LOCUS DQ217792 19111 bp RNA linear VRL 22-FEB-2006
DEFINITION Lake Victoria marburgvirus - Musoke from Kenya, complete genome.
ACCESSION DQ217792
VERSION DQ217792.1
KEYWORDS .
SOURCE Marburg virus - Musoke, Kenya, 1980
ORGANISM Marburg virus - Musoke, Kenya, 1980
Viruses; Riboviria; Orthornavirae; Negarnaviricota;
Haploviricotina; Monjiviricetes; Mononegavirales; Filoviridae;
Orthomarburgvirus; Orthomarburgvirus marburgense.
REFERENCE 1 (bases 11291 to 19109)
AUTHORS Muhlberger,E., Sanchez,A., Randolf,A., Will,C., Kiley,M.P.,
Klenk,H.D. and Feldmann,H.
TITLE The nucleotide sequence of the L gene of Marburg virus, a
filovirus: homologies with paramyxoviruses and rhabdoviruses
JOURNAL Virology 187 (2), 534-547 (1992)
PUBMED 1546452
REFERENCE 2 (bases 1 to 19111)
AUTHORS Enterlein,S., Volchkov,V., Weik,M., Kolesnikova,L., Volchkova,V.,
Klenk,H.D. and Muhlberger,E.
TITLE Rescue of recombinant Marburg virus from cDNA is dependent on
nucleocapsid protein VP30
JOURNAL J. Virol. 80 (2), 1038-1043 (2006)
PUBMED 16379005
REFERENCE 3 (bases 1 to 19111)
AUTHORS Muhlberger,E.
TITLE Direct Submission
JOURNAL Submitted (21-SEP-2005) Department of Virology, Philipps University
Marburg, Robert-Koch-Str. 17, Marburg 35037, Germany
FEATURES Location/Qualifiers
source 1..19111
/organism="Marburg virus - Musoke, Kenya, 1980"
/mol_type="genomic RNA"
/strain="Musoke"
/db_xref="taxon:33727"
/country="Kenya"
misc_feature 1..48
/note="leader region"
gene 49..2844
/gene="NP"
mRNA 49..2844
/gene="NP"
/product="nucleoprotein"
CDS 104..2191
/gene="NP"
/note="nucleocapsid protein; encapsidates RNA genome"
/codon_start=1
/product="nucleoprotein"
/protein_id="ABA87124.1"
/translation="MDLHSLLELGTKPTAPHVRNKKVILFDTNHQVSICNQIIDAINS
GIDLGDLLEGGLLTLCVEHYYNSDKDKFNTSPIAKYLRDAGYEFDVIKNADATRFLDV
IPNEPHYSPLILALKTLESTESQRGRIGLFLSFCSLFLPKLVVGDRASIEKALRQVTV
HQEQGIVTYPNHWLTTGHMKVIFGILRSSFILKFVLIHQGVNLVTGHDAYDSIISNSV
GQTRFSGLLIVKTVLEFILQKTDSGVTLHPLVRTSKVKNEVASFKQALSNLARHGEYA
PFARVLNLSGINNLEHGLYPQLSAIALGVATAHGSTLAGVNVGEQYQQLREAAHDAEV
KLQRRHEHQEIQAIAEDDEERKILEQFHLQKTEITHSQTLAVLSQKREKLARLAAEIE
NNIVEDQGFKQSQNRVSQSFLNDPTPVEVTVQARPMNRPTALPPPVDDKIEHESTEDS
SSSSSFVDLNDPFALLNEDEDTLDDSVMIPGTTSREFQGIPEPPRQSQDLNNSQGKQE
DESTNPIKKQFLRYQELPPVQEDDESEYTTDSQESIDQPGSDNEQGVDLPPPPLYAQE
KRQDPIQHPAANPQDPFGSIGDVNGDILEPIRSPSSPSAPQEDTRMREAYELSPDFTN
DEDNQQNWPQRVVTKKGRTFLYPNDLLQTNPPESLITALVEEYQNPVSAKELQADWPD
MSFDERRHVAMNL"
gene 2854..4410
/gene="VP35"
mRNA 2854..4410
/gene="VP35"
/product="VP35"
CDS 2945..3934
/gene="VP35"
/note="nucleocapsid protein; polymerase cofactor; type I
interferon antagonist"
/codon_start=1
/product="VP35"
/protein_id="ABA87125.1"
/translation="MWDSSYMQQVSEGLMTGKVPIDQVFGANPLEKLYKRRKPKGTVG
LQCSPCLMSKATSTDDIIWDQLIVKRTLADLLIPINRQISDIQSTLSEVTTRVHEIER
QLHEITPVLKMGRTLEAISKGMSEMLAKYDHLVISTGRTTAPAAAFDAYLNEHGVPPP
QPAIFKDLGVAQQACSKGTMVKNATTDAADKMSKVLELSEETFSKPNLSAKDLALLLF
THLPGNNTPFHILAQVLSKIAYKSGKSGAFLDAFHQILSEGENAQAALTRLSRTFDAF
LGVVPPVIRVKNFQTVPRPCQKSLRAVPPNPTIDKGWVCVYSSEQGETRALKI"
gene 4415..5819
/gene="VP40"
mRNA 4415..5819
/gene="VP40"
/product="VP40"
CDS 4568..5479
/gene="VP40"
