KEGG   Equus przewalskii (Przewalski's horse): 103559577
Entry
103559577         CDS       T04644                                 
Symbol
IGF1R
Name
(RefSeq) insulin like growth factor 1 receptor
  KO
K05087  insulin-like growth factor 1 receptor [EC:2.7.10.1]
Organism
epz  Equus przewalskii (Przewalski's horse)
Pathway
epz01521  EGFR tyrosine kinase inhibitor resistance
epz01522  Endocrine resistance
epz04010  MAPK signaling pathway
epz04014  Ras signaling pathway
epz04015  Rap1 signaling pathway
epz04066  HIF-1 signaling pathway
epz04068  FoxO signaling pathway
epz04114  Oocyte meiosis
epz04140  Autophagy - animal
epz04144  Endocytosis
epz04150  mTOR signaling pathway
epz04151  PI3K-Akt signaling pathway
epz04152  AMPK signaling pathway
epz04211  Longevity regulating pathway
epz04213  Longevity regulating pathway - multiple species
epz04510  Focal adhesion
epz04520  Adherens junction
epz04550  Signaling pathways regulating pluripotency of stem cells
epz04730  Long-term depression
epz04913  Ovarian steroidogenesis
epz04914  Progesterone-mediated oocyte maturation
epz05200  Pathways in cancer
epz05202  Transcriptional misregulation in cancer
epz05205  Proteoglycans in cancer
epz05214  Glioma
epz05215  Prostate cancer
epz05218  Melanoma
epz05224  Breast cancer
epz05225  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:epz00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103559577 (IGF1R)
   04014 Ras signaling pathway
    103559577 (IGF1R)
   04015 Rap1 signaling pathway
    103559577 (IGF1R)
   04066 HIF-1 signaling pathway
    103559577 (IGF1R)
   04068 FoxO signaling pathway
    103559577 (IGF1R)
   04151 PI3K-Akt signaling pathway
    103559577 (IGF1R)
   04152 AMPK signaling pathway
    103559577 (IGF1R)
   04150 mTOR signaling pathway
    103559577 (IGF1R)
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    103559577 (IGF1R)
   04140 Autophagy - animal
    103559577 (IGF1R)
  09143 Cell growth and death
   04114 Oocyte meiosis
    103559577 (IGF1R)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    103559577 (IGF1R)
   04520 Adherens junction
    103559577 (IGF1R)
   04550 Signaling pathways regulating pluripotency of stem cells
    103559577 (IGF1R)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    103559577 (IGF1R)
   04914 Progesterone-mediated oocyte maturation
    103559577 (IGF1R)
  09156 Nervous system
   04730 Long-term depression
    103559577 (IGF1R)
  09149 Aging
   04211 Longevity regulating pathway
    103559577 (IGF1R)
   04213 Longevity regulating pathway - multiple species
    103559577 (IGF1R)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103559577 (IGF1R)
   05202 Transcriptional misregulation in cancer
    103559577 (IGF1R)
   05205 Proteoglycans in cancer
    103559577 (IGF1R)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    103559577 (IGF1R)
   05214 Glioma
    103559577 (IGF1R)
   05218 Melanoma
    103559577 (IGF1R)
   05215 Prostate cancer
    103559577 (IGF1R)
   05224 Breast cancer
    103559577 (IGF1R)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103559577 (IGF1R)
   01522 Endocrine resistance
    103559577 (IGF1R)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:epz01001]
    103559577 (IGF1R)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:epz04090]
    103559577 (IGF1R)
Enzymes [BR:epz01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     103559577 (IGF1R)
Protein kinases [BR:epz01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   103559577 (IGF1R)
