KEGG   ENZYME: 6.6.1.1Help
Entry
EC 6.6.1.1                  Enzyme                                 

Name
magnesium chelatase;
protoporphyrin IX magnesium-chelatase;
protoporphyrin IX Mg-chelatase;
magnesium-protoporphyrin IX chelatase;
magnesium-protoporphyrin chelatase;
magnesium-chelatase;
Mg-chelatase;
Mg-protoporphyrin IX magnesio-lyase
Class
Ligases;
Forming nitrogen-D-metal bonds;
Forming coordination complexes
BRITE hierarchy
Sysname
Mg-protoporphyrin IX magnesium-lyase
Reaction(IUBMB)
ATP + protoporphyrin IX + Mg2+ + H2O = ADP + phosphate + Mg-protoporphyrin IX + 2 H+ [RN:R03877]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
protoporphyrin IX [CPD:C02191];
Mg2+ [CPD:C00305];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
Mg-protoporphyrin IX [CPD:C03516];
H+ [CPD:C00080]
Comment
This is the first committed step of chlorophyll biosynthesis and is a branchpoint of two major routes in the tetrapyrrole pathway.
History
EC 6.6.1.1 created 2003
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K03403  magnesium chelatase subunit H
K03404  magnesium chelatase subunit D
K03405  magnesium chelatase subunit I
Genes
ATH: AT1G08520(ALB1) AT4G18480(CHLI1) AT5G13630(GUN5) AT5G45930(CHLI2)
ALY: ARALYDRAFT_311903 ARALYDRAFT_494386 ARALYDRAFT_909315 ARALYDRAFT_914833
CRB: 17877299 17878910 17882263 17898130
CSAT: 104709121 104718469 104723216 104724797 104735370 104739443 104755033 104766715 104769581 104771840 104773343
EUS: EUTSA_v10000878mg EUTSA_v10006894mg EUTSA_v10012443mg EUTSA_v10025291mg
BRP: 103853670 103856025 103856423 103860994 103871596
BNA: 106346325 106357789 106375607 106381688 106410621 106414583 106424974 106429936 106431009 106440180 106440918
BOE: 106294567 106305162 106306835 106326893 106334373
THJ: 104806148 104814243 104826486 104827316
CPAP: 110811210 110811876 110821939
LJA: Lj1g3v4251210.1(Lj1g3v4251210.1) Lj1g3v4251220.1(Lj1g3v4251220.1) Lj2g3v2089750.1(Lj2g3v2089750.1) Lj2g3v2089750.2(Lj2g3v2089750.2)
DOSA: Os03t0563300-01(Os03g0563300) Os03t0811100-01(Os03g0811100)
ATS: 109758055(LOC109758055) 109760656(LOC109760656) 109774815(LOC109774815)
SMIN: v1.2.011328.t1(symbB.v1.2.011328.t1) v1.2.011329.t1(symbB.v1.2.011329.t1) v1.2.020884.t1(symbB.v1.2.020884.t1) v1.2.020885.t1(symbB.v1.2.020885.t1) v1.2.038079.t1(symbB.v1.2.038079.t1)
NGD: NGA_0624200(CHLH2)
PAE: PA2942
PAEV: N297_3046
PAEI: N296_3046
PAEP: PA1S_10690
PAEM: U769_10230
PAEL: T223_10705
PAEG: AI22_23180
PAEC: M802_3043
PAEO: M801_2911
PMY: Pmen_4585
PMK: MDS_4925
PPSE: BN5_4396
PCQ: PcP3B5_08260(bchI)
PPU: PP_3506
PPF: Pput_2270
PPT: PPS_2577