/note="matrix protein; budding; virus particle formation"
/codon_start=1
/product="VP40"
/protein_id="ABA87126.1"
/translation="MASSSNYNTYMQYLNPPPYADHGANQLIPADQLSNQQGITPNYV
GDLNLDDQFKGNVCHAFTLEAIIDISAYNERTVKGVPAWLPLGIMSNFEYPLAHTVAA
LLTGSYTITQFTHNGQKFVRVNRLGTGIPAHPLRMLREGNQAFIQNMVIPRNFSTNQF
TYNLTNLVLSVQKLPDDAWRPSKDKLIGNTMHPAVSIHPNLPPIVLPTVKKQAYRQHK
NPNNGPLLAISGILHQLRVEKVPEKTSLFRISLPADMFSVKEGMMKKRGENSPVVYFQ
APENFPLNGFNNRQVVLAYANPTLSAV"
gene 5825..8670
/gene="GP"
mRNA 5825..8670
/gene="GP"
/product="glycoprotein"
CDS 5941..7986
/gene="GP"
/note="surface protein; fusion; receptor binding"
/codon_start=1
/product="glycoprotein"
/protein_id="ABA87127.1"
/translation="MKTTCFLISLILIQGTKNLPILEIASNNQPQNVDSVCSGTLQKT
EDVHLMGFTLSGQKVADSPLEASKRWAFRTGVPPKNVEYTEGEEAKTCYNISVTDPSG
KSLLLDPPTNIRDYPKCKTIHHIQGQNPHAQGIALHLWGAFFLYDRIASTTMYRGKVF
TEGNIAAMIVNKTVHKMIFSRQGQGYRHMNLTSTNKYWTSSNGTQTNDTGCFGALQEY
NSTKNQTCAPSKIPPPLPTARPEIKLTSTPTDATKLNTTDPSSDDEDLATSGSGSGER
EPHTTSDAVTKQGLSSTMPPTPSPQPSTPQQGGNNTNHSQDAVTELDKNNTTAQPSMP
PHNTTTISTNNTSKHNFSTLSAPLQNTTNDNTQSTITENEQTSAPSITTLPPTGNPTT
AKSTSSKKGPATTAPNTTNEHFTSPPPTPSSTAQHLVYFRRKRSILWREGDMFPFLDG
LINAPIDFDPVPNTKTIFDESSSSGASAEEDQHASPNISLTLSYFPNINENTAYSGEN
ENDCDAELRIWSVQEDDLAAGLSWIPFFGPGIEGLYTAVLIKNQNNLVCRLRRLANQT
AKSLELLLRVTTEERTFSLINRHAIDFLLTRWGGTCKVLGPDCCIGIEDLSKNISEQI
DQIKKDEQKEGTGWGLGGKWWTSDWGVLTNLGILLLLSIAVLIALSCICRIFTKYIG"
gene 8768..10016
/gene="VP30"
mRNA 8768..10016
/gene="VP30"
/product="VP30"
CDS 8869..9714
/gene="VP30"
/note="nucleocapsid protein; binds to NP"
/codon_start=1
/product="VP30"
/protein_id="ABA87128.1"
/translation="MQQPRGRSRTRNHQVTPTIYHETQLPSKPHYTNYHPRARSMSST
RSSAESSPTNHIPRARPPSTFNLSKPPPPPKDMCRNMKIGLPCADPTCNRDHDLDNLT
NRELLLLMARKMLPNTDKTFRSPQDCGSPSLSKGLSKDKQEQTKDVLTLENLGHILSY
LHRSEIGKLDETSLRAALSLTCAGIRKTNRSLINTMTELHMNHENLPQDQNGVIKQTY
TGIHLDKGGQFEAALWQGWDKRSISLFVQAALYVMNNIPCESSISVQASYDHFILPQS
QGKGQ"
gene 9999..11285
/gene="VP24"
mRNA 9999..11285
/gene="VP24"
/product="VP24"
CDS 10207..10968
/gene="VP24"
/note="putative matrix protein"
/codon_start=1
/product="VP24"
/protein_id="ABA87129.1"
/translation="MAELSTRYNLPANVTENSINLDLNSTARWIKEPSVGGWTVKWGN
FVFHIPNTGMTLLHHLKSNFVVPEWQQTRNLFSHLFKNPKSTIIEPFLALRILLGVAL
KDQELQQSLIPGFRSIVHMLSEWLLLEVTSAIHISPNLLGIYLTSDMFKILMAGVKNF
FNKMFTLHVVNDHGKPSSIEIKLTGQQIIITRVNMGFLVEVRRIDIEPCCGETVLSES
VVFGLVAEAVLREHSQMEKGQPLNLTQYMNSKIAI"
gene 11291..19035
/gene="L"
mRNA 11291..19035
/gene="L"
/product="L protein"
CDS 11481..18476
/gene="L"
/note="polymerase; RNA-dependent RNA polymerase"
/codon_start=1
/product="L protein"
/protein_id="ABA87130.1"
/translation="MQHPTQYPDARLSSPIILDQCDLLARSLGLYSHYSHNPKLRNCR
IPHHIYRLRNSTALKTFLQNCSILTVPFHSIWDHILTSIQYDAINHVDDFKYLLPSEL
VKYANWDNEFLKAYLNKILGLDHVFSASARSQCEDFSPKENPYYWGMLLLVHLSQLAR
RIKGQRGSLRSNWKFIGTDLELFGIADFVIFKVPVKTIIRNAVSLQASKPGLRIWYRD
QNLTPYLCDDEFIVSVASYECFIMIKDVFIERYNTWEICARAWLEDSDGADYPPLDVL
GELYNQGDQIIAMYLEDGFKLIKHLEPLCVSCIQTHGIFTPRKYWFQSQMIKSYYDEL
HDLNLKLQISDNKAECAQNFIKTIVQAKLTPQQYCELFSLQKHWGHPVLYNDVALDKV
KKHAQSTKILKPKVMFETFCVFKFIVAKNHYHSQGSWYKTTHDLHLTPYLRQHIVSNS
FPSQAEIYQHLWEWYFVEHEPLFSTKIISDLSIFIKDRATAVNQECWDSVFDRSVLGY