CD molecules [BR:epz04090]
 Proteins
  103559577 (IGF1R)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like fn3 Kinase-like Insulin_TMD DUF4476
Other DBs
NCBI-GeneID: 103559577
NCBI-ProteinID: XP_008531456
Position
Un
AA seq 1578 aa
LGPASRTSPLAPLGARGRSAHGAGPAQRADSGDSSLGRAAPSLLGQTWCPVAGSPAARGV
QAAHDGEVPGRGPAAPGNVSKHPSAASCRPTCFAPRAPGLSRHFRLVRGELPVPGFPGLL
CAARGWGQRSCLDNPPPPTQPLERCEVEGPASVRLFRGARPGPLVQRVLGPSPSFYSPPG
GAGGVVGQHPRVREWVCGRGRRAFPHTCSQRGGVAAATRPRGDTYTPGPGERWCARRFAE
RQVCGPGIDIRNDYQQLKRLENCTVIEGYLHILLISKAEDYRSYRFPKLTVITEYLLLFR
VAGLESLGDLFPNLTVIRGWKLFYNYALVIFEMTNLKDIGLYNLRNITRGAIRIEKNADL
CYLSTVDWSLILDAVSNNYIVGNKPPKECGDLCPGTMEEKPLCEKTTINNEYNYRCWTTN
RCQKMCPSACGKRACTENNECCHPECLGSCSAPDNDTACVACRHYFYAGVCVPTCPPNTY
RFEGWRCVDRDFCANIPSAEGSDSEGFAIHDGECMQECPSGFIRNGSQSMYCIPCEGPCP
KVCEEEKKTKTIDSVTSAQMLQGCTIFKGNLLINIRRGNNIASELENFMGLIEVVTGYVK
IRHSHALVSLSFLKNLRQILGEEQLEGNYSFYVLDNQNLQQLWDWDHRNLTIKAGKMYFA
FNPKLCVSEIYRMEEVTGTKGRQSKGDINTRNNGERASCESDVLHFTSTTTWKNRIIITW
HRYRPPDYRDLISFTVYYKEAPFKNVTEYDGQDACGSNSWNMVDVDLPPNKDVEPGILLH
GLKPWTQYAVYVKAVTLTMVENDHIRGAKSEILYIRTNASVPSIPLDVLSASNSSSQLIV
KWNPPSLPNGNLSYYIVRWQRQPQDSYLYRHNYCSKDKIPIRKYADGTIDVEEVTENPKT
EVCGGEKGPCCACPKTEAEKQAEKEEAEYRKVFENFLHNSIFVPRPERKRRDVMQIANTT
MSSRSRNTTMADTYNVTDPEELETEYPFFESRVDNKERTVISNLRPFTLYRIDIHSCNHE
AEKLGCSASNFVFARTMPAEGADDIPGPVTWEPRPENSIFLKWPEPENPNGLILMYEIKY
GSQIEDQRECVSRQEYRKYGGAKLNRLNPGNYTARIQATSLSGNGSWTDPVFFYVPAKTT
YENFIHLIIALPVAVLLIVGGLVIMLYVFHRKRNNSRLGNGVLYASVNPEYFSAADVYVP
DEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLN
EASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPVLAPPSL
SKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKG
GKGLLPVRWMSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGG
LLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKDEMESGFREVSFYYSEENKPPE
PEELDLEPENMESVPLDPSASSSSLPLPDRHSGHKAENGPGPGVLVLRASFDERQPYAHM
NGGRKNERALPLPQSSTC
NT seq 4737 nt   +upstreamnt  +downstreamnt
ttggggccggcctcccgcacctcgcccctcgcccctctcggcgcgcggggccgctcagca
cacggtgctggccccgcgcagcgcgcagacagcggtgacagctccctcggccgcgcggcg
ccctcgctgctggggcagacttggtgcccggtggcggggagcccagcagcccgtggggtg
caagctgcccacgacggggaggtgcccggtaggggccccgcagccccaggaaacgtttcc
aaacaccccagcgcggcctcctgccgcccaacgtgctttgcccctagggctcctggcctt
tcccgtcactttcgcttggtccgcggcgagttacctgtccccggcttcccggggctgctc
tgtgcggctcgggggtgggggcaacgttcctgcctagacaaccccccgccccccacgcag
cctctggaaagatgcgaggtcgagggccctgcatcagtcaggctcttccggggagcgcgt
ccggggcccctggttcagagggtcctgggaccttctcccagtttctactctcctcctggc
ggggctggaggggtggttgggcagcatccgcgtgtgcgcgagtgggtgtgcggtcggggc
cgacgtgcatttccacacacgtgctcgcaacgcgggggtgtagccgctgccacacggccg
cgcggggacacctacacgcctggccctggcgagaggtggtgtgcgcggcggttcgcggag
cgccaggtctgcgggccgggcatcgacatccgcaacgactaccagcagctgaagcgcctg
gagaactgcacggtgatcgagggctacctccacatcctgctcatctccaaagcagaggac
taccgcagctaccgcttccccaagctcacggtcatcactgaatacttgctgctgttccgc
gtggccggcctcgagagccttggtgacctcttcccgaacctcacggtcatccgcggctgg
aaactcttctacaactacgccctggtcatcttcgagatgaccaatctcaaagatattggg
ctttacaacctgaggaacatcactcggggggccatcaggattgagaaaaatgctgacctt
tgttacctctccacggtggactggtccctgatcctggatgcagtgtccaataactacatc
gtgggaaacaaacccccaaaagaatgcggggacctgtgtccagggacaatggaggagaag
ccattgtgcgagaagaccaccatcaacaacgagtacaactaccgctgctggactacaaat
cgctgccagaaaatgtgcccgagcgcgtgcgggaagcgggcgtgcaccgagaacaacgag
tgctgccaccccgagtgcctgggcagctgcagcgcgcccgacaacgacacggcctgcgtc
gcctgccgccactacttctacgccggcgtctgcgtgcccacctgcccgcccaacacctat
cgctttgagggctggcgctgcgtggaccgcgacttctgtgccaacatccccagcgccgag
ggcagcgactctgagggcttcgcgatccacgacggcgagtgcatgcaggagtgcccctcg
