KEGG   ENZYME: 6.2.1.14Help
Entry
EC 6.2.1.14                 Enzyme                                 

Name
6-carboxyhexanoate---CoA ligase;
6-carboxyhexanoyl-CoA synthetase;
pimelyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
6-carboxyhexanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate + 6-carboxyhexanoyl-CoA [RN:R03209]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
6-carboxyhexanoate [CPD:C02656];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
6-carboxyhexanoyl-CoA [CPD:C01063]
History
EC 6.2.1.14 created 1983
Pathway
ec00780  Biotin metabolism
ec01100  Metabolic pathways
Orthology
K01906  6-carboxyhexanoate--CoA ligase
Genes
PCA: Pcar_1666(bioW)
PACE: A6070_06910
PEF: A7E78_02755
DES: DSOUD_1422
DEU: DBW_2418(bioW)
DDS: Ddes_0424
DFI: AXF13_07405
BSU: BSU30240(bioW)
BSR: I33_3078(bioW)
BSL: A7A1_1652
BSH: BSU6051_30240(bioW)
BSUT: BSUB_03213(bioW)
BSUL: BSUA_03213(bioW)
BSUS: Q433_16400
BSS: BSUW23_14650(bioW)
BST: GYO_3272(bioW)
BSQ: B657_30240(bioW)
BSX: C663_2869(bioW)
BLI: BL02411(bioW)
BLD: BLi00766(bioW)
BLH: BaLi_c08640(bioW)
BAY: RBAM_018290(bioW)
BYA: BANAU_1954(bioW)
BAMP: B938_09460
BAML: BAM5036_1766(bioW)
BAMA: RBAU_1804(bioW)
BAMN: BASU_1784(bioW)
BAMB: BAPNAU_1915(bioW)
BAMT: AJ82_10390
BAMY: V529_17990(bioW)
BMP: NG74_01905(bioW)
BAO: BAMF_1924(bioW)
BAZ: BAMTA208_07885(bioW)
BQL: LL3_02014(bioW)
BXH: BAXH7_01606(bioW)
BQY: MUS_2183(bioW)
BAMI: KSO_010220
BAMC: U471_18840
BAMF: U722_09675
BPF: BpOF4_16065(bioW)
BJS: MY9_3024
BACP: SB24_00510
BACB: OY17_12280
BACO: OXB_3347
BACY: QF06_13310
BACL: BS34A_32880(bioW)
BALM: BsLM_3008
BEO: BEH_11230
BGY: BGLY_0780
BKW: BkAM31D_02740(bioW)
VPN: A21D_01033(bioW)
SAU: SA2211
SAV: SAV2423
SAW: SAHV_2407
SAM: MW2346
SAS: SAS2314
SAR: SAR2513
SAC: SACOL2424(bioW)
SAX: USA300HOU_2407(bioW)
SAE: NWMN_2322(bioW)
SAD: SAAV_2489(bioW)
SUJ: SAA6159_02324(bioW)
SUZ: MS7_2438
SUG: SAPIG2476
SAUA: SAAG_00250
SAUE: RSAU_002262(bioW)
SAUS: SA40_2173
SAUU: SA957_2257
SAUG: SA268_2330
SAUT: SAI1T1_2017980(bioW)
SAUJ: SAI2T2_1017990(bioW)
SAUK: SAI3T3_1017980(bioW)
SAUQ: SAI4T8_1017990(bioW)
SAUV: SAI7S6_1017980(bioW)
SAUW: SAI5S5_1017920(bioW)
SAUX: SAI6T6_1017920(bioW)
SAUY: SAI8T7_1017960(bioW)
SAUF: X998_2409
SAB: SAB2304c
SAUB: C248_2471
SAUC: CA347_2503
SAUR: SABB_02993(bioW)
SAUI: AZ30_12740
SAUD: CH52_06865
SAMS: NI36_12020
SEP: SE0182
SER: SERP2393(bioW)
SEPP: SEB_00113
SEPS: DP17_1279
SDT: SPSE_0126(bioW)
SHU: SHYC_01065(bioW)
SSCH: LH95_00995
SSCZ: RN70_01215
SAGQ: EP23_09060
ASOC: CB4_02730(bioW)
CACE: CACET_c13450(bioW)
RTO: RTO_04560
CTHM: CFE_1510
TKI: TKV_c07350(bioW)
CAD: Curi_c25540(bioW)
VPR: Vpar_1006
VRM: 44547418_01018(bioW)
SRI: SELR_03060(bioWF)
MHG: MHY_24740
PUF: UFO1_4053
CDI: DIP1381
CDIP: ERS451417_01397(bioW)
CKP: ckrop_1506(bioWF)
CPU: cpfrc_01183(bioW)
CPL: Cp3995_1206(bioW)
CPG: Cp316_1229(bioW)
CPP: CpP54B96_1201(bioW)
CPK: Cp1002_1179(bioW)
CPQ: CpC231_1178(bioW)
CPX: CpI19_1185(bioW)
CPZ: CpPAT10_1177(bioW)
COR: Cp267_1234(bioW)
COP: Cp31_1191(bioW)
COD: Cp106_1161(bioW)
COS: Cp4202_1171(bioW)
COI: CpCIP5297_1200(bioW)
COE: Cp258_1198(bioW)
COU: Cp162_1177(bioW)
CPSE: CPTA_01755
CPSU: CPTB_02008
CPSF: CPTC_01746
CUL: CULC22_01291(bioW)
CUC: CULC809_01277(bioW)
CUE: CULC0102_1406(bioW)
CUN: Cul210932_1345(bioW)
CUS: CulFRC11_1258(bioW)
CUQ: Cul210931_1242(bioW)
CUZ: Cul05146_1318(bioW)
CUJ: CUL131002_1273(bioW)
COA: DR71_1458(bioF)
CSP: WM42_2495
CMIN: NCTC10288_01030(bioW)
PAC: PPA1866
PAW: PAZ_c19410(bioF)
PACC: PAC1_09540
PACH: PAGK_1785
CACN: RN83_09625
CGRN: 4412665_00276(bioW)
TPI: TREPR_3053(bioW)
FSC: FSU_0221(bioW)
AAE: aq_1659(bioW)
HTH: HTH_1774(bioW)
TAL: Thal_1538
SAF: SULAZ_1395(bioW)
PMX: PERMA_1854(bioW)
TYE: THEYE_A0810(bioW)
LFC: LFE_0971
LFI: LFML04_1509(bioW)
MJA: MJ_1297
MMP: MMP1575(bioW)
MMD: GYY_08730
MAE: Maeo_1420
MVO: Mvol_1143
MRU: mru_2041(bioW)
MOL: YLM1_1481
 » show all
Taxonomy
Reference
1  [PMID:4623286]
  Authors
Izumi Y, Morita H, Sato K, Tani Y, Ogata K.
  Title
Synthesis of biotin-vitamers from pimelic acid and coenzyme A by cell-free extracts of various bacteria.
  Journal
Biochim Biophys Acta 264:210-3 (1972)
DOI:10.1016/0304-4165(72)90133-X
Reference
2
  Authors
Izumi, Y., Morita, H., Tani, Y. and Ogata, K.
  Title
The pimelyl-CoA synthetase responsible for the first step in biotin biosynthesis by microorganisms.
  Journal
Agric Biol Chem 38:2257-2262 (1974)
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.14
IUBMB Enzyme Nomenclature: 6.2.1.14
ExPASy - ENZYME nomenclature database: 6.2.1.14
BRENDA, the Enzyme Database: 6.2.1.14
CAS: 55467-50-0

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