KEGG   ENZYME: 6.2.1.27Help
Entry
EC 6.2.1.27                 Enzyme                                 

Name
4-hydroxybenzoate---CoA ligase;
4-hydroxybenzoate-CoA synthetase;
4-hydroxybenzoate---coenzyme A ligase (AMP-forming);
4-hydroxybenzoyl coenzyme A synthetase;
4-hydroxybenzoyl-CoA ligase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-hydroxybenzoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA [RN:R01300]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-hydroxybenzoate [CPD:C00156];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-hydroxybenzoyl-CoA [CPD:C02949]
History
EC 6.2.1.27 created 1992
Pathway
ec00362  Benzoate degradation
ec00627  Aminobenzoate degradation
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K04105  4-hydroxybenzoate-CoA ligase
K20458  3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase
Genes
EBA: ebA727(hbcL)
AZI: AzCIB_4612
TCL: Tchl_2972
TAK: Tharo_1872
BJA: blr1077
BJU: BJ6T_11070
BJP: RN69_05405
BRA: BRADO6791
BBT: BBta_0747
BRS: S23_67390
AOL: S58_06690
RPA: RPA0669(hbaA)
RPB: RPB_4656
RPC: RPC_1016
RPE: RPE_0592
RPT: Rpal_0736
SIL: SPO3697(badA-1)
JAN: Jann_0669
MAGX: XM1_2792(bclA) XM1_3957(hcl)
MAGN: WV31_08755
 » show all
Taxonomy
Reference
1  [PMID:2914844]
  Authors
Merkel SM, Eberhard AE, Gibson J, Harwood CS.
  Title
Involvement of coenzyme A thioesters in anaerobic metabolism of 4-hydroxybenzoate by Rhodopseudomonas palustris.
  Journal
J Bacteriol 171:1-7 (1989)
DOI:10.1128/JB.171.1.1-7.1989
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.27
IUBMB Enzyme Nomenclature: 6.2.1.27
ExPASy - ENZYME nomenclature database: 6.2.1.27
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.27
BRENDA, the Enzyme Database: 6.2.1.27
CAS: 119699-80-8

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