KEGG   ENZYME: 6.2.1.13Help
Entry
EC 6.2.1.13                 Enzyme                                 

Name
acetate---CoA ligase (ADP-forming);
acetyl-CoA synthetase (ADP-forming);
acetyl coenzyme A synthetase (adenosine diphosphate-forming);
acetate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
acetate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + acetate + CoA = ADP + phosphate + acetyl-CoA [RN:R00229]
Reaction(KEGG)
R00229;
(other) R00920
Show
Substrate
ATP [CPD:C00002];
acetate [CPD:C00033];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
acetyl-CoA [CPD:C00024]
Comment
Also acts on propanoate and, very slowly, on butanoate.
History
EC 6.2.1.13 created 1978
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec00620  Pyruvate metabolism
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K01905  acetate---CoA ligase (ADP-forming) subunit alpha
K22224  acetate---CoA ligase (ADP-forming) subunit beta
Genes
PBA: PSEBR_a2049
PSYG: AK825_07060
MBS: MRBBS_1009
MPQ: ABA45_05225
HAM: HALO2742
HCO: LOKO_03041
HALO: BWR19_06730
HHH: CLM76_16155
HBE: BEI_1078
HAG: BB497_11395
BPAR: BN117_0625
AMIM: MIM_c20900
TCL: Tchl_1444
DMA: DMR_20040
DBA: Dbac_2428
DPS: DP0658
DSF: UWK_02600
DOL: Dole_3063
DAL: Dalk_1024
DAT: HRM2_06780(sucD1) HRM2_16770(sucD3)
SFU: Sfum_1966
RBM: TEF_03555
CID: P73_4460
MALG: MALG_03806
MGM: Mmc1_1098
SIV: SSIL_1754
CBK: CLL_A1114
CBT: CLH_1050
CSQ: CSCA_2386
RTO: RTO_07190
DAU: Daud_0895
CHY: CHY_0264
ADG: Adeg_1700
TACI: TDSAC_1401
MHAD: B586_00710
RCA: Rcas_0076
CAU: Caur_3920
CAG: Cagg_3834
HAU: Haur_3750
KST: KSMBR1_0955(pauA_2) KSMBR1_2202(acs) KSMBR1_3045(acdB)
TLI: Tlie_0183
IAL: IALB_2623
MRO: MROS_1085
CABY: Cabys_1346
BANA: BARAN1_1157(acdA)
TMG: US01_C0001G0461(acdAB)
MJA: MJ_0590
MMP: MMP0253(acd)
MMD: GYY_01290
MAE: Maeo_0034
MVO: Mvol_1194
MST: Msp_0919
MSI: Msm_1471
MRU: mru_1570(acs)
MEB: Abm4_1186(acs)
MMIL: sm9_1596(acs)
MEYE: TL18_07040
MOL: YLM1_1056
METH: MBMB1_1225
MFC: BRM9_0434(acs)
MCUB: MCBB_0936
MFV: Mfer_1000
MKA: MK1246
AFU: AF_1211
TAC: Ta1153
TVO: TVG1294312(TVG1294312)
MARC: AR505_1282
PHO: PH0766(PH0766) PH1517(PH1517) PH1739(PH1739) PH1788(PH1788)
PAB: PAB0203(sucC-like) PAB0854 PAB1937 PAB2113
TGA: TGAM_0426(acdA-3) TGAM_0742(acdB-1) TGAM_1201(acdA-5) TGAM_1288(acdB-2)
MAC: MA_3168(acdA) MA_3602(acdB)
MBU: Mbur_1347
MMET: MCMEM_1839
MMH: Mmah_1654
MPY: Mpsy_1182
MPD: MCP_0448(acdB) MCP_0449(acdA) MCP_2918
MEZ: Mtc_0315(acdAB) Mtc_1390(acdB) Mtc_1391(acdA)
RCI: RCIX1773(acdB) RCIX1774(acdA) RCIX831(acdAB)
HAL: VNG_0940G(acs3)
HSL: OE_2372F(acdA)
HHB: Hhub_2126(acdA1) Hhub_2435(acdB)
HALH: HTSR_0956
HHSR: HSR6_0987
HMA: rrnAC0888(scs)
HHI: HAH_1525(scs)
NPH: NP_2858A(acdA)
NMO: Nmlp_2817(acdA)
HUT: Huta_2278
HTI: HTIA_1968
HMU: Hmuk_2291
HVO: HVO_1000(acdA)
HME: HFX_0998
HLA: Hlac_0317
HTU: Htur_1637
NMG: Nmag_3477(acdA)
NAT: NJ7G_3477
SALI: L593_12905
PAI: PAE3249
PIS: Pisl_0485
PCL: Pcal_1855
PAS: Pars_1805
PYR: P186_1420
POG: Pogu_0325
TNE: Tneu_1634
CMA: Cmaq_1092
TUZ: TUZN_1460
TTN: TTX_2015(acd)
VDI: Vdis_2379
VMO: VMUT_0727
ACIA: SE86_07220
NAA: Nps_01715
MARH: Mia14_0928
BARC: AOA65_0921
 » show all
Taxonomy
Reference
1  [PMID:13076]
  Authors
Reeves RE, Warren LG, Susskind B, Lo HS.
  Title
An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase.
  Journal
J Biol Chem 252:726-31 (1977)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.13
IUBMB Enzyme Nomenclature: 6.2.1.13
ExPASy - ENZYME nomenclature database: 6.2.1.13
BRENDA, the Enzyme Database: 6.2.1.13
CAS: 62009-85-2

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