NPPVRFQSKRVPEQFLGQADFSLNQILEFAEKLEYLAPSYRNFSFSLKEKELNIGRTF
GKLPYRVRNVQTLAEALLADGLAKAFPSNMMVVTEREQKEALLHQASWHHNSASIGEN
AIVRGASFVTDLEKYNLAFRYEFTRHFIDYCNRCYGVKNLFDWMHFLIPLCYMHVSDF
YSPPHCVTEDNRNNPPDCANAYHYHLGGIEGLQQKLWTCISCAQITLVELKTKLKLKS
SVMGDNQCITTLSLFPIDAPNDYQENEAELNAARVAVELAITTGYSGIFLKPEETFVH
SGFIYFGKKQYLNGVQLPQSLKTMARCGPLSDSIFDDLQGSLASIGTSFERGTSETRH
IFPSRWIASFHSMLAINLLNQNHLGFPLGFNIDISCFKKPLTFSEKLIALITPQVLGG
LSFLNPEKLFYRNISDPLTSGLFQLKNALEFLEKEELFYILISKKPGLADASDFVMNP
LGLNVPGSKEIITFLRQTVRENITITSQNRIINSLFHIGSDLEDQRVCEWLLSSNPVM
SRFAADIFSRTPSGKRLQVLGYLEGTRTLLASRTISLTTEGTMLMKLRELTRNRWKSW
FSYIDALDDDLSESLEKFTCTVDVANFLRAYSWSDVLKGKRLIGATLPCLLEQFEVKW
INLSEDLREQFNLSSDSKSTINLLPYDCKELRLEGSNDTELNYVSCALDRKVVQKHPS
VNRLAWTIGNRAPYIGSRTEDKIGYPPLRVNCPSAALKEAIEMVSRLLWVTQGTADRE
KLLIPLLNSRVNLDYQTVLNFLPTHYSGNIVHRYNDQYGQHSFMANRMSNTSTRAIIS
TNTLGKYAGGGQAAIDSNIIFQNTINLGVAVLDIALSLAKLSSASNVTFRLMLNKCCT
RHVPSEYLYFDKPLDVDLNKYMDNELVYDNDPLCSGIKGRLGRVSRSTLTLSLNVSDI
GSYDFPTIAAWTLGETIVGSIFSDESSQSTDPISSGCTKTFVTHFLVYPVESIFYAFG
ANLIVESLSLSRIKSIKNLSDLTFLISSTIRNLSHRSLRILQSTFRHELVLTRLAHHI
PLISLMLGGSAGEKSSSDAVRLFLTASYQNFINNFSCLMKKGQSSLPVWLYFPSEGQQ
LKPILKILQRLSDLLSPDKIQKRKILADTCCPIGSFWVYPSKSTRTNHYYASLNYWRD
KANKVKNTPFSHLINCSFPEFSSHTSSVSSNQQVTNSKYIVYPENITEINARTRLINY
GSTALQGMDTKMPLSEQNLVENCRPSEGIRFKDNQKITKHDQRCEREESSPQQMFPED
NMQTPAHIHSSSPFQILIKSLDAHEDFDASKIILNSEINNLNLTEYTLNTKLLTTPTR
TEILDTSPLQSSRYSSTSRERSLLSREQASYLYVDCSNIPSISLDPGFRSMSDQNQVQ
MLINTYKRDLHACFDSNQFCRFTGVVSSMHYKLYDLLPPGKLKKAICLAEGEGSGARL
LLKWKETDYLFFNTLATDSQQEAEILSGRVIPRMLYNIDRLSALLESRRLILNNLTIQ
ITDITNPLWLDSVIQYLPEDSDILTMDAETTKDETREQLYKTIVNIWTRTSPNIPKIS
IIKVFLLDYEGTLFLMKNAIQYYGQVQLKKPYSSNAKNSEWYLCCGKRRIQRLQIDFS
DQVGIFLICKAMSRQRQAIPYWLKHIEKNYPASLHEFFLTLGFPSLESSFCHRYTIPF
SEGKALFHKVQSYVRQGKQHLHSLMLDYENNSPLLDLRNHFICSLRGKITKYYNDILK
LNLVIKAVEKGKNWSQLVEILPNMHSVCIVHVDHECSGCEKRLLLKLDFIRNTKIAEQ
KLLNRVIGYILFFPFGLFKSGSLRA"
misc_feature 19036..19111
/note="trailer"
ORIGIN
1 agacacacaa aaacaagaga tgatgatttt gtgtatcata taaataaaga agaatattaa
61 cattgacatt gagacttgtc agtctgttaa tattcttgaa gagatggatt tacacagttt
121 gttggagttg ggtacaaaac ccactgcccc tcatgttcgt aataagaaag tgatattatt
181 tgacacaaat catcaggtta gtatctgtaa tcagataata gatgcaataa actcagggat
241 tgatcttgga gatctcctag aagggggttt gctgacgttg tgtgttgagc attactataa
301 ttctgataag gataaattca acacaagtcc tatcgcgaag tacttacgtg atgcgggcta
361 tgaatttgat gtcatcaaga atgcagatgc aacccgcttt ctggatgtga ttcctaatga
421 acctcattac agccctttaa ttctagccct taagacattg gaaagtactg aatctcagag
481 ggggagaatt gggctctttt tatcattttg cagtcttttc ctcccaaaac ttgtcgtcgg
541 agaccgagct agtatcgaaa aggctttaag acaagtaaca gtgcatcaag aacaggggat
601 cgtcacatac cctaatcatt ggcttaccac aggccacatg aaagtaattt tcgggatttt
661 gaggtccagc ttcattttaa agtttgtgtt gattcatcaa ggagtaaatt tggtgacagg
721 tcatgatgcc tatgacagta tcattagtaa ttcagtaggt caaactagat tctcaggact
781 tcttatcgtg aaaacagttc tcgagttcat cttgcaaaaa actgattcag gggtgacact
841 acatcctttg gtgcggacct ccaaagtaaa aaatgaagtt gctagtttca agcaggcgtt
901 gagcaaccta gcccgacatg gggaatacgc accatttgca cgggttctga atttatcagg
961 gattaacaac ctcgaacatg gactctatcc tcagctttca gcaattgcgc tgggtgtggc
