KEGG   Felis catus (domestic cat): 101092961Help
Entry
101092961         CDS       T02385                                 

Gene name
PLCB3
Definition
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform X1
  KO
K05858  phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
fca  Felis catus (domestic cat)
Pathway
fca00562  Inositol phosphate metabolism
fca01100  Metabolic pathways
fca04015  Rap1 signaling pathway
fca04020  Calcium signaling pathway
fca04022  cGMP-PKG signaling pathway
fca04062  Chemokine signaling pathway
fca04070  Phosphatidylinositol signaling system
fca04071  Sphingolipid signaling pathway
fca04072  Phospholipase D signaling pathway
fca04261  Adrenergic signaling in cardiomyocytes
fca04270  Vascular smooth muscle contraction
fca04310  Wnt signaling pathway
fca04371  Apelin signaling pathway
fca04540  Gap junction
fca04611  Platelet activation
fca04621  NOD-like receptor signaling pathway
fca04713  Circadian entrainment
fca04720  Long-term potentiation
fca04723  Retrograde endocannabinoid signaling
fca04724  Glutamatergic synapse
fca04725  Cholinergic synapse
fca04726  Serotonergic synapse
fca04728  Dopaminergic synapse
fca04730  Long-term depression
fca04750  Inflammatory mediator regulation of TRP channels
fca04911  Insulin secretion
fca04912  GnRH signaling pathway
fca04915  Estrogen signaling pathway
fca04916  Melanogenesis
fca04918  Thyroid hormone synthesis
fca04919  Thyroid hormone signaling pathway
fca04921  Oxytocin signaling pathway
fca04922  Glucagon signaling pathway
fca04924  Renin secretion
fca04925  Aldosterone synthesis and secretion
fca04926  Relaxin signaling pathway
fca04927  Cortisol synthesis and secretion
fca04928  Parathyroid hormone synthesis, secretion and action
fca04933  AGE-RAGE signaling pathway in diabetic complications
fca04934  Cushing's syndrome
fca04961  Endocrine and other factor-regulated calcium reabsorption
fca04970  Salivary secretion
fca04971  Gastric acid secretion
fca04972  Pancreatic secretion
fca05010  Alzheimer's disease
fca05016  Huntington's disease
fca05142  Chagas disease (American trypanosomiasis)
fca05143  African trypanosomiasis
fca05146  Amoebiasis
fca05163  Human cytomegalovirus infection
fca05200  Pathways in cancer
Module
fca_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:fca00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101092961 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    101092961 (PLCB3)
   04310 Wnt signaling pathway
    101092961 (PLCB3)
   04371 Apelin signaling pathway
    101092961 (PLCB3)
   04020 Calcium signaling pathway
    101092961 (PLCB3)
   04070 Phosphatidylinositol signaling system
    101092961 (PLCB3)
   04072 Phospholipase D signaling pathway
    101092961 (PLCB3)
   04071 Sphingolipid signaling pathway
    101092961 (PLCB3)
   04022 cGMP - PKG signaling pathway
    101092961 (PLCB3)
 Cellular Processes
  Cellular community - eukaryotes
   04540 Gap junction
    101092961 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101092961 (PLCB3)
   04621 NOD-like receptor signaling pathway
    101092961 (PLCB3)
   04062 Chemokine signaling pathway
    101092961 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    101092961 (PLCB3)
   04922 Glucagon signaling pathway
    101092961 (PLCB3)
   04912 GnRH signaling pathway
    101092961 (PLCB3)
   04915 Estrogen signaling pathway
    101092961 (PLCB3)
   04921 Oxytocin signaling pathway
    101092961 (PLCB3)
   04926 Relaxin signaling pathway
    101092961 (PLCB3)
   04918 Thyroid hormone synthesis
    101092961 (PLCB3)
   04919 Thyroid hormone signaling pathway
    101092961 (PLCB3)
   04928 Parathyroid hormone synthesis, secretion and action
    101092961 (PLCB3)
