KEGG   Escherichia coli O17 K52 H18 UMN026 (ExPEC): ECUMN_0076
Entry
ECUMN_0076        CDS       T00831                                 
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
eum  Escherichia coli O17:K52:H18 UMN026 (ExPEC)
Pathway
eum00290  Valine, leucine and isoleucine biosynthesis
eum00620  Pyruvate metabolism
eum01100  Metabolic pathways
eum01110  Biosynthesis of secondary metabolites
eum01210  2-Oxocarboxylic acid metabolism
eum01230  Biosynthesis of amino acids
Module
eum_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:eum00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    ECUMN_0076 (leuA)
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    ECUMN_0076 (leuA)
Enzymes [BR:eum01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     ECUMN_0076 (leuA)
SSDB
Motif
Pfam: HMGL-like LeuA_dimer
Other DBs
NCBI-ProteinID: CAR11299
UniProt: B7N7U9
Position
complement(86644..88215)
AA seq 523 aa
MSQQVIIFDTTLRDGEQALQASLSVKEKLQIALALERMGVDVMEVGFPVSSPGDFESVQT
IARQVKNSRVCALARCVEKDIDVAAESLKVAEAFRIHTFIATSPMHIATKLRSTLDEVIE
RAIYMVKRARNYTDDVEFSCEDAGRTPIADLARVVEAAINAGATTINIPDTVGYTMPFEF
AGIISGLYERVPNIDKAIISVHTHDDLGLAVGNSLAAVHAGARQVEGAMNGIGERAGNCS
LEEVIMAIKVRKDILNVHTAINHQEIWRTSQLVSQICNMPIPANKAIVGSGAFAHSSGIH
QDGVLKNRENYEIMTPESIGLNQIQLNLTSRSGRAAVKHRMDEMGYKESEYNLDNLYDAF
LKLADKKGQVFDYDLEALAFIGKQQEEPEHFRLDYFSVQSGSNDIATAAVKLACGEEVKA
EAANGNGPVDAVYQAINRITDYNVELVKYSLTAKGHGKDALGQVDIVANYNGRRFHGVGL
ATDIVESSAKAMVHVLNNIWRATEVEKELQRKAQHNENNKETV
NT seq 1572 nt   +upstreamnt  +downstreamnt
atgagccagcaagtcattattttcgataccacattgcgcgacggtgaacaggcgttacag
gcaagcttgagtgtgaaagaaaaactgcaaattgcgctggcccttgagcgtatgggtgtt
gacgtgatggaagtcgggttccccgtctcttcgccgggtgattttgaatcagtgcaaacc
atcgctcgccaggttaaaaacagccgcgtatgcgcgttagctcgctgcgtggaaaaggat
atcgacgtggcggccgaatctctgaaagtcgccgaagccttccggattcatacctttatt
gccacttcgccaatgcacattgccaccaagctgcgtagcacgctggacgaggtgatcgaa
cgcgctatctatatggtgaaacgcgcccgtaattacaccgatgatgttgaattttcttgc
gaagatgccggacgcaccccaattgccgatctggcgcgagtggtcgaagcggcgattaat
gccggtgccaccaccatcaacatcccggacaccgtgggctacaccatgccatttgagttc
gccggaatcatcagcgggctgtatgaacgcgtacccaacatcgacaaagccattatttcc
gtacatacccacgacgatttgggcctggcggtcggaaactcactggcggcggtacatgcc
ggtgcacgccaggtggaaggtgcaatgaacgggatcggcgagcgtgccggtaactgttcc
ctggaagaagtgatcatggcgatcaaagttcgtaaggatattctcaacgttcataccgcc
attaatcaccaggaaatatggcgcaccagccaattagttagccagatttgtaatatgccg
atcccggcaaacaaagccattgttggcagcggcgcattcgcacactcctccggtattcat
caggatggtgtgctgaaaaaccgcgaaaactacgaaatcatgacaccagaatctattggt
ttgaaccaaatccagctgaatctgacctctcgttcgggacgtgcggcagtaaaacaccgc
atggatgagatggggtataaagaaagtgaatataatttagacaatttgtacgatgccttc
ctgaagctggcggacaaaaaaggtcaggtgtttgattacgatctggaggcactggccttc
atcggtaagcagcaagaagagccggagcatttccgtctggattacttcagcgtgcagtct
ggctctaacgatattgccactgccgccgtcaaactggcctgcggcgaagaagtcaaagca
gaagccgccaacggtaacggtccggtcgatgccgtctatcaggcgataaaccgcatcact
gactataacgtcgaactggtgaagtacagcctgaccgccaaaggccacggtaaagatgcg
ctgggtcaggtggatattgtcgccaactacaatggtcgccgcttccacggcgtcggcctg
gccaccgatattgtcgagtcctccgccaaagccatggtgcacgtacttaacaatatctgg
cgtgccacagaagtcgaaaaagagttgcaacgcaaagctcaacacaacgaaaacaacaag
gaaaccgtgtga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   SWISS-PROT (1)   
Protein domain (2)   
   Pfam (2)   
All databases (24)   

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