KEGG   Felis catus (domestic cat): 101096000Help
Entry
101096000         CDS       T02385                                 

Gene name
PRKAA2
Definition
(RefSeq) 5'-AMP-activated protein kinase catalytic subunit alpha-2 isoform X1
  KO
K07198  5'-AMP-activated protein kinase, catalytic alpha subunit [EC:2.7.11.11]
Organism
fca  Felis catus (domestic cat)
Pathway
fca04068  FoxO signaling pathway
fca04140  Autophagy - animal
fca04150  mTOR signaling pathway
fca04151  PI3K-Akt signaling pathway
fca04152  AMPK signaling pathway
fca04211  Longevity regulating pathway
fca04213  Longevity regulating pathway - multiple species
fca04371  Apelin signaling pathway
fca04530  Tight junction
fca04710  Circadian rhythm
fca04714  Thermogenesis
fca04910  Insulin signaling pathway
fca04920  Adipocytokine signaling pathway
fca04921  Oxytocin signaling pathway
fca04922  Glucagon signaling pathway
fca04931  Insulin resistance
fca04932  Non-alcoholic fatty liver disease (NAFLD)
fca05410  Hypertrophic cardiomyopathy (HCM)
fca05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:fca00001]
 Environmental Information Processing
  Signal transduction
   04371 Apelin signaling pathway
    101096000 (PRKAA2)
   04068 FoxO signaling pathway
    101096000 (PRKAA2)
   04151 PI3K-Akt signaling pathway
    101096000 (PRKAA2)
   04152 AMPK signaling pathway
    101096000 (PRKAA2)
   04150 mTOR signaling pathway
    101096000 (PRKAA2)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    101096000 (PRKAA2)
  Cellular community - eukaryotes
   04530 Tight junction
    101096000 (PRKAA2)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    101096000 (PRKAA2)
   04922 Glucagon signaling pathway
    101096000 (PRKAA2)
   04920 Adipocytokine signaling pathway
    101096000 (PRKAA2)
   04921 Oxytocin signaling pathway
    101096000 (PRKAA2)
  Aging
   04211 Longevity regulating pathway - mammal
    101096000 (PRKAA2)
   04213 Longevity regulating pathway - multiple species
    101096000 (PRKAA2)
  Environmental adaptation
   04710 Circadian rhythm
    101096000 (PRKAA2)
   04714 Thermogenesis
    101096000 (PRKAA2)
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    101096000 (PRKAA2)
   05410 Hypertrophic cardiomyopathy (HCM)
    101096000 (PRKAA2)
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101096000 (PRKAA2)
   04931 Insulin resistance
    101096000 (PRKAA2)
Enzymes [BR:fca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.11  cAMP-dependent protein kinase
     101096000 (PRKAA2)
Protein kinases [BR:fca01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   101096000 (PRKAA2)
Membrane trafficking [BR:fca04131]
 Autophagy
  Other autophagy associated proteins
   Others
    101096000 (PRKAA2)
Mitochondrial biogenesis [BR:fca03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    101096000 (PRKAA2)
  Mitophagy factors
   Other mitophagy factors
    101096000 (PRKAA2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr AdenylateSensor Kinase-like RIO1 Kdo Haspin_kinase APH
Motif
Other DBs
NCBI-GeneID: 101096000
NCBI-ProteinID: XP_023114511
Ensembl: ENSFCAG00000003080
Position
C1
AA seq 552 aa AA seqDB search
MAEKQKHDGRVKIGHYVLGDTLGVGTFGKVKIGEHQLTGHKVAVKILNRQKIRSLDVVGK
IKREIQNLKLFRHPHIIKLYQVISTPTDFFMVMEYVSGGELFDYICKHGRVEEVEARRLF
QQILSAVDYCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGEFLRTSCGSPNYA
APEVISGRLYAGPEVDIWSCGVILYALLCGTLPFDDEHVPTLFKKIRGGVFYIPEYLNRS
VATLLMHMLQVDPLKRATIKDIREHEWFKQDLPSYLFPEDPSYDANVIDDEAVKEVCEKF
ECTESEVMNSLYSGDPQDQLAVAYHLIIDNRRIMNQASEFYLASSPPTGSFMDDSAMHIP
PGLKPHPERMPPLIADSPKARCPLDALNTTKPKSLAVKKAKWHLGIRSQSKPYDIMAEVY
RAMKQLDFEWKVVNAYHLRVRRKNPVTGNYVKMSLQLYLVDNRSYLLDFKSIDDEVVEQR
SGSSTPQRSCSAAGLHRPRSSFDSVTAESHSLSGSLTGSLTGSTLSSVSPRLGSHTMDFF
EMCASLITTLAR
NT seq 1659 nt NT seq  +upstreamnt  +downstreamnt
atggctgagaagcagaagcacgacgggcgggtgaagatcggacactacgtgctgggtgac
acgctgggcgtcggcaccttcggcaaagtgaagattggagaacatcaattgacaggccat
aaagtggcagttaaaatcttaaatagacagaagattcgcagtttagatgttgttggaaaa
ataaaacgagaaattcaaaatctaaaactctttcgccatcctcatattatcaaactatac
caggtgatcagcactccaacagatttttttatggtaatggaatatgtgtctggcggtgaa
ttatttgactacatctgtaaacatggacgggttgaagaggtggaagcaaggcgcctcttt
cagcagattctgtcagctgtggattactgtcataggcatatggtagttcatcgagacctg
aaaccagagaatgtgctgttggatgctcacatgaatgccaagatagcggattttggattg
tctaatatgatgtcggatggtgagtttctgcgaactagttgtggatctcccaattatgca
gcacctgaagtcatctcaggcagattgtatgcaggtcctgaagttgatatctggagctgt
ggtgttatcttgtatgctctcctttgtggcaccctcccatttgacgatgagcatgtacct
acgttatttaagaagatccgagggggtgttttttatatcccagaatatctcaatcgttct
gttgccactctgttgatgcatatgctgcaggttgaccccctgaaacgggcaactatcaaa
gatataagagagcatgaatggtttaaacaagatttgcccagttacttatttcctgaagac
ccctcctatgatgctaacgtcattgatgatgaggctgtgaaagaagtgtgtgaaaaattt
gagtgtacagaatcagaagtaatgaacagtttatatagtggtgaccctcaagaccagctt
gcagtggcttatcatcttatcattgacaatcggagaataatgaaccaagccagtgagttc
tacctcgcctctagtcccccaactggttcttttatggatgatagtgccatgcatattccc
ccaggcctgaagcctcatccagaaaggatgccacctcttatagcagacagccctaaagca
agatgtccattggatgcgctgaatacaactaagcccaaatctttagctgtgaaaaaagcc
aagtggcatcttggaatcagaagtcaaagcaaaccatatgacattatggccgaagtctac
cgagctatgaagcagctggattttgaatggaaggtagtgaatgcataccatcttcgtgta
agaaggaaaaatccagtgactggcaattatgtgaaaatgagcttacaactttacctggtt
gacaacagaagctatcttttggactttaaaagcattgatgatgaggtggtggagcagagg
tctggttcgtcaacacctcagcgttcctgttccgctgctggcttacacagacccagatca
agttttgattctgtaacagcagagagtcattcactctctggctctcttactggctccttg
acaggaagcacactgtcttctgtttcacctcgcctaggcagtcacaccatggattttttt
gaaatgtgtgctagtctgatcactactttggcccgttga

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