1021 aacagcacac ggcagtacat tggctggtgt caatgttggc gaacaatatc aacaactacg
1081 agaggcggca catgatgcgg aagtaaaact acaaaggcga catgaacatc aggaaattca
1141 agctattgcc gaggatgacg aggaaaggaa gatattagaa caattccacc ttcagaaaac
1201 tgaaatcaca cacagtcaga cactagccgt cctcagccag aaacgagaaa aattagctcg
1261 tctcgctgca gaaattgaaa acaatattgt ggaagatcag ggatttaagc aatcacagaa
1321 tcgggtgtca cagtcgtttt tgaatgaccc tacacctgtg gaagtaacgg ttcaagccag
1381 gcccatgaat cgaccaactg ctctgcctcc cccagttgac gacaagattg agcatgaatc
1441 tacagaagat agctcttctt caagtagctt tgttgacttg aatgatccat ttgcactgct
1501 gaatgaggac gaggatactc ttgatgacag tgtcatgatc ccgggcacaa catcgagaga
1561 atttcaaggg attcctgaac cgccaagaca atcccaagac ctcaataaca gccaaggaaa
1621 gcaggaagat gaatccacaa atccgattaa gaaacagttt ctgagatatc aagaattgcc
1681 tcctgttcaa gaggatgatg aatcggaata cacaactgac tctcaagaaa gcatcgacca
1741 accaggatcc gacaatgaac aaggagttga tcttccacct cctccgttgt acgctcagga
1801 aaaaagacag gacccaatac agcacccagc agcaaaccct caggatccct tcggcagtat
1861 tggtgatgta aatggtgata tcttagaacc tataagatca ccttcttcac catctgctcc
1921 tcaggaagac acaaggatga gggaagccta tgaattgtcg cctgatttca caaatgatga
1981 ggataatcag cagaattggc cacaaagagt ggtgacaaag aagggtagaa ctttccttta
2041 tcctaatgat cttctgcaaa caaatcctcc agagtcactt ataacagccc tcgttgagga
2101 ataccaaaat cctgtctcag ctaaggagct tcaagcagat tggcccgaca tgtcatttga
2161 tgaaaggaga catgttgcga tgaacttgta gtccagataa cacagcacgg ttactcactt
2221 atctattttg atatgactca tcctcagatc acagcaatca aatttatttg aatatttgaa
2281 ccacctttta gtatcctatt acttgttact attgtgtgag acaacataag ccatcaaata
2341 acaatcacgg gcaaggactg ggcatactat ggtggtctta gagcattgtc cagtgctaca
2401 aattcttttt tcaattgcta taattataca actacaaacc tccatacatt tgccgcaaca
2461 ctgtaatcaa cactgctgta tctcttcttc aagccatctg atttaactta ataaacatga
2521 cttgattcaa agaatatact gacaatgtta ctgtttgaat ttctcaagtg gtgcactatc
2581 ctactgtttt gctcagctta gtatattgta atatgtaagt ggactctccc cttctcctct
2641 cgtgtattct ttataaatca cttacttgat agaatgtcga gtctactggt ttggagtttc
2701 cttactctaa tggatgtaat aattaactgt tggcctagat gataacagat atgaggttat
2761 ataattactc atagtgtaaa gtataattct tacctctgtt tcttctgttt tccctttctt
2821 ttataatatg ccaattaaga aaaactaaaa atcgaagaat attaaagatt ttctttaata
2881 ttcagaaaag gctttttatt ctattctttc tttttacaaa cgtattgaaa tagtaattct
2941 cacaatgtgg gactcatcat acatgcagca agtcagcgaa gggttgatga ctggaaaagt
3001 acccatagat caagtgtttg gtgccaatcc cttagagaag ttatacaaga gaagaaaacc
3061 aaaaggcaca gttggactac aatgtagccc ttgtctaatg tcaaaggcga caagtactga
3121 tgatattatt tgggaccaac tgatcgtgaa gagaacacta gctgatctac ttataccgat
3181 aaataggcag atatcagaca ttcaaagcac tctaagcgaa gtaacaacaa gagtccatga
3241 aattgagcgg caattacatg agattacccc agttttaaaa atgggaagga cactggaagc
3301 aatttccaag gggatgtcag aaatgttagc caaatacgac caccttgtaa tttcaactgg
3361 aagaaccact gcaccagctg ctgcctttga tgcctactta aatgagcatg gtgtccctcc
3421 ccctcaaccc gcgattttca aagatcttgg ggttgcccaa caagcttgta gtaaggggac
3481 catggttaaa aatgcaacaa cagatgcagc cgacaagatg tcgaaggttc ttgaactcag
3541 tgaggaaacg ttctccaagc caaacctttc agctaaggat ttagcccttt tattgtttac
3601 ccatctaccc ggcaacaaca ctccattcca tatcctagct caggtccttt caaaaattgc
