis-muconate and, very slowly, on cis,trans-muconate. Not identical with EC 5.5.1.7 (chloromuconate cycloisomerase) or EC 5.5.1.11 (dichloromuconate cycloisomerase).
History
EC 5.5.1.1 created 1961
Pathway
ec00361  Chlorocyclohexane and chlorobenzene degradation
ec00362  Benzoate degradation
ec00364  Fluorobenzoate degradation
ec00623  Toluene degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01856  muconate cycloisomerase
Genes
EFE: EFER_1479(catB)
EAS: Entas_2470
KPN: KPN_01875
KPU: KP1_2941
KPM: KPHS_28450
KPP: A79E_2370
KPH: KPNIH24_14180
KPZ: KPNIH27_13600
KPV: KPNIH29_14270
KPW: KPNIH30_14535
KPT: VK055_0608(catB)
KPE: KPK_2481(catB)
KPR: KPR_2939
KPJ: N559_2415
KPX: PMK1_04216(catB)
KPNU: LI86_12020
KPNK: BN49_2975(catB)
KVA: Kvar_2429
EAE: EAE_19910
EAR: CCG29898
EBF: D782_2127
SMAF: D781_2844
PAE: PA2509(catB)
PAEV: N297_2580(catB)
PAEI: N296_2580(catB)
PAU: PA14_32220(catB)
PAP: PSPA7_2730(catB)
PAG: PLES_27861(catB)
PAF: PAM18_2530(catB)
PNC: NCGM2_3512(catB)
PAEB: NCGM1900_4020(catB)
PAEP: PA1S_13100
PAEM: U769_12680
PAEL: T223_14300
PAEU: BN889_02733(catB)
PAEG: AI22_20820
PAEC: M802_2577(catB)
PAEO: M801_2445(catB)
PMK: MDS_4188
PRE: PCA10_14850(catB)
PCQ: PcP3B5_23410(catB)
PPU: PP_3715(catB)
PPF: Pput_2053
PPT: PPS_3181
PPUH: B479_15785
PPUT: L483_19285
PPUN: PP4_21170(catB)
PPUD: DW66_3452
PMON: X969_15295
PMOT: X970_14940
PFL: PFL_3862(catB)
PPRC: PFLCHA0_c39200(catB)
PPRO: PPC_3958(catB)
PFO: Pfl01_2325(catB) Pfl01_2963(catB)
PFS: PFLU_5192
PFC: PflA506_4484(catB)
PFW: PF1751_v1c46420(catB)
PFB: VO64_2032
PMAN: OU5_6160(catB)
PEN: PSEEN3138(catB)
PSA: PST_1672(catB)
PSZ: PSTAB_1582(catB)
PSR: PSTAA_1700(catB)
PPUU: PputUW4_03261(catB)
PKC: PKB_2105(catB)
PSES: PSCI_4928
PSEM: TO66_21125
PSOS: POS17_3983(catB)
PANR: A7J50_4937
PSET: THL1_1537
PSIL: PMA3_10950
PALI: A3K91_1581
ACB: A1S_1843
ABM: ABSDF1994(catB)
ABY: ABAYE1720(catB)
ABN: AB57_2179
ABX: ABK1_2423
ABH: M3Q_2304
ABAD: ABD1_18670(catB)
ABAZ: P795_7685
ABAU: IX87_20690
ABAA: IX88_11400
ACC: BDGL_001323(catB)
ACI: ACIAD1446(catB)
ASJ: AsACE_CH01471(catB)
MHC: MARHY0275(catB)
HBE: BEI_0569(catB1) BEI_1513(catB2)
OCE: GU3_01745
RSC: RCFBP_11865(catB)
RSL: RPSI07_1890(catB)
RSN: RSPO_c01865(dgoAb)
RPI: Rpic_1361
REH: H16_A1966(catB3) H16_B0536(catB4) PHG394(catB2) PHG405(catB1)
CNC: CNE_1c19360(catB) CNE_2c04820(catB) CNE_BB1p12420(catB)
RME: Rmet_4878(catB)
CGD: CR3_3275(catB)
BMA: BMAA0200(catB)
BMV: BMASAVP1_1375(catB)
BML: BMA10229_1571(catB)
BMN: BMA10247_A0231(catB)
BMAL: DM55_3517
BMAE: DM78_4640
BMAQ: DM76_4214
BMAI: DM57_14380
BMAF: DM51_3952
BMAZ: BM44_3479
BMAB: BM45_4315
BPS: BPSS1891(catB)
BPM: BURPS1710b_A0986(catB)
BPL: BURPS1106A_A2566(catB)
BPD: BURPS668_A2710(catB)
BPSE: BDL_5296
BPSM: BBQ_4240
BPSU: BBN_5355(catB)
BPSD: BBX_4461(catB)
BPZ: BP1026B_II2030(catB)
BPK: BBK_4629(catB)
BPSH: DR55_5844
BPSA: BBU_4119(catB)
BPSO: X996_5642
BUT: X994_5205
BTQ: BTQ_3777(catB)
BTJ: BTJ_4808(catB)
BTZ: BTL_5594(catB)
BTD: BTI_5099(catB)
BTV: BTHA_4607(catB)
BTHE: BTN_5265(catB)