   04916 Melanogenesis
    101092961 (PLCB3)
   04924 Renin secretion
    101092961 (PLCB3)
   04925 Aldosterone synthesis and secretion
    101092961 (PLCB3)
   04927 Cortisol synthesis and secretion
    101092961 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101092961 (PLCB3)
   04270 Vascular smooth muscle contraction
    101092961 (PLCB3)
  Digestive system
   04970 Salivary secretion
    101092961 (PLCB3)
   04971 Gastric acid secretion
    101092961 (PLCB3)
   04972 Pancreatic secretion
    101092961 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101092961 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    101092961 (PLCB3)
   04725 Cholinergic synapse
    101092961 (PLCB3)
   04728 Dopaminergic synapse
    101092961 (PLCB3)
   04726 Serotonergic synapse
    101092961 (PLCB3)
   04720 Long-term potentiation
    101092961 (PLCB3)
   04730 Long-term depression
    101092961 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    101092961 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101092961 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    101092961 (PLCB3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101092961 (PLCB3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    101092961 (PLCB3)
   05016 Huntington's disease
    101092961 (PLCB3)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    101092961 (PLCB3)
   04934 Cushing's syndrome
    101092961 (PLCB3)
  Infectious diseases
   05163 Human cytomegalovirus infection
    101092961 (PLCB3)
   05146 Amoebiasis
    101092961 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    101092961 (PLCB3)
   05143 African trypanosomiasis
    101092961 (PLCB3)
Enzymes [BR:fca01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101092961 (PLCB3)
Membrane trafficking [BR:fca04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101092961 (PLCB3)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101092961 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: PI-PLC-X PLC-beta_C PI-PLC-Y EF-hand_like C2 DUF1154
Motif
Other DBs
NCBI-GeneID: 101092961
NCBI-ProteinID: XP_023095762
Ensembl: ENSFCAG00000000507
Position
D1
AA seq 1249 aa AA seqDB search
MAGARPGVHALQLEPPTVVETLRRGSKFIKWDEEASSRNLVTLRVDPNGFFLYWTGPNME
VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDTRLEEKLMTVVAGPDPVNTTFLNF
MAVQDDTAKVWTEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS
ADKKRVETALESCGLNFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY
LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL
GGEENGILPLEALDLSADMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC
VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK
QQAKMAEYCRSIFGDALLIDPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHQPSTGVPNS
SIRKRPLEQSSSALSESSATTEPSSPQLGSPSSDSCLGLSNGEELGLEKPSLEPRKSLGE
EGLQRGPDALGSADREDEEEDEEEEEQADPKKPTSDEGTASSEVNATEEMSTLVNYIEPV
KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM
PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV
DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP
FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYICLRNEANQPLCLPALLI
YTEASDYIPDDHQDYAEALINPIKHVSLMDQRAKQLAALIGESEAQVGPETCQETPSQQP
VTPNPTPSTLDISPRRPPGPATSPTSPSLGSPGQRDDLIASLLSEVAPAPLDELRGHKAL
VKLRSRQERELRELHKKHQRKAVALTRRLLDSLAQARAERRCRQRPGVLHRPPSPSPCDN
LSVTQRGSSCRGGEDEKAEEEEVKRYREFQKRQVQSLLELREAQADTEAERRLEHLRQAQ
QRLREIVLDAHATQFKRLKETNEREKKELQKILDRKRHNSISEAKTREKHKKEAELTEIN
RRHITESVNSIRRLEEAQKQRHERLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQ
EACRSLLGETPEGLGDGHLVACASNGHAPGSGGHLSGADSESQEENTKL
NT seq 3750 nt NT seq  +upstreamnt  +downstreamnt
atggcgggcgccaggcccggcgtccacgcgctgcagctggagccgcccaccgtggtagag
accctgcggcgcgggagtaagttcatcaaatgggacgaggaggcttccagtcggaacctg