3661 ttacaagtca ggaaaatccg gagcattctt ggatgcattt caccagattc taagtgaagg
3721 agagaatgct caggcggcat taactcgact aagcagaaca tttgacgctt tccttggagt
3781 ggttcctcca gtgataagag tcaaaaactt ccaaacagtc cctcgtccat gtcaaaaaag
3841 tcttcgggct gtccctccaa atccaacaat tgacaaagga tgggtctgtg tttattcatc
3901 tgagcaaggt gaaacacggg cccttaaaat ctaattctca ttgttcatag ttgcaaggga
3961 agtgatcttt ccgagttgat acaaagacac taaacatttc aaaagcatgt atgtggacaa
4021 aacataatta gaccatctta attggagtag taatttattt ctgtcttaaa tgtgattttc
4081 actttaaaag cgttaaatgg tgatagatta atccttgaag ttactcttct atatattata
4141 gagaaaccaa tgttactaac aaaaggggtc tacctaacgc atatgattga gtaatccgta
4201 tattttataa accaaacaat taacttctta ctttttaaga atcaactaac aacatagaaa
4261 agacatttat ccttatgtaa tcctcggctt agttgaaatt aacttttgtt ggacctcaag
4321 acgcttattc atagtatatt atatgatttt ttataagttt aagatatctt aaattatacc
4381 cacaaaagat actgttttaa ttaagaaaaa ctatgaagaa cattaagaag atctttcttt
4441 cgtagtgttc ttttactgga aggagtattc caatttcagc ttgttggatt aattgttact
4501 taaattgtcc tttttgaaat taattcacac aaggtagttt aaatttatat ccaaaataaa
4561 ttttgatatg gccagttcca gcaattacaa cacatacatg caatacttga acccccctcc
4621 ttatgctgat cacggtgcaa accagttgat cccggcggat cagctatcaa atcagcaggg
4681 tataactcca aattacgtgg gtgatttaaa cctagatgat cagttcaaag ggaatgtctg
4741 ccatgctttc actttagagg caataattga catatctgca tataacgagc gaacagtcaa
4801 aggcgttccg gcatggctgc ctcttgggat tatgagcaat tttgaatatc ctttagctca
4861 tactgtggcc gcgttgctca caggcagcta tacaatcacc caatttactc acaacgggca
4921 aaaattcgtc cgtgttaatc gacttggtac aggaatccca gcacacccac tcagaatgtt
4981 gcgtgaagga aatcaagctt ttattcagaa tatggtgatc cccaggaatt tttcaactaa
5041 tcaattcacc tacaatctca ctaatttagt attgagtgtg caaaaacttc ctgatgatgc
5101 ctggcgccca tccaaggaca aattaattgg gaacactatg catcccgcag tctccatcca
5161 cccgaatctg ccgcctattg ttctaccaac agtcaagaag caggcttatc gtcagcacaa
5221 aaatcccaac aatggaccat tgctggccat atctggcatc ctccatcaac tgagggtcga
5281 aaaagtccca gagaagacga gcctgtttag gatctcgctt cctgccgaca tgttctcagt
5341 aaaagagggt atgatgaaga aaaggggaga aaattccccc gtggtttatt ttcaagcacc
5401 tgagaacttc cctttgaatg gcttcaataa cagacaagtt gtgctagcgt atgcgaatcc
5461 aacgctcagt gccgtttgaa atgatgctca aatgagacag gagtccatct gtataagaag
5521 tatggcttaa atggatattt gtcaaattct tacaagatta gtttgtattg atttcaacaa
5581 tgctttaacc ttacattgct gctttaaata gttgattaag ctgatcagct tgtaatatgt
5641 aatctcttct gggccatcag atccataatg ggtttactag actatataag agaaatagta
5701 atattttata aacaattctt gctcagtttt actgtgattt aataacatat gtcattgtgc
5761 cctccattgc taagtcaact caactgacga taatactcct tctgaaatag taagaaaaac
5821 taatgaagaa cattaattgc tgggtaaaag tgattaattt ctttaaattt gaccagaata
5881 atattttgtc agtgaatata ttctcatatc acttgattaa aaacagaaaa ttaccctaac
5941 atgaagacca catgtttcct tatcagtctt atcttaattc aagggacaaa aaatctcccc
6001 attttagaga tagctagtaa taatcaaccc caaaatgtgg attcggtatg ctccggaact
6061 ctccagaaga cagaagacgt ccatctgatg ggattcacac tgagtgggca aaaagttgct
6121 gattcccctt tggaggcatc caagcgatgg gctttcagga caggtgtacc tcccaagaat
6181 gttgagtaca cagaggggga ggaagccaaa acatgctaca atataagtgt aacggatccc