gggttcatccgaaacggcagtcagagcatgtattgcatcccttgtgaaggtccttgcccc
aaagtctgtgaggaagaaaagaaaacaaagaccattgattctgttacttctgctcaaatg
ctccaaggatgcaccatcttcaagggcaatttgctcattaatatccgacgaggcaataac
attgcctcggaactggagaacttcatggggctcatcgaggtggtgacaggctacgtgaag
atccgccattcccacgccttagtctccttgtccttcctgaagaacctccgccagatctta
ggagaggagcagctggaggggaattactccttctacgtcctcgacaaccagaacttacag
cagctgtgggactgggaccaccgcaacctgaccatcaaagctgggaaaatgtacttcgct
ttcaatcccaaattgtgtgtctccgaaatttaccgcatggaggaagtgacgggcactaaa
gggcgccagagcaaaggggacatcaacaccaggaacaacggagagagagcctcctgtgag
agtgatgtcctgcacttcacctccaccaccacgtggaagaatcgcatcatcataacctgg
catcgctaccggccccctgactacagggacctcatcagcttcactgtctactacaaagag
gcaccctttaaaaacgtcacagagtatgatgggcaggatgcctgtggctccaacagctgg
aacatggtggatgtggacctccctcccaacaaggacgtcgagcctggcattctactgcac
gggctgaagccctggacgcagtacgccgtttacgtcaaggccgtgactctcaccatggta
gagaacgaccacattcgtggggccaagagtgaaatcttgtacattcgcaccaatgcttca
gttccttccatccccctggatgttctttcagcatcaaactcctcttctcagctaattgtg
aagtggaacccaccctctctgcccaacggcaacctgagttactacatcgtgagatggcag
cgacagcctcaggacagctacctttaccggcacaattactgctccaaagacaaaatcccc
atcaggaagtatgccgatggcaccattgatgttgaagaggtgacggagaatcccaagacc
gaagtgtgtggtggagagaaagggccttgctgtgcttgccccaaaaccgaagccgagaag
caggccgagaaggaggaagccgagtaccgcaaagtctttgagaatttcctgcacaactcc
atctttgtgcccagacctgaaaggaagcggagagatgtcatgcagattgccaacactacc
atgtccagccgaagcaggaacaccacgatggcagacacctacaatgtcacagacccagag
gagctggagacagaataccctttctttgagagcagagtggacaacaaggagaggactgtc
atttctaacctccggccattcactttgtaccgcattgacatccacagctgtaaccacgag
gctgagaagctaggctgcagtgcctccaacttcgtctttgcaagaaccatgcctgcagaa
ggagcagatgacattcctgggccggtgacctgggagccaaggcctgaaaattccatcttt
ttaaagtggccagaacctgagaatcccaatggattgattctaatgtatgaaataaaatat
ggatcacaaatcgaggatcagcgagaatgtgtatccagacaggagtacaggaagtatgga
ggggccaagcttaaccggctcaaccccgggaactatacggcccggatccaggccacctct
ctctctggaaatgggtcgtggactgatcctgtgttcttctatgtcccggccaaaacgaca
tatgaaaatttcatccatctgatcattgctctgcctgttgccgtcctgttgatagtggga
gggttggttataatgttgtacgtcttccatagaaaaagaaataacagcaggctggggaat
ggagtgctgtatgcatctgtgaacccagagtacttcagcgcagctgatgtgtatgtccct
gatgagtgggaggtcgctcgggagaagatcaccatgagccgagagctgggacagggctcc
tttgggatggtatatgaaggagttgccaagggcgtggtcaaagatgagcctgaaaccaga
gtggccattaaaacggtgaacgaggctgcaagcatgcgtgaaaggattgaatttctcaat
gaggcttcagtgatgaaggagttcaattgtcaccatgtggtgcggttgctgggtgtggtg
tcccagggccagccaacgctggtcatcatggagctgatgacacggggggatctcaaaagt
tatctcaggtctctgaggccagaaatggagaataatccagtcctagcacctccaagccta
agcaagatgatccagatggctggagagattgcagacggcatggcatacctcaatgccaac
aagttcgtccacagagaccttgccgcccggaactgcatggtggccgaagatttcacagtc
aaaattggagattttggtatgacgagagatatctatgagacagactattaccggaaagga
gggaagggattgctgcctgtgcgctggatgtcgcccgagtccctcaaggatggagtcttc
accactcattctgacgtctggtcctttggggttgtcctctgggagattgccacgctggcc
gagcagccataccagggcttgtccaacgagcaagtccttcgcttcgtcatggagggcggc
cttctagacaagccggacaactgccctgacatgctgtttgagctgatgcgcatgtgctgg
cagtacaaccccaagatgaggccttccttcctggagatcatcagcagcatcaaggacgag
atggagtctggctttcgggaggtctccttctactatagcgaggagaacaagccacccgag
ccagaggagctggacctggagccggagaacatggagagtgtccccctggacccctccgcc
tcctcgtcctccctgccgctgcccgacagacactcaggacacaaggccgagaacggccca
ggccctggcgtgctggttctccgagccagctttgatgagagacagccttacgcgcacatg
aacgggggacgcaagaacgagagggccttgcctctgccccagtcttcgacctgctga

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (29)   
   KEGG PATHWAY (29)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (4)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (49)   

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