KEGG   ENZYME: 6.3.2.41Help
Entry
EC 6.3.2.41                 Enzyme                                 

Name
N-acetylaspartylglutamate synthase;
N-acetylaspartylglutamate synthetase;
NAAG synthetase;
NAAGS;
RIMKLA (gene name) (ambiguous);
RIMKLB (gene name) (ambiguous)
Class
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
BRITE hierarchy
Sysname
N-acetyl-L-aspartate:L-glutamate ligase (ADP, N-acetyl-L-aspartyl-L-glutamate-forming)
Reaction(IUBMB)
ATP + N-acetyl-L-aspartate + L-glutamate = ADP + phosphate + N-acetyl-L-aspartyl-L-glutamate [RN:R10678]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
N-acetyl-L-aspartate [CPD:C01042];
L-glutamate [CPD:C00025]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
N-acetyl-L-aspartyl-L-glutamate [CPD:C12270]
Comment
The enzyme, found in animals, produces the neurotransmitter N-acetyl-L-aspartyl-L-glutamate. One isoform also has the activity of EC 6.3.1.17, beta-citrylglutamate synthase [2], while another isoform has the activity of EC 6.3.2.42, N-acetylaspartylglutamylglutamate synthase [3].
History
EC 6.3.2.41 created 2014
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec01100  Metabolic pathways
Orthology
K18310  beta-citrylglutamate/N-acetylaspartylglutamate synthase
K18311  N-acetylaspartylglutamate/N-acetylaspartylglutamylglutamate synthase
Genes
HSA: 284716(RIMKLA) 57494(RIMKLB)
PTR: 735860(RIMKLB) 748944(RIMKLA)
PPS: 100970527(RIMKLA) 100974820(RIMKLB)
GGO: 101136567(RIMKLB) 101137769(RIMKLA)
PON: 100441104(RIMKLB) 100457877(RIMKLA)
NLE: 100589997(RIMKLA) 100593570(RIMKLB)
MCC: 699767(RIMKLA) 722261(RIMKLB)
MCF: 102124154(RIMKLB) 102128755(RIMKLA)
CSAB: 103218536(RIMKLB) 103225007(RIMKLA)
RRO: 104668996(RIMKLA) 104672842(RIMKLB)
RBB: 108530380(RIMKLA) 108543684(RIMKLB)
CJC: 100400904(RIMKLA) 100406491(RIMKLB)
SBQ: 101028223(RIMKLA) 101033047(RIMKLB)
MMU: 108653(Rimklb) 194237(Rimkla)
RNO: 362428(Rimklb)
CGE: 100759423(Rimkla) 100760031(Rimklb)
NGI: 103727467(Rimklb) 103735994(Rimkla)
HGL: 101706744(Rimklb) 101721728(Rimkla)
CCAN: 109697724(Rimklb) 109702396(Rimkla)
OCU: 100346793(RIMKLB) 100356205(RIMKLA)
TUP: 102472940(RIMKLB) 102474653(RIMKLA)
CFA: 482445(RIMKLA) 486698(RIMKLB)
AML: 100472546(RIMKLA) 100473320(RIMKLB)
UMR: 103669163(RIMKLB) 103670923(RIMKLA)
ORO: 101368732(RIMKLA) 101374535(RIMKLB)
FCA: 101097740(RIMKLB) 101099388(RIMKLA)
PTG: 102959348(RIMKLA) 102963865(RIMKLB)
AJU: 106965320(RIMKLB) 106970196(RIMKLA)
BTA: 507323(RIMKLA) 538579(RIMKLB)
BOM: 102269649(RIMKLB) 102285876(RIMKLA)
BIU: 109556903(RIMKLA) 109559695(RIMKLB)
PHD: 102321435(RIMKLB) 102329993(RIMKLA)
CHX: 102176861(RIMKLB) 102179728(RIMKLA)
OAS: 101102554(RIMKLB) 101104941(RIMKLA)
SSC: 100152915(RIMKLB) 100522878(RIMKLA)
CFR: 102503881(RIMKLB) 102522941(RIMKLA)
CDK: 105098170(RIMKLB) 105105491(RIMKLA)
BACU: 103018606(RIMKLA) 103019013(RIMKLB)
LVE: 103069710(RIMKLB) 103083571(RIMKLA)
