KEGG   ENZYME: 5.5.1.19Help
Entry
EC 5.5.1.19                 Enzyme                                 

Name
lycopene beta-cyclase;
CrtL;
CrtL-b;
CrtY;
LCYb;
carotenoid beta-end group lyase (decyclizing)
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
carotenoid beta-end group lyase (ring-opening)
Reaction(IUBMB)
carotenoid psi-end group = carotenoid beta-end group
Reaction(KEGG)
Substrate
carotenoid psi-end group
Product
carotenoid beta-end group [CPD:C21915]
Comment
The enzyme is a non-redox flavoprotein, containing FADH2 that is used for stabilization of a transition state. Lycopene has a psi-end group at both ends. When acting on one end, the enzyme forms gamma-carotene. When acting on both ends it forms beta-carotene. It also acts on neurosporene to give beta-zeacarotene.
History
EC 5.5.1.19 created 2011
Pathway
ec00906  Carotenoid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K06443  lycopene beta-cyclase
K14605  lycopene cyclase CruA
K14606  lycopene cyclase CruP
K17841  15-cis-phytoene synthase / lycopene beta-cyclase
K22502  lycopene beta-cyclase
Genes
RSS: 109442619
API: 100159332 100161104 100571777 100574964
DNX: 107165434 107165441 107165442 107165443 107165458
TUT: 107364280 107365901
ATH: AT3G10230(LYC)
ALY: ARALYDRAFT_478348
CRB: 17891714
CSAT: 104745202 104760303 104764729
EUS: EUTSA_v10020573mg
BRP: 103870482
BOE: 106295141
CPAP: 110822614
CIT: 102578042
TCC: 18598805
GRA: 105783300
DZI: 111297247
EGR: 104444307
VAR: 108329637
CCAJ: 109815644
CAM: 101508316
LJA: Lj0g3v0231639.1(Lj0g3v0231639.1)
ADU: 107492682
AIP: 107645549
LANG: 109358646
FVE: 101295928
PPER: 18771811
PMUM: 103339232
PAVI: 110770275
PXB: 103933980
CSV: 101207778
CMO: 103497264(LBCY)
MCHA: 111021308
RCU: 8286646
JCU: 105645080
HBR: 110664739
JRE: 108988394
VVI: 100252133(LBCY2)
SLY: 101267662 544104(LCY1)
CANN: 107843894 107869983(LCY1)
NTA: 107763207(CrtL-1) 107809095
NSY: 104240314
NTO: 104108950
INI: 109162118
SIND: 105159883
OEU: 111370424
HAN: 110878757
LSV: 111904093
DCR: 108193045
BVG: 104889451
SOE: 110797905
NNU: 104608835
OSA: 4328572
DOSA: Os02t0190600-00(Os02g0190600)
OBR: 102712228
BDI: 104583450
ATS: 109754598(LOC109754598)
SBI: 8077659
ZMA: 100383002
SITA: 101763950
PDA: 103722475
EGU: 105060532
MUS: 103998368
DCT: 110095206
AOF: 109824674
ATR: 18429822
MNG: MNEG_8175
CVR: CHLNCDRAFT_30425(LCYB)
APRO: F751_1786
NCR: NCU00585(al-2)
NTE: NEUTE1DRAFT53791(NEUTE1DRAFT_53791)
SMP: SMAC_01277(putative al2)
MBE: MBM_00659
TVE: TRV_03236
PTE: PTT_09938
ESA: ESA_00344
CSK: ES15_0619(crtY)
CTU: CTU_35420(crtY)
LEI: C2U54_12115(crtY)
LEH: C3F35_04360(crtY)
PSTS: E05_04210
EGE: EM595_0219(crtY)
PAM: PANA_4160(crtY)
PLF: PANA5342_p10301(crtY)
PAJ: PAJ_p0124(crtY)
PAQ: PAGR_p227
PVA: Pvag_pPag30173(crtY)
PAGG: AL522_02520(crtY)
PSTW: DSJ_25970
PGZ: C2E15_03085(crtY)
PCD: C2E16_03190(crtY)
PLU: plu4341(crtY)
LUM: CNR27_10985(crtY)
PSA: PST_3874
PSTT: CH92_19215
ACX: Achr_15290(crtY)
GNI: GNIT_0398(lcyB)
GPS: C427_1921(lcyB)
LHA: LHA_1129
PLE: B186_261(crtY)
PLY: C530_251
PLR: PAQ_256(crtY)
PLO: C548_251
PLD: PalTV_231(crtY)
PLB: PTV_231(crtY)
PLC: PAD_239(crtY)
PLI: PLF_238(crtY)
PALY: O3E_01515
SALN: SALB1_1270