PPX: T1E_1714(chlI)
PPUH: B479_12460
PPUT: L483_18390
PPUN: PP4_23340
PPUD: DW66_2836
PMON: X969_11945
PMOT: X970_11600
PSB: Psyr_3014
PSYR: N018_11480
PSP: PSPPH_2226(bchI)
PFL: PFL_3653(bchI)
PPRO: PPC_3794
PFS: PFLU_2671
PFE: PSF113_3254(chlI)
PFC: PflA506_2483(bchI)
PFW: PF1751_v1c23360(bchI)
PFB: VO64_5763
PMAN: OU5_0087
PEN: PSEEN2434
PPUU: PputUW4_02363(chlI)
PKC: PKB_0661
PSES: PSCI_4339
PSEM: TO66_19240
PSOS: POS17_3807
PSET: THL1_746
PSIL: PMA3_12270
ACX: Achr_f680
GAI: IMCC3135_08660(bchI)
HCH: HCH_06466(bchI)
HEL: HELO_1829(chlD)
HAM: HALO2048
EME: CEM_297(chlI)
GPB: HDN1F_26370(chII)
CVI: CV_1570
PSE: NH8B_1839(chlD)
RSO: RSp0625
RSN: RSPO_m00973(chlI)
RSE: F504_4600
BMAL: DM55_2989
BMAE: DM78_1455
BMAQ: DM76_2971
BMAI: DM57_54
BMAF: DM51_898
BMAZ: BM44_2190
BMAB: BM45_1754
BPS: BPSL1767
BPSE: BDL_291
BPSM: BBQ_1628
BPSU: BBN_1753
BPSD: BBX_2228
BPK: BBK_3253
BPSH: DR55_2865
BPSA: BBU_464
BPSO: X996_2482
BUT: X994_937
BTE: BTH_I2406
BTJ: BTJ_842
BTZ: BTL_2085
BTD: BTI_2049
BTV: BTHA_2284
BTHE: BTN_2683
BTHM: BTRA_2364
BTHA: DR62_2830
BTHL: BG87_2306
BOK: DM82_1285
BOC: BG90_3407
BVE: AK36_2244
BCN: Bcen_1178
BCJ: BCAL1712
BCEN: DM39_1624
BCEW: DM40_2290
BCEO: I35_1624
BAM: Bamb_1558
BMU: Bmul_1581
BMJ: BMULJ_01662(chlI)
BMK: DM80_3338
BMUL: NP80_1750
BCT: GEM_1756
BCED: DM42_38
BDL: AK34_1444
BCON: NL30_14795
BUB: BW23_68
BLAT: WK25_08155
BTEI: WS51_18830
BSEM: WJ12_08205
BPSL: WS57_26770
BMEC: WJ16_08305
BSTG: WT74_08555
BGU: KS03_2704
BGO: BM43_3266
BUK: MYA_1483
BUL: BW21_2114
BGP: BGL_1c18370(chlI)
BXE: Bxe_B1645
BXB: DR64_6953
BPH: Bphy_3151
BFN: OI25_4083
PLG: NCTC10937_02532(bchI)
DAC: Daci_5745
CTES: O987_11775
HSE: Hsero_2656(chlI)
HRB: Hrubri_2745(chlI)
RGE: RGE_16580(bchI) RGE_16590(bchD) RGE_33480(bchH) RGE_44510
METR: BSY238_2439(bchI) BSY238_2440(bchD) BSY238_2465(bchH)
BRA: BRADO1606(bchI) BRADO1607(bchD) BRADO1641(bchH)
BBT: BBta_6415(bchH) BBta_6448(bchD) BBta_6449(bchI)
BRS: S23_19040(bchI) S23_19050(bchD) S23_19400(bchH)
BRO: BRAD285_5760(bchH) BRAD285_5793(bchD) BRAD285_5794(bchI)
RPA: RPA1506(bchI) RPA1507(bchD) RPA1544(bchH)
BOS: BSY19_4026(bchH) BSY19_4065 BSY19_4066(bchI)
MEA: Mex_1p2470(bchI) Mex_1p3217(bchD) Mex_1p5271(bchH)
MDI: METDI3233(bchI) METDI3781(bchD) METDI5871(bchH)
MOR: MOC_2237(bchD) MOC_2239(bchI) MOC_2250(bchH)
META: Y590_11935 Y590_14600(bchD) Y590_24600(bchH)
RSP: RSP_0273(bchI) RSP_0274(bchD) RSP_0287(bchH)
RCP: RCAP_rcc00663(bchH) RCAP_rcc00676(bchD) RCAP_rcc00677(bchI)
JAN: Jann_0145(bchI) Jann_0146(bchD) Jann_0159(bchH)
RDE: RD1_0122(bchI) RD1_0123(bchD) RD1_0137(bchH)