6241 tctggaaaat ccttgctgtt agatcctcct accaacatcc gtgactatcc taaatgcaaa
6301 actatccatc atattcaagg tcaaaaccct catgcacagg ggatcgccct tcatttatgg
6361 ggagcatttt ttctgtatga tcgcattgcc tccacaacaa tgtaccgagg caaagtcttc
6421 actgaaggga acatagcagc tatgattgtc aataagacag tgcacaaaat gattttctcg
6481 cggcaaggac aagggtaccg tcatatgaat ctgacttcta ctaataaata ttggacaagt
6541 agtaacggaa cgcaaacgaa tgacactgga tgtttcggcg ctcttcaaga atacaattct
6601 acaaagaacc aaacatgtgc tccgtccaaa atacctccac cactgcccac agcccgtccg
6661 gagatcaaac tcacaagcac cccaactgat gccaccaaac tcaataccac ggacccaagc
6721 agtgatgatg aggacctcgc aacatccggc tcagggtccg gagaacgaga accccacaca
6781 acttctgatg cggtcaccaa gcaagggctt tcatcaacaa tgccacccac tccctcacca
6841 caaccaagca cgccacagca aggaggaaac aacacaaacc attcccaaga tgctgtgact
6901 gaactagaca aaaataacac aactgcacaa ccgtccatgc cccctcataa cactaccaca
6961 atctctacta acaacacctc caaacacaac ttcagcactc tctctgcacc attacaaaac
7021 accaccaatg acaacacaca gagcacaatc actgaaaatg agcaaaccag tgccccctcg
7081 ataacaaccc tgcctccaac gggaaatccc accacagcaa agagcaccag cagcaaaaaa
7141 ggccccgcca caacggcacc aaacacgaca aatgagcatt tcaccagtcc tccccccacc
7201 cccagctcga ctgcacaaca tcttgtatat ttcagaagaa agcgaagtat cctctggagg
7261 gaaggcgaca tgttcccttt tctggatggg ttaataaatg ctccaattga ttttgaccca
7321 gttccaaata caaaaacaat ctttgatgaa tcctctagtt ctggtgcctc ggctgaggaa
7381 gatcaacatg cctcccccaa tattagttta actttatctt attttcctaa tataaatgag
7441 aacactgcct actctggaga aaatgagaat gattgtgatg cagagttaag aatttggagc
7501 gttcaggagg atgacctggc cgcagggctc agttggatac cgttttttgg ccctggaatt
7561 gaaggacttt acactgctgt tttaattaaa aatcaaaaca atttggtctg caggttgagg
7621 cgtctagcca atcaaactgc caaatccttg gaactcttat tgagagtcac aactgaggaa
7681 agaacattct ccttaatcaa tagacatgct attgactttc tactcacaag atggggagga
7741 acatgcaaag tgcttggacc tgattgttgc atcgggatag aagacttgtc caaaaatatt
7801 tcagagcaaa ttgaccaaat taaaaaggac gaacaaaaag aggggactgg ttggggtctg
7861 ggtggtaaat ggtggacatc cgactggggt gttcttacta acttgggcat tttgctacta
7921 ttatccatag ctgtcttgat tgctctatcc tgtatttgtc gtatctttac taaatatatc
7981 ggataacgtt aaatgtgtaa tgattaggac tttaggacaa ttgctactga gccctttttc
8041 taatctactg aaatcaactt gggagatttt taagaagctg ataacttaat gtgaatcaat
8101 agtttatgta ttatcgatta ttatggtttg atattcaatt gttattattg tcaggagtga
8161 ccttttctat ttgatgcatt aatgttttaa actacctctt aagcctttga gggcggtccc
8221 aatatgtgcg taggggttaa tttaaaggga tttcttattg tacagttttc tgtattactt
8281 atttgggctt gaagacatag ttaagatttg ccgaaaatgc tctccagtca attccatccc
8341 ctctcagaaa agacgtgctg ttcaaagagt cttaatttat aaccaactat tgcaagaatt
8401 aatttacttt ttccgttata cttagttaca ttaatctttt gactgttcag cattattaac
8461 gacttgtctt aattcaatcg ttcggatgaa attcataagg aaaaatgagc ctccttcccc
8521 ctattctggg ctgagaaaat ttctcttatc cgcctaaaat ctgatctgtt aggtcatggg
8581 tccttcataa tctgtttgag catgaatatt gatcaaatga ccaaatgata gtgcatttgt
8641 atagactcaa ttatccttta ttaagaaaaa gataaataga acacaaagaa ttgacaaaat
8701 tttactttga ttgattttgc aaggagttat aaaaatcttg aaggataaat tgttataaag
8761 tagagtcgaa gaacattaaa tgttctttgt tagaattatt catctaagtt gtttttgagt
8821 atattcgctt caatacaact cctctttata tttgatttaa gttttaaaat gcaacaacct