RTA: Rta_07720
MELM: C7H73_12395(crtY)
MASZ: C9I28_27260(crtY)
MTIM: DIR46_08610(crtY)
MASY: DPH57_22000(crtY)
SSDC: SSDC_01989(crtY)
HOH: Hoch_2209
BBA: Bd1730
BRA: BRADO6508(crtY)
XAU: Xaut_3576
RVA: Rvan_0149
CAK: Caul_1713
CMB: CSW64_08145(crtY)
BVC: CEP68_00755(crtY)
PYE: A6J80_22070(crtY)
NAR: Saro_1817
NOV: TQ38_003990(crtY)
SAL: Sala_3135
SPHP: LH20_01370
SMAZ: LH19_18595
SPHU: SPPYR_3142(crtY)
SWI: Swit_3200
SPHD: HY78_09555
SPHM: G432_07835
STAX: MC45_14765
SPHI: TS85_20450
SSAN: NX02_00965
SPKC: KC8_11305
SPHC: CVN68_16205(crtY)
SJP: SJA_C1-01610(crtY)
SSY: SLG_31720(crtY)
SPMI: K663_01395
SPHB: EP837_01645(lcyB)
SPHR: BSY17_1788(crtY)
SINB: SIDU_17130
SPHT: K426_20400
SHYD: CJD35_07280(crtY)
SYA: A6768_23665(crtY)
SPHY: CHN51_13375(crtY)
BLAS: BSY18_2317(crtY)
RDI: CMV14_00555(crtY)
ELI: ELI_09880
EFV: CHH26_13515(crtY)
ERK: CD351_14880(crtY)
ERR: DVR09_04945(crtY)
AAY: WYH_03020
PHZ: CHX26_05585(crtY)
PUB: SAR11_0122(crtY)
AAD: TC41_3168
MVA: Mvan_5914
MGI: Mflv_0950
MVQ: MYVA_5869(crtL)
ASD: AS9A_1909(crtL)
CUR: cu1013
CRD: CRES_1060(crtL)
CVA: CVAR_1461
CTER: A606_05690
COA: DR71_19
CAQU: CAQU_06595
NFA: NFA_34900(crtL2)
NFR: ERS450000_00558(crtL_1) ERS450000_03396(crtL_2)
RER: RER_30640(crtL)
REY: O5Y_14040
ROP: ROP_69910(crtL)
REQ: REQ_22360
RHB: NY08_1078
RFA: A3L23_04326(crtL)
RHS: A3Q41_03941(crtL)
RHU: A3Q40_01667(crtL)
RRT: 4535765_02241(crtL)
GBR: Gbro_2394
GOR: KTR9_2309
TPR: Tpau_2495
SCO: SCO0191(crtY)
SMA: SAVERM_1021(crtY)
SGR: SGR_54t(crtY2) SGR_6824(crtY) SGR_7085t(crtY3)
SCB: SCAB_5491(crtY)
SCT: SCAT_p0246(crtY)
SFA: Sfla_0350
SHY: SHJG_1676
SALB: XNR_5692
SALS: SLNWT_1106
STRP: F750_6661
SFI: SFUL_37
STRM: M444_00680
SPRI: SPRI_1989
SLE: sle_65910(sle_65910)
SLAU: SLA_5752
IDO: I598_1140(crtL)
SERJ: SGUI_1797
DCO: SAMEA4475696_0723(crtL)
TFU: Tfu_3088
NDA: Ndas_3568
NAL: B005_0704
KRA: Krad_0091
SEN: SACE_2184
AOI: AORI_2833(lcyB)
PSEA: WY02_03220
PSEE: FRP1_09575
PSEH: XF36_11050
AMI: Amir_5144
SESP: BN6_56360(crtY) BN6_62220(crtL)
KAL: KALB_3743
ACTI: UA75_12655
ACAD: UA74_12575
AHG: AHOG_11845(crtL)
ALL: CRK56378
SAQ: Sare_2557
MIL: ML5_5108
RXY: Rxyl_2038
AYM: YM304_23780(crtL)
SYY: SYNGTS_1984(sll0147) SYNGTS_2802(sll0659)
SYT: SYNGTI_1983(sll0147) SYNGTI_2801(sll0659)
SYS: SYNPCCN_1982(sll0147) SYNPCCN_2800(sll0659)
SYQ: SYNPCCP_1982(sll0147) SYNPCCP_2800(sll0659)
SYW: SYNW0728(crtL)
SYC: syc0876_d syc2031_d(crtL)
SYG: sync_0974
SYR: SynRCC307_0743(crtL)
SYX: SynWH7803_1588(crtL)
SYNR: KR49_04885
SYND: KR52_06575
SYH: Syncc8109_2036(crtL)
SYNW: SynWH8103_00830(crtL-b)
TEL: tlr1139
THN: NK55_02970(cruA)
CYI: CBM981_1236(crtL)
PMA: Pro_1136(lcyB)
PMM: PMM1064(crtL1)
PMT: PMT_1123
PRC: EW14_1203
PRM: EW15_1582
AMR: AM1_2386(cruP) AM1_5425(cruA) AM1_6075(crtL)
MPK: VL20_6410
CYL: AA637_01080(cruA) AA637_11195(cruP)
ARP: NIES39_A06350(cruA) NIES39_K00660(cruP)
GLJ: GKIL_3349(cruP) GKIL_3517(cruA)
NSP: BMF81_02823(cruA)
CEO: ETSB_0653
CAU: Caur_1819
CAG: Cagg_1563
HAU: Haur_3909
ATM: ANT_14930
CAP: CLDAP_21410(crtL)
DGO: DGo_CA2369(crtL) DGo_CA2876(cruF)
TRA: Trad_2428
TTH: TT_P0060
TTJ: TTHB104
TAQ: TO73_1252
IPA: Isop_3503
SRU: SRU_1501(crtY)
SRM: SRM_01699
RMR: Rmar_1608