DSH: Dshi_3502(bchI) Dshi_3503(bchD) Dshi_3536(bchH)
PTP: RCA23_c29520(bchD) RCA23_c29530(bchI) RCA23_c29900(bchH)
RSU: NHU_00213(bchH) NHU_00225(bchD) NHU_00226
BLAS: BSY18_2706(bchH) BSY18_3550(bchI) BSY18_3551(bchD)
AMV: ACMV_18880(bchD) ACMV_18890(bchI) ACMV_18980(bchH)
RRU: Rru_A0485 Rru_A0486(bchD) Rru_A0621(bchH)
RRF: F11_02490 F11_02495(bchD) F11_03185(bchH)
RCE: RC1_2081(bchI) RC1_2082(bchD) RC1_2113(bchH)
HMO: HM1_0682(bchH) HM1_0683(bchD) HM1_0684(bchI)
AWO: Awo_c10330(chlI1) Awo_c10340(chlI2)
MTUC: J113_06700
MAV: MAV_3706
MLP: MLM_1035
MPHL: MPHLCCUG_00944(bchI_1) MPHLCCUG_03211(bchI_2)
MTHN: 4412656_01684(bchI_1) 4412656_03765(bchI_2)
MAB: MAB_3157c
MABB: MASS_3101
MCHE: BB28_15990
MSTE: MSTE_03134
MTER: 4434518_00875(bchI_1) 4434518_03154(bchI_2)
ASD: AS9A_0146(chlI) AS9A_1609
CGL: NCgl1012(Cgl1057) NCgl1922(Cgl1997)
CDP: CD241_1436(chlI2)
CDH: CDB402_1400(chlI2)
CDT: CDHC01_1435(chlI2)
CDE: CDHC02_1388(chlI2)
CDR: CDHC03_1412(chlI2)
CDA: CDHC04_1412(chlI2)
CDZ: CD31A_1508(chlI2)
CDB: CDBH8_1485(chlI2)
CDS: CDC7B_1493(chlI2)
CDD: CDCE8392_1410(chlI2)
CDW: CDPW8_1481(chlI2)
CDV: CDVA01_1374(chlI2)
CDIP: ERS451417_01516(chlI2)
CKP: ckrop_0622(chlI1) ckrop_0623(chlH) ckrop_1154(chlI2)
COP: Cp31_1309
CPSE: CPTA_01871
CPSU: CPTB_01891
CPSF: CPTC_01865
CGV: CGLAU_04695(bchI)
CAQU: CAQU_07755
CAMG: CAMM_08735
NFR: ERS450000_05507(bchI_1) ERS450000_05830(bchI_2) ERS450000_05831(bchD)
NSR: NS506_06356(chlD)
RHS: A3Q41_02756(bchI_1) A3Q41_03635(bchI_2)
RHU: A3Q40_01400(bchI_1) A3Q40_02621(bchI_2)
SRT: Srot_2248
SCO: SCO1850(SCI8.35) SCO5277(2SC7G11.39) SCO5278(SCCB12.02)
SALB: XNR_4971
SMA: SAVERM_6414(chlI)
SGR: SGR_5643
SGB: WQO_07100
SCT: SCAT_1049
SFA: Sfla_4966
SBH: SBI_08143(chlI)
SHY: SHJG_3308
SVE: SVEN_1496
SALS: SLNWT_6021
STRP: F750_1712
SFI: SFUL_1426
SALU: DC74_2356
SALL: SAZ_13130
SLD: T261_6292
STRM: M444_09650
SPRI: SPRI_5671
SRW: TUE45_02328(bchI)
SLE: sle_52830(sle_52830)
SRN: A4G23_01079(bchI)
SNR: SNOUR_30945(chlI)
SMAL: SMALA_1813
SLAU: SLA_1406
SALF: SMD44_01998(chlD)
SALJ: SMD11_5143(chlD)
SLX: SLAV_28135(bchI)
SFK: KY5_1769
KSK: KSE_56400
ART: Arth_1986
ACH: Achl_1769
CGRN: 4412665_00461(bchI_1) 4412665_00462(bchI_2)
PPC: HMPREF9154_2917(bchI_1) HMPREF9154_2918(bchI_2)
NDK: I601_2004 I601_3844(bchI)
ACE: Acel_1892
MMAR: MODMU_0626(chlD) MODMU_0987
KRA: Krad_1097
SEN: SACE_2215 SACE_5965(chlI)
AMD: AMED_4934(chlI) AMED_7054(chlD)
AMM: AMES_4875(chlI) AMES_6946(chlD)
AMZ: B737_4875(chlI) B737_6946(chlD)
AOI: AORI_1678(chlD) AORI_3791(chlI)
AMQ: AMETH_3576(chlI) AMETH_5457(chlD)
PSEE: FRP1_12410
ACTI: UA75_14120
ACAD: UA74_14035