BTHM: BTRA_5535(catB)
BTHA: DR62_5394
BTHL: BG87_5610
BOK: DM82_6180
BOC: BG90_4484
BVE: AK36_4536
BCN: Bcen_4593
BCJ: BCAM0805(catB1) BCAS0498(catB2)
BCEN: DM39_4374 DM39_5088(catB)
BCEW: DM40_3779(catB) DM40_5138(catB)
BCEO: I35_4703(catB1) I35_7542(catB2)
BCT: GEM_4993
BCED: DM42_4281(catB) DM42_7062(catB)
BDL: AK34_4637
BUB: BW23_4528
BSTG: WT74_23075
BGP: BGL_2c21070(catB)
BGU: KS03_5206
BGO: BM43_5910(catB)
BUL: BW21_4635
BXE: Bxe_A2108(catB)
BXB: DR64_4263
BPH: Bphy_4029
BFN: OI25_3700
PLG: NCTC10937_02987(catB)
BPT: Bpet1401(catB1) Bpet3349(catB3)
BHO: D560_1118(catB)
BHM: D558_1105(catB)
BHZ: ACR54_04056(catB)
BTRM: SAMEA390648701947(catB1) SAMEA390648702396(catB3_1) SAMEA390648702879(catB3_2)
AXY: AXYL_01797(catB)
AXX: ERS451415_03028(catB)
AMIM: MIM_c30880(catB)
AFQ: AFA_08245
POL: Bpro_4404
PNA: Pnap_2119
AAV: Aave_0199
AJS: Ajs_0140
AAA: Acav_0245
ACRA: BSY15_1221
DAC: Daci_1870
CTES: O987_00600
HSE: Hsero_1306(catB2) Hsero_3665(catB2)
HRB: Hrubri_1132(catB)
CARE: LT85_0143
MES: Meso_2396
AMIH: CO731_00672(catB_1) CO731_02650(catB_2) CO731_05395(catB_3)
SME: SMa1461
SFD: USDA257_c54480(catB)
RHK: Kim5_CH01091(catB)
SHZ: shn_28810
BJA: blr8121
BRS: S23_66510
AZC: AZC_0819
MNO: Mnod_2373
SIL: SPO3667(catB)
JAN: Jann_1408
PDE: Pden_1174
CID: P73_1121
RHC: RGUI_0197
RMM: ROSMUCSMR3_03740(catB)
NAR: Saro_3828
NRE: BES08_19605(catB)
SWI: Swit_0975
SPHM: G432_15115
SJP: SJA_C1-25200(catB)
SPHR: BSY17_110
SINB: SIDU_04795
BLAS: BSY18_3986
ALI: AZOLI_p11001(catB)
TMO: TMO_b0059
BACO: OXB_2692
BEO: BEH_06740
BKW: BkAM31D_16425(catB)
CGL: NCgl2318(Cgl2401)
CGB: cg2635(catB)
CGU: WA5_2318(CatB)
CGT: cgR_2283
CGM: cgp_2635(catB)
CGJ: AR0_11500
CEF: CE2303
CGY: CGLY_10690(catB)
CMQ: B840_09730(catB)
CDX: CDES_10920(catB)
CAMG: CAMM_12510
RHA: RHA1_ro02372(catB)
RER: RER_54220(catB)
REY: O5Y_25765
ROP: ROP_20860(catB)
RRT: 4535765_04630(catB)
SBH: SBI_00699
MPH: MLP_40790(catB)
SEN: SACE_4412
AMD: AMED_5071
AMN: RAM_25825
AMM: AMES_5011
AMZ: B737_5011
AMQ: AMETH_6116(menC)
ACTI: UA75_13960
ACAD: UA74_13875
ALL: CRK57928
RXY: Rxyl_3044
CWO: Cwoe_2943
TTH: TT_C1473
RBA: RB10855
GES: VT84_23185(catB)
 » show all
Taxonomy
Reference
1  [PMID:5330966]
  Authors
Ornston LN.
  Title
The conversion of catechol and protocatechuate to beta-ketoadipate by Pseudomonas putida. 3. Enzymes of the catechol pathway.
  Journal
J Biol Chem 241:3795-9 (1966)
Reference
2
  Authors
Ornston, L.N.
  Title
Conversion of catechol and protocatechuate to beta-ketoadipate (Pseudomonas putida).
  Journal
Methods Enzymol 17A:529-549 (1970)
Reference
3  [PMID:13211620]
  Authors
SISTROM WR, STANIER RY.
  Title
The mechanism of formation of beta-ketoadipic acid by bacteria.
  Journal
J Biol Chem 210:821-36 (1954)
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.1
IUBMB Enzyme Nomenclature: 5.5.1.1
ExPASy - ENZYME nomenclature database: 5.5.1.1
UM-BBD (Biocatalysis/Biodegradation Database): 5.5.1.1
BRENDA, the Enzyme Database: 5.5.1.1
CAS: 9023-72-7

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