CPI: Cpin_4955
SLI: Slin_0447
FAE: FAES_4443(crtY)
PSEZ: HME7025_01013(lcyB)
HSW: Hsw_0139
GFO: GFO_2502(crtY)
GFL: GRFL_0485
FJO: Fjoh_0926
FPS: FP1447(crtY)
FBR: FBFL15_2138(crtY)
FIN: KQS_13045(crtY)
ZPR: ZPR_0873
MARM: YQ22_09455
CBAL: M667_06290
CBAT: M666_06235
DOK: MED134_08681(crtY)
DDO: I597_0502
ZGA: ZOBELLIA_1952(crtY)
MLT: VC82_1583
NDO: DDD_2392(crtY)
POM: MED152_02660(crtY)
WIN: WPG_0049
SPON: HME9304_01749(lcyB)
CTE: CT0456
CPC: Cpar_0452
CCH: Cag_0265
CLI: Clim_2017
PVI: Cvib_1484
PLT: Plut_1700
PPH: Ppha_0482
PAA: Paes_0426
CTS: Ctha_0083
HAL: VNG_2137G(ggt)
HSL: OE_3983R(crtY)
HHB: Hhub_3439(crtY)
HMA: rrnAC2067(crtY)
HHI: HAH_2562(crtY)
NPH: NP_0652A(crtY)
NMO: Nmlp_1293(crtY)
HUT: Huta_0316
HTI: HTIA_0509
HMU: Hmuk_1284
HWA: HQ_1018A(crtY)
HWC: Hqrw_1020(crtY)
HLA: Hlac_2731
NAT: NJ7G_2815
 » show all
Taxonomy
Reference
1  [PMID:8344419]
  Authors
Cunningham FX Jr, Chamovitz D, Misawa N, Gantt E, Hirschberg J
  Title
Cloning and functional expression in Escherichia coli of a cyanobacterial gene for lycopene cyclase, the enzyme that catalyzes the biosynthesis of beta-carotene.
  Journal
FEBS Lett 328:130-8 (1993)
DOI:10.1016/0014-5793(93)80980-9
Reference
2  [PMID:7919981]
  Authors
Cunningham FX Jr, Sun Z, Chamovitz D, Hirschberg J, Gantt E
  Title
Molecular structure and enzymatic function of lycopene cyclase from the cyanobacterium Synechococcus sp strain PCC7942.
  Journal
Plant Cell 6:1107-21 (1994)
DOI:10.1105/tpc.6.8.1107
  Sequence
Reference
3  [PMID:7550379]
  Authors
Hugueney P, Badillo A, Chen HC, Klein A, Hirschberg J, Camara B, Kuntz M
  Title
Metabolism of cyclic carotenoids: a model for the alteration of this biosynthetic pathway in Capsicum annuum chromoplasts.
  Journal
Plant J 8:417-24 (1995)
DOI:10.1046/j.1365-313X.1995.08030417.x
  Sequence
Reference
4  [PMID:8624411]
  Authors
Pecker I, Gabbay R, Cunningham FX Jr, Hirschberg J
  Title
Cloning and characterization of the cDNA for lycopene beta-cyclase from tomato reveals decrease in its expression during fruit ripening.
  Journal
Plant Mol Biol 30:807-19 (1996)
  Sequence
[sly:544104] [ag:CAA57386]
Reference
5  [PMID:11943208]
  Authors
Hornero-Mendez D, Britton G
  Title
Involvement of NADPH in the cyclization reaction of carotenoid biosynthesis.
  Journal
FEBS Lett 515:133-6 (2002)
DOI:10.1016/S0014-5793(02)02453-5
Reference
6  [PMID:17606904]
  Authors
Maresca JA, Graham JE, Wu M, Eisen JA, Bryant DA.
  Title
Identification of a fourth family of lycopene cyclases in photosynthetic bacteria.
  Journal
Proc Natl Acad Sci U S A 104:11784-9 (2007)
DOI:10.1073/pnas.0702984104
  Sequence
Reference
7  [PMID:20178989]
  Authors
Yu Q, Schaub P, Ghisla S, Al-Babili S, Krieger-Liszkay A, Beyer P
  Title
The lycopene cyclase CrtY from Pantoea ananatis (formerly Erwinia uredovora) catalyzes an FADred-dependent non-redox reaction.
  Journal
J Biol Chem 285:12109-20 (2010)
DOI:10.1074/jbc.M109.091843
Other DBs
ExplorEnz - The Enzyme Database: 5.5.1.19
IUBMB Enzyme Nomenclature: 5.5.1.19
ExPASy - ENZYME nomenclature database: 5.5.1.19
BRENDA, the Enzyme Database: 5.5.1.19
CAS: 220801-82-1

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