KEGG   Felis catus (domestic cat): 101099916Help
Entry
101099916         CDS       T02385                                 

Gene name
GRB2
Definition
(RefSeq) growth factor receptor-bound protein 2 isoform X1
  KO
K04364  growth factor receptor-binding protein 2
Organism
fca  Felis catus (domestic cat)
Pathway
fca01521  EGFR tyrosine kinase inhibitor resistance
fca01522  Endocrine resistance
fca04010  MAPK signaling pathway
fca04012  ErbB signaling pathway
fca04014  Ras signaling pathway
fca04062  Chemokine signaling pathway
fca04068  FoxO signaling pathway
fca04072  Phospholipase D signaling pathway
fca04150  mTOR signaling pathway
fca04151  PI3K-Akt signaling pathway
fca04380  Osteoclast differentiation
fca04510  Focal adhesion
fca04540  Gap junction
fca04550  Signaling pathways regulating pluripotency of stem cells
fca04630  Jak-STAT signaling pathway
fca04650  Natural killer cell mediated cytotoxicity
fca04660  T cell receptor signaling pathway
fca04662  B cell receptor signaling pathway
fca04664  Fc epsilon RI signaling pathway
fca04714  Thermogenesis
fca04722  Neurotrophin signaling pathway
fca04910  Insulin signaling pathway
fca04912  GnRH signaling pathway
fca04915  Estrogen signaling pathway
fca04917  Prolactin signaling pathway
fca04926  Relaxin signaling pathway
fca05034  Alcoholism
fca05160  Hepatitis C
fca05161  Hepatitis B
fca05163  Human cytomegalovirus infection
fca05165  Human papillomavirus infection
fca05200  Pathways in cancer
fca05203  Viral carcinogenesis
fca05205  Proteoglycans in cancer
fca05206  MicroRNAs in cancer
fca05210  Colorectal cancer
fca05211  Renal cell carcinoma
fca05213  Endometrial cancer
fca05214  Glioma
fca05215  Prostate cancer
fca05220  Chronic myeloid leukemia
fca05221  Acute myeloid leukemia
fca05223  Non-small cell lung cancer
fca05224  Breast cancer
fca05225  Hepatocellular carcinoma
fca05226  Gastric cancer
fca05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:fca00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    101099916 (GRB2)
   04010 MAPK signaling pathway
    101099916 (GRB2)
   04012 ErbB signaling pathway
    101099916 (GRB2)
   04630 Jak-STAT signaling pathway
    101099916 (GRB2)
   04068 FoxO signaling pathway
    101099916 (GRB2)
   04072 Phospholipase D signaling pathway
    101099916 (GRB2)
   04151 PI3K-Akt signaling pathway
    101099916 (GRB2)
   04150 mTOR signaling pathway
    101099916 (GRB2)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101099916 (GRB2)
   04540 Gap junction
    101099916 (GRB2)
   04550 Signaling pathways regulating pluripotency of stem cells
    101099916 (GRB2)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    101099916 (GRB2)
   04660 T cell receptor signaling pathway
    101099916 (GRB2)
   04662 B cell receptor signaling pathway
    101099916 (GRB2)
   04664 Fc epsilon RI signaling pathway
    101099916 (GRB2)
   04062 Chemokine signaling pathway
    101099916 (GRB2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    101099916 (GRB2)
   04912 GnRH signaling pathway
    101099916 (GRB2)
   04915 Estrogen signaling pathway
    101099916 (GRB2)
   04917 Prolactin signaling pathway
    101099916 (GRB2)
   04926 Relaxin signaling pathway
    101099916 (GRB2)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    101099916 (GRB2)
  09158 Development
   04380 Osteoclast differentiation
    101099916 (GRB2)
  09159 Environmental adaptation
   04714 Thermogenesis
    101099916 (GRB2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101099916 (GRB2)
   05206 MicroRNAs in cancer
    101099916 (GRB2)
   05205 Proteoglycans in cancer
    101099916 (GRB2)
   05203 Viral carcinogenesis
    101099916 (GRB2)
   05231 Choline metabolism in cancer
    101099916 (GRB2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    101099916 (GRB2)
   05225 Hepatocellular carcinoma
    101099916 (GRB2)
   05226 Gastric cancer
    101099916 (GRB2)
   05214 Glioma
    101099916 (GRB2)
   05221 Acute myeloid leukemia
    101099916 (GRB2)
   05220 Chronic myeloid leukemia
    101099916 (GRB2)
   05211 Renal cell carcinoma
    101099916 (GRB2)
   05215 Prostate cancer
    101099916 (GRB2)
   05213 Endometrial cancer
    101099916 (GRB2)
   05224 Breast cancer
    101099916 (GRB2)
   05223 Non-small cell lung cancer
    101099916 (GRB2)
  09165 Substance dependence
   05034 Alcoholism
    101099916 (GRB2)
  09172 Infectious disease: viral
   05161 Hepatitis B
    101099916 (GRB2)
   05160 Hepatitis C
    101099916 (GRB2)
   05163 Human cytomegalovirus infection
    101099916 (GRB2)
   05165 Human papillomavirus infection
    101099916 (GRB2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    101099916 (GRB2)
   01522 Endocrine resistance
    101099916 (GRB2)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:fca04131]
    101099916 (GRB2)
Membrane trafficking [BR:fca04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Receptor tyrosine kinase (RTK) adaptor proteins
    101099916 (GRB2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: SH3_1 SH3_9 SH3_2 SH2 SH3_10 SH2_2 hSH3 DUF5093 SH3_3 SH3_4
Motif
Other DBs
NCBI-GeneID: 101099916
NCBI-ProteinID: XP_023099758
Ensembl: ENSFCAG00000022474
Position
E1
AA seq 217 aa AA seqDB search
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
NT seq 654 nt NT seq  +upstreamnt  +downstreamnt
atggaagccatcgccaaatatgacttcaaagctactgctgacgacgagctgagcttcaaa
aggggggacatcctcaaggttttaaatgaagaatgtgatcagaactggtacaaggcagag
ctcaacgggaaagatggcttcattcccaagaattacatagaaatgaaaccacatccgtgg
ttttttggcaaaatccccagagccaaagcagaagaaatgcttagcaaacagcggcatgat
ggggcctttcttatccgagagagtgagagtgcccctggggacttctccctctccgtcaag
tttgggaatgacgtgcagcacttcaaggtgctccgagatggagctgggaagtacttcctc
tgggtggtgaaattcaactctttgaatgagctggtagattatcacagatctacatccgtg
tccagaaaccagcagatattcctccgggacatagaacaggtgccgcagcaaccaacatac
gtccaggccctctttgactttgatccccaggaggatggagagctgggattccgtcgggga
gactttatccacgtcatggataactcagatcccaactggtggaaaggggcctgccacggg
cagaccggcatgtttccccgcaattacgtcacccctgtgaaccggaacgtctaa

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