gtgaccctgcgtgtggaccccaatggcttcttcctgtactggacaggacccaacatggag
gtggacaccctggacatcagttccatcagggacacgcggacgggccgttatgcccgcctg
cccaaggaccccaagatccgagaggtgctgggctttggaggccctgacacccggctggag
gagaagttgatgacagtggtggccgggccagacccggtgaatacaacattcttgaacttc
atggccgtgcaggatgacacagccaaggtctggaccgaggagctgttcaagctggctatg
aacatcctggctcagaacgcctcccggaacacctttctgagaaaagcatacaccaagctg
aagctgcaggtaaaccaggatggacggatcccagtgaagaacatcctgaagatgttctca
gcagataagaagcgcgtcgagactgcgctggaatcctgtggcctcaatttcaaccggagt
gagtccatccggcccgacgagttctccttggaaatcttcgagcggttcctgaataagctg
tgtctgcggccagacattgacaagatcctgctggagataggcgccaagggcaagccatac
ctgacgctggagcagctcatggacttcatcaaccagaagcaacgggacccgaggctcaac
gaagtgctgtatccacccctgcggccctcccaggcccggctgctcattgagaagtatgag
cccaaccagcagttcctggaacgagaccagatgtccatggagggcttcagccgctacctg
gggggtgaggagaatggaatcctgcccttggaggccctggatctgagcgcagacatgacc
cagccgctaagcgcctacttcatcaactcctcacacaacacctatctcacagcggggcag
ctggctgggacgtcgtcggtggagatgtaccggcaggcactgctctggggctgccgctgc
gtggagctggacgtgtggaaagggcggcccccggaggaggagccctttatcacccacggc
ttcaccatgaccaccgaggtgccgctgcgagacgtgctcgaggccattgcggaaaccgcc
ttcaagacctcgccctaccctgtcatcctctccttcgagaaccacgtggactcggcaaag
caacaggcgaagatggccgagtactgtcgttcgatctttggggacgcgctgctcatcgac
ccactggacaagtacccgctggccccaggcgtcccgctgcccagcccccaggacctgatg
ggccgcatcctggtgaagaacaagaagcgacaccagcccagcactggtgtccccaacagc
tccattcgcaagcggccgctggagcagagcagctcggccctgagcgagagctctgccacc
accgagccctcctcgcctcagctcgggtcccccagctctgacagctgcctgggcctgagc
aatggggaagagctgggccttgagaagcccagcctggagcctcggaagtctctgggcgag
gaggggctacagcggggccctgatgctcttggatctgccgaccgtgaggacgaggaggaa
gacgaggaagaggaggaacaggcagatcccaaaaagccgacctcggatgagggcactgcc
agcagtgaagtcaatgccactgaggagatgtcaaccctcgtcaactacatcgagcctgtc
aagttcaagtcctttgaggctgctcgaaagaggaacaaatgcttcgagatgtcatccttc
gtggaaaccaaggccatggagcaactgaccaagagccccatggagtttgtggaatacaat
aaacaacagctcagccgcatctaccccaagggcacccgcgtggactcctccaactacatg
ccccagctcttctggaacgtgggctgccagcttgtggccctcaactttcagaccctggat
gtggcgatgcagctcaacgcgggtgtgtttgagtacaacggacgcagcggctacctgctc
aagcccgagttcatgcggcggccggacaagtccttcgaccccttcaccgaagtcatcgtg
gacggcatcgtggccaatgccttgcgggtcaaggtgatctcggggcagttcctgtccgac
aggaaggtgggcatctacgtggaggtggacatgtttggcctccccgttgacacacggcgc
aaataccgcactcggacgtctcaggggaactcattcaatcctgtgtgggatgaggaaccc
tttgacttccccaaggtggtgctccccacgctggcttcgctccgcatcgcggcctttgag
gaaggtggcaagtttgtggggcatcggattctgcccgtctctgccatccgttcagggtac
cactacatttgcctgcggaacgaggccaaccagccgctctgcctgccagccctgctcata
tacaccgaagcctccgactatattcctgatgaccaccaggactacgcagaggccctgatc
aaccccatcaagcatgtcagcctgatggaccagagggccaagcagttggccgccctcatc
ggggagagcgaggctcaggttggcccagaaacctgtcaggagactccatctcagcagccg
gtgaccccaaaccccacacccagcacactggacatctccccgcgccggcccccgggcccc
gccacgtcccctaccagcccctccctcggcagcccagggcagcgcgacgacctcatcgcc
agcctcctctcagaggtggccccggccccgctggacgagctccgaggccacaaggctctg
gtgaaactccggagccgtcaagagcgagagcttcgggagctgcacaagaagcatcagcgg
aaggcggttgccctcactcgccggttgctcgacagcttggcccaggcccgggctgagcgc
aggtgccggcagcggccgggtgtcctacaccgccctcccagcccgagtccctgtgacaac
ctgagtgtcacccagaggggttcttcctgcagaggcggggaggacgagaaggcggaggag
gaagaggtgaagcggtatcgagagttccagaagagacaggtgcagagtctgctggagctg
cgggaggcccaggcggatacagaggccgagcggaggctggagcatctgcgacaggctcag
cagcggctcagggagatcgtcctggatgctcacgccacccagttcaagcggctgaaggag
acgaatgagagggagaagaaggaactgcagaagattctggacaggaagcgccacaacagt
atctcagaagccaagacaagggagaaacataagaaggaggcggaactgacagagattaac
cgtcggcacatcaccgagtccgtcaactccatccgtcggctggaggaggcccagaagcag
cggcacgaacgccttgtggccgggcagcagcaggtgctgcagcagctggccgaagaagag
cccaagctgctggcccaactggcccaggagtgtcaggaacagcgggcaaggctgccccag
gaggcctgccggagcctgctgggcgagacgccggaggggctgggggacgggcatctggtg
gcctgtgccagcaatggtcacgcacctgggagcggcgggcacctgtctggcgctgactca
gagagccaagaggagaatacgaagctctga

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