OOR: 101273054(RIMKLB) 101275823(RIMKLA)
ECB: 100061350(RIMKLB) 100067475(RIMKLA)
EPZ: 103557317(RIMKLA) 103564581(RIMKLB)
EAI: 106837431(RIMKLB) 106847814(RIMKLA)
MYB: 102245342(RIMKLB) 102249129(RIMKLA)
MYD: 102752373(RIMKLB) 102754710(RIMKLA)
HAI: 109372752(RIMKLB) 109383339(RIMKLA)
RSS: 109435559(RIMKLB) 109457900(RIMKLA)
PALE: 102880426(RIMKLB) 102882758(RIMKLA)
LAV: 100657534(RIMKLB) 100664484(RIMKLA)
MDO: 100013787(RIMKLB) 100026482(RIMKLA)
SHR: 100913508(RIMKLA) 100930894(RIMKLB)
OAA: 100073839(RIMKLA) 100080568(RIMKLB) 100090307
GGA: 418255(RIMKLB)
MGP: 104916636
CJO: 107318392(RIMKLB)
APLA: 101792875(RIMKLB)
ACYG: 106048091(RIMKLB)
TGU: 100220208(RIMKLB)
GFR: 102035986(RIMKLB)
FAB: 101814507(RIMKLB)
PHI: 102111957(RIMKLB)
PMAJ: 107210434(RIMKLB)
CCAE: 111925810(RIMKLB)
CCW: 104690266(RIMKLB)
FPG: 101913481(RIMKLB)
FCH: 102056126(RIMKLB)
CLV: 102098362(RIMKLB)
EGZ: 104122771(RIMKLB)
AAM: 106495722(RIMKLB)
ASN: 102373845(RIMKLB)
AMJ: 102576775(RIMKLB)
PSS: 102451018(RIMKLB)
CMY: 102933090(RIMKLB)
CPIC: 101943668(RIMKLB)
ACS: 100563778(rimklb)
PVT: 110069781(RIMKLB)
PBI: 103055545(RIMKLB)
GJA: 107117747(RIMKLB)
XTR: 100145548(rimkla) 100486701(rimklb)
NPR: 108783941(RIMKLA) 108799485(RIMKLB)
DRE: 447815(rimkla)
SANH: 107669631
IPU: 108265850(rimkla)
AMEX: 103035057
TRU: 101062827
LCO: 104920219(rimkla)
NCC: 104955181(rimkla)
MZE: 101477475
OLA: 101169452(rimklb)
XMA: 102218635
PRET: 103467997(rimkla)
NFU: 107390714
KMR: 108236831
CSEM: 103384935
LCF: 108891717(rimkla)
SDU: 111219047
BPEC: 110161111
MALB: 109970719
ELS: 105013808
LCM: 102351441(RIMKLB) 102354509(RIMKLA)
CMK: 103190080(rimkla)
SALU: DC74_1330
SALL: SAZ_07145
STRE: GZL_07873
SLD: T261_0304
SRW: TUE45_pSRc_0607(rimK)
SNR: SNOUR_35955(rimKLB)
SALF: SMD44_08847(cofF)
SALJ: SMD11_0857
 » show all
Taxonomy
Reference
1  [PMID:20643647]
  Authors
Becker I, Lodder J, Gieselmann V, Eckhardt M
  Title
Molecular characterization of N-acetylaspartylglutamate synthetase.
  Journal
J Biol Chem 285:29156-64 (2010)
DOI:10.1074/jbc.M110.111765
  Sequence
[mmu:108653] [hsa:57494]
Reference
2  [PMID:20657015]
  Authors
Collard F, Stroobant V, Lamosa P, Kapanda CN, Lambert DM, Muccioli GG, Poupaert JH, Opperdoes F, Van Schaftingen E
  Title
Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.
  Journal
J Biol Chem 285:29826-33 (2010)
DOI:10.1074/jbc.M110.152629
  Sequence
Reference
3  [PMID:21454531]
  Authors
Lodder-Gadaczek J, Becker I, Gieselmann V, Wang-Eckhardt L, Eckhardt M
  Title
N-acetylaspartylglutamate synthetase II synthesizes N-acetylaspartylglutamylglutamate.
  Journal
J Biol Chem 286:16693-706 (2011)
DOI:10.1074/jbc.M111.230136
  Sequence
[mmu:194237] [hsa:284716]
Other DBs
ExplorEnz - The Enzyme Database: 6.3.2.41
IUBMB Enzyme Nomenclature: 6.3.2.41
ExPASy - ENZYME nomenclature database: 6.3.2.41
BRENDA, the Enzyme Database: 6.3.2.41

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