AHG: AHOG_13210(bchI)
SAQ: Sare_2709
ASE: ACPL_5085(chlI) ACPL_5304(chlI)
ACTN: L083_4033(chlI) L083_5175(chlD)
CAI: Caci_6039
RXY: Rxyl_0636
SYN: slr1030(chlI) slr1055(chlH) slr1777(chlD)
SYZ: MYO_12110(chlD) MYO_14700(chlH) MYO_15980(chlI)
SYY: SYNGTS_0211(chlD) SYNGTS_0464(chlH) SYNGTS_0591(chlI)
SYT: SYNGTI_0211(chlD) SYNGTI_0464(chlH) SYNGTI_0591(chlI)
SYS: SYNPCCN_0211(chlD) SYNPCCN_0464(chlH) SYNPCCN_0591(chlI)
SYQ: SYNPCCP_0211(chlD) SYNPCCP_0464(chlH) SYNPCCP_0591(chlI)
SYJ: D082_09190(chlI) D082_23950(chlD) D082_31650(chlH)
SYW: SYNW0213(chlD) SYNW0716(chlI) SYNW0820(chlH)
SYC: syc0940_c(chlI) syc1825_c(chlD) syc1955_c(chlH)
SYG: sync_0248(chlD) sync_0962(chlI) sync_1220(chlH)
CYA: CYA_0365(chlD) CYA_1319(chlH) CYA_1936(chlI)
CYB: CYB_0107(chlI) CYB_0714(chlD) CYB_0908(chlH)
TEL: tll1413(chlD) tll1511(chlI) tlr0271(chlH)
THN: NK55_00690(chlH) NK55_04185(bchD-1)
CYI: CBM981_1092(bchH) CBM981_1250(chlI) CBM981_2033(chlD)
LET: O77CONTIG1_02550(cobN_4) O77CONTIG1_02693(bchI_1) O77CONTIG1_03464(bchI_2)
HHG: XM38_001840(chlH_1) XM38_002520(chlI) XM38_009900(chlD) XM38_022390(chlH_2)
PMA: Pro_0319(chlD) Pro_0903(chlH) Pro_1146(chlI)
PMM: PMM0288(chlD) PMM0831(chlH) PMM1055(chlI)
PMB: A9601_03111(chlD) A9601_10391(chlH) A9601_11601(chlI)
PMC: P9515_03211(chlD) P9515_09061(chlH) P9515_11461(chlI)
PMF: P9303_08951(chlI) P9303_13931(chlH) P9303_25201(chlD)
PMG: P9301_03121(chlD) P9301_10391(chlH) P9301_11611(chlI)
PMH: P9215_03131(chlD) P9215_10711(chlH) P9215_11901(chlI)
PMJ: P9211_03141(chlD) P9211_09361(chlH) P9211_11361(chlI)
PME: NATL1_03681(chlD) NATL1_10621(chlH) NATL1_15321(chlI)
AMR: AM1_0533(chlD) AM1_4852(chlH) AM1_4907(chlI) AM1_5564(chlH)
MAR: MAE_12190(chlH) MAE_45780(chlD) MAE_48880(chlI) MAE_61570(chlH)
CYL: AA637_00395(chlH) AA637_07980(chlI) AA637_12890(chlD)
CYT: cce_0199(chlI) cce_0611(chlH2) cce_1074(chlD) cce_4358(chlH1)
ARP: NIES39_A01170(chlI) NIES39_D02700(chlH) NIES39_J04110(chlD)
GVI: gvip115(chlD) gvip235(chlI) gvip363(chlH) gvip458(chlH)
GLJ: GKIL_0959(cobN) GKIL_1677(chlD) GKIL_2248(chlH) GKIL_3305(chlI)
ANA: all0152(chlI) all0278(chlD) all4365(chlH) alr4733(chlH)
NSP: BMF81_00090(chlH) BMF81_00756(bchI) BMF81_02773(chlD)
TRO: trd_A0505
STI: Sthe_3485
DRA: DR_2594
TRA: Trad_2146
TTH: TT_C0268(chlI)
TTJ: TTHA0634
TAQ: TO73_0793
MRB: Mrub_2429
TTR: Tter_1872
RBA: RB309(chlI)
PSL: Psta_3300
PLM: Plim_1164
TTF: THTE_2670
GES: VT84_21180(bchI)
IPA: Isop_3536
ACA: ACP_1714
SUS: Acid_2208
ABAC: LuPra_04727(bchI)
GAU: GAU_0593(chlI)
GBA: J421_2518
SRU: SRU_2320
SRM: SRM_02545(chlI)
RMR: Rmar_2682
FLN: FLA_1264
