KEGG   ENZYME: 5.5.1.16Help
Entry
EC 5.5.1.16                 Enzyme                                 

Name
halimadienyl-diphosphate synthase;
Rv3377c;
halimadienyl diphosphate synthase;
tuberculosinol diphosphate synthase;
halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing);
halima-5,13-dien-15-yl-diphosphate lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
halima-5,13-dien-15-yl-diphosphate lyase (ring-opening)
Reaction(IUBMB)
geranylgeranyl diphosphate = tuberculosinyl diphosphate [RN:R09715]
Reaction(KEGG)
Substrate
geranylgeranyl diphosphate [CPD:C00353]
Product
tuberculosinyl diphosphate [CPD:C19836]
Comment
Requires Mg2+ for activity. This enzyme is found in pathogenic prokaryotes such as Mycobacterium tuberculosis but not in non-pathogens such as Mycobacterium smegmatis so may play a role in pathogenicity. The product of the reaction is subsequently dephosphorylated yielding tuberculosinol (halima-5,13-dien-15-ol).
History
EC 5.5.1.16 created 2008, modified 2012
Orthology
K17811  halimadienyl-diphosphate synthase
Genes
MTU: Rv3377c
MTV: RVBD_3377c
MTC: MT3487
MRA: MRA_3417
MTF: TBFG_13413
MTB: TBMG_03428
MTK: TBSG_03451
MTZ: TBXG_003405
MTG: MRGA327_20845
MTI: MRGA423_21275
MTUR: CFBS_3579
MTD: UDA_3377c
MTUC: J113_23645
MTUE: J114_18110
MTUH: I917_23745
MTUL: TBHG_03315
MTUT: HKBT1_3566
MTUU: HKBT2_3573
MBB: BCG_3448c
MBT: JTY_3448
MBX: BCGT_3252
MAF: MAF_33920
MMIC: RN08_3725
 » show all
Taxonomy
Reference
1  [PMID:15719101]
  Authors
Nakano C, Okamura T, Sato T, Dairi T, Hoshino T.
  Title
Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton.
  Journal
Chem Commun (Camb) 1016-8 (2005)
DOI:10.1039/b415346d
  Sequence
[mtu:Rv3377c]
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.16
IUBMB Enzyme Nomenclature: 5.5.1.16
ExPASy - ENZYME nomenclature database: 5.5.1.16
BRENDA, the Enzyme Database: 5.5.1.16

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