8881 cgcggaagaa gtcgaacccg caaccaccaa gtcacaccga ctatatatca tgaaactcaa
8941 ttgccctcca aacctcatta taccaattat catccacgtg caagatcgat gagctcaacc
9001 cgtagtagtg cagaaagtag tcccaccaat catattcccc gtgctcgacc accctcaaca
9061 ttcaacttat cgaaaccccc tcctcctcca aaagacatgt gcaggaacat gaaaattgga
9121 ttgccgtgcg ctgatcccac ttgtaataga gatcatgacc ttgataatct aacaaatcgt
9181 gaacttttgc tattgatggc ccgaaaaatg ctccccaata cagacaagac ctttagaagt
9241 ccgcaggact gtggatcacc gtctctttct aaaggtctct caaaagataa acaggagcaa
9301 acgaaagatg tgttgacctt ggaaaatcta ggacacattc tgagctatct ccacagatca
9361 gaaattggga aattggatga gacatcactt cgtgcagcat taagtctgac gtgtgctgga
9421 attcgaaaga cgaatagatc cttgatcaac accatgacag aattacacat gaaccatgaa
9481 aatctcccgc aagaccaaaa cggtgttatc aagcagacct atacaggtat tcaccttgac
9541 aaaggaggtc aattcgaagc cgccttatgg caaggttggg ataagagatc gatatctcta
9601 ttcgtacaag cagctttata tgtaatgaac aatatcccct gtgaatcatc aatcagtgtg
9661 caagcctcat acgatcattt tattcttcct caaagtcaag gtaaaggaca gtgattattg
9721 ttcgaaagtt gacaatttga tcactttcag ttttcagttt caacccttat cgcgagactt
9781 gaatacaatc ctactaactt caataagtga ccccaaattc aagtttgctg aaagctaaga
9841 tgacaatgat cactagttca ttgtaaatta ctcgatcaaa atgttcttaa gctatcttaa
9901 gcttactgat gcggctctgc ttcacttttc ttttgatttt aaagccatag ctatatctaa
9961 gtgtctaatt aacaacttgt acctctaagg aaaaacatga agaacattaa gaaaaaggat
10021 gttcttattc tttgactaaa cctgcatatt ctttgttgat accctcgaga gacaactttt
10081 gacaccagat cacggatcaa gcacacttca atcaagcacc ctaaattttc aatcatacac
10141 ataataacca ttttagtagc gttgcctttc agtacagtct aggtgattgt tgaaagactt
10201 ccaagcatgg cagaattatc aacgcgttac aacttgcctg caaatgttac ggaaaatagt
10261 ataaatcttg accttaattc cacagcacga tggataaaag aacccagtgt tgggggctgg
10321 acagtgaagt ggggaaactt tgttttccat ataccaaata ctggaatgac attgttgcat
10381 catttaaagt ctaacttcgt tgttccagag tggcaacaaa caaggaatct attctcccac
10441 ctctttaaaa acccaaaatc aacaattata gaaccgtttt tggccctgag gattttgctt
10501 ggagttgctt tgaaggatca agaattacag caatcattga ttcctggatt tagatctatt
10561 gttcatatgc tatcagaatg gctgctcctg gaggtcacgt cggcaatcca tattagccct
10621 aatctgttgg gaatctattt gacttcagac atgtttaaaa ttctgatggc aggtgtgaaa
10681 aatttcttca ataagatgtt cactcttcat gttgtaaatg accacggaaa acccagcagt
10741 attgaaataa agttaactgg acaacagatc attatcactc gtgttaatat ggggtttcta
10801 gtggaagtca ggaggattga tattgaacct tgctgtggtg agacagtcct ctcagaatca
10861 gttgtttttg gactagtggc tgaggcagtt ctaagagaac acagtcaaat ggagaagggc
10921 caacctctca atctgacaca atacatgaac agcaaaattg ctatataagt ggcttaaatt
10981 agcatgggta ttcctagttc gaccacataa taatgttgga ggcacagtac attatagtta
11041 attgtcttgt atactaaggg atatacctaa cctgatttat atttactggt ataaaatagt
11101 agcatcatct tattgaatag ttatcataca ataggctgtt cctataatct gattgtgaga
11161 ttataaactt gtagaattac cgtgggtcac aactgttgca tatcctccaa aatatatctt
11221 ttgcaagtga tgtgtgcttg aatacttcga tataatacat actaataacg attgattaag
11281 aaaaatcaat gatggatatt aaatgtccat caagcaagtg ttgtagaata ccaggggttt
11341 cacaggctgc taaacttact aaattttaca taggattata taattctttt cgatacacgt
11401 tatatcttta gcaaagtgag gaaaacagct ttatcatgtt agatgccagt tatccatttt