PHE: Phep_0370
MUC: MuYL_0915
CHU: CHU_3739(yifB)
SLI: Slin_0326
FAE: FAES_0858
PSEZ: HME7025_00149(chlI)
HSW: Hsw_2544
FLM: MY04_4707
GFO: GFO_1975
GFL: GRFL_0063
FJO: Fjoh_4336
ZPR: ZPR_2266
MARM: YQ22_17015
CBAL: M667_17070
CBAT: M666_17090
DOK: MED134_05009(chlI1)
DDO: I597_2021
MLT: VC82_2757
NDO: DDD_0258
POM: MED152_12989(chlI)
WIN: WPG_2548
SPON: HME9304_03085(chlI)
MARF: CJ739_418
FBA: FIC_01721
CTE: CT0420 CT0421 CT1295(bchH-3) CT1296(bchD) CT1297(bchI) CT1955 CT1957(bchH-1)
PROC: Ptc2401_00749(bchI) Ptc2401_00750(bchD) Ptc2401_00751(cobN_1) Ptc2401_02045(cobN_2) Ptc2401_02046(cobN_3)
IAL: IALB_1711
MVO: Mvol_0687
METE: tca_00416(bchI_1) tca_00527(bchI_2)
MCUB: MCBB_0388
MKA: MK0192(chlI_chlD)
AFU: AF_1445
FPL: Ferp_2363
GAH: GAH_00932
TAC: Ta0576
TVO: TVG0623447(TVG0623447)
FAI: FAD_0586
PYN: PNA2_0539
TON: TON_1876
THE: GQS_05880
THS: TES1_0117
PPAC: PAP_03950
MAC: MA_0877
MBAK: MSBR3_1706
MMA: MM_2003(chlD)
MMAC: MSMAC_1740
MTHE: MSTHC_2045
MTHR: MSTHT_1248
MHOR: MSHOH_3344
MBU: Mbur_1433(bchI)
MTP: Mthe_0449
MCJ: MCON_0672(chlD) MCON_2217(chlD)
MBG: BN140_2367(chlD)
MEMA: MMAB1_3147(chlD)
MEZ: Mtc_1711
HAL: VNG_1565G(hmcA)
HSL: OE_3229R(chlID)
HHB: Hhub_2902(chlID)
HALH: HTSR_1847(chlI)
HHSR: HSR6_1916(chlD)
HMA: rrnAC3018(hmcA)
HHI: HAH_0273(hmcA)
NPH: NP_1094A(chlID)
NMO: Nmlp_1047(chlID)
HMU: Hmuk_1860
HWA: HQ_2295A(chlID)
HWC: Hqrw_2539(chlID)
HVO: HVO_B0051(chlID)
HME: HFX_5055(hmcA)
HLA: Hlac_3462
NAT: NJ7G_3582
MSE: Msed_2088
MCN: Mcup_0201
PIS: Pisl_0229
TNE: Tneu_0375
VDI: Vdis_1904
NEV: NTE_02229
NCV: NCAV_0314
NAA: Nps_03295
 » show all
Taxonomy
Reference
1  [PMID:11607197]
  Authors
Walker CJ, Weinstein JD.
  Title
In vitro assay of the chlorophyll biosynthetic enzyme Mg-chelatase: resolution of the activity into soluble and membrane-bound fractions.
  Journal
Proc Natl Acad Sci U S A 88:5789-93 (1991)
DOI:10.1073/pnas.88.13.5789
Reference
2  [PMID:9359397]
  Authors
Walker CJ, Willows RD.
  Title
Mechanism and regulation of Mg-chelatase.
  Journal
Biochem J 327 ( Pt 2):321-33 (1997)
Reference
3  [PMID:11469861]
  Authors
Fodje MN, Hansson A, Hansson M, Olsen JG, Gough S, Willows RD, Al-Karadaghi S.
  Title
Interplay between an AAA module and an integrin I domain may regulate the function of magnesium chelatase.
  Journal
J Mol Biol 311:111-22 (2001)
DOI:10.1006/jmbi.2001.4834
Other DBs
ExplorEnz - The Enzyme Database: 6.6.1.1
IUBMB Enzyme Nomenclature: 6.6.1.1
ExPASy - ENZYME nomenclature database: 6.6.1.1
BRENDA, the Enzyme Database: 6.6.1.1
CAS: 9074-88-8

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