11461 aagtgaatcc tttcctcaac atgcagcatc caactcaata tcctgatgca aggttgtcct
11521 ctcctataat cctagaccag tgtgacttat tagccagaag tttagggttg tatagtcatt
11581 attcacataa tccgaaattg cgtaattgta ggattccaca tcacatttac cgtttaagga
11641 attcgacagc attaaagaca tttcttcaga attgttcgat actcaccgtt ccttttcatt
11701 caatttggga tcatatttta acttccattc aatatgatgc aattaatcat gttgatgatt
11761 ttaaatacct attgccatct gagctagtca agtatgcgaa ttgggacaac gagttcttaa
11821 aagcatatct taataagatc ttaggacttg accatgtttt ttcagcttct gcaaggtcac
11881 agtgtgagga tttttctcct aaggaaaatc cttattattg ggggatgtta ttactcgtgc
11941 atctatctca acttgccagg aggataaaag gacaaagagg gtcattaaga agtaactgga
12001 aatttatagg aacagatttg gagctgtttg gaatagcaga ttttgttatt tttaaggttc
12061 cagtaaaaac aataatccga aatgctgtaa gcttacaagc ttcaaaaccg ggattaagaa
12121 tatggtaccg tgaccaaaac ttgacccctt atctatgcga cgatgagttt attgtaagcg
12181 tcgctagtta tgaatgtttt atcatgatta aagacgtctt cattgagagg tataacacat
12241 gggaaatctg tgcccgcgct tggctcgaag acagtgatgg agctgattat cctcctcttg
12301 atgtgttagg tgaattatac aaccagggag accaaattat tgccatgtac ctggaggacg
12361 gtttcaaatt gattaaacac ttagaaccct tgtgtgtcag ctgtatacaa acacatggca
12421 tctttacacc aagaaaatac tggttccaat cacagatgat taagtcatat tatgatgaac
12481 tccatgatct caatttgaaa cttcaaattt cagacaataa ggctgagtgt gcccaaaact
12541 ttattaaaac tatagttcag gcgaaattga ctcctcaaca atactgtgaa ttattctccc
12601 tacaaaagca ttggggtcat cccgttttat acaatgatgt tgcactagat aaggttaaaa
12661 aacatgcgca atcgacaaaa atcttaaaac ctaaagtcat gtttgaaact ttttgtgttt
12721 tcaaatttat agtagcaaag aatcattatc attctcaagg atcatggtat aaaaccacac
12781 atgatttgca tttgactcca tatcttagac aacatattgt gtcaaattca tttccatcac
12841 aagccgaaat ttatcagcat ctttgggagt ggtatttcgt ggagcatgaa cctcttttct
12901 caactaaaat aataagtgat ttaagtatct ttataaaaga cagggctacc gctgtgaacc
12961 aggagtgttg ggacagtgtc ttcgatagaa gtgtattagg atataaccct cctgttagat
13021 ttcaatcaaa gagagtgcca gagcaatttt tgggtcaagc agacttttcc ttgaatcaaa
13081 tattagagtt tgctgaaaag ttagagtatt tggctccttc ttataggaat ttttccttct
13141 cattaaaaga aaaagagttg aatataggaa gaacttttgg gaagttaccg tatcgtgtca
13201 gaaatgtcca aacactcgca gaagccctgc tagcagatgg actggcaaaa gcattcccta
13261 gtaacatgat ggttgtcact gagagggaac agaaagaagc attattacat caggcttctt
13321 ggcaccacaa ttcagcaagc ataggggaga acgctatagt gaggggtgca agttttgtta
13381 ctgatcttga gaaatacaac ctcgccttcc gatatgaatt tacacggcat ttcatagact
13441 actgtaatcg atgttatggt gtgaagaatt tatttgattg gatgcatttt ttaataccac
13501 tatgttatat gcatgtcagt gacttttata gcccaccaca ttgtgtgaca gaagataatc
13561 gaaataaccc acctgattgt gctaatgctt atcattatca cttaggaggt atagagggac
13621 ttcagcagaa attgtggaca tgcatatcat gtgcccaaat cacccttgtg gagttaaaaa
13681 ctaaattaaa attgaagtcc agcgtcatgg gtgataatca atgtataaca actctaagtc
13741 tttttccaat tgatgctccc aacgattatc aagagaacga ggctgaattg aatgcggcac
13801 gagttgctgt cgaattagct attactacag gttatagtgg tatattttta aagcctgagg
13861 aaacatttgt ccattcaggg ttcatttatt ttggtaaaaa gcaatatctc aacggtgttc
13921 aactgccgca atcattgaaa acaatggcaa ggtgtggacc cttatctgac tctattttcg
13981 atgatcttca aggttctctg gccagtattg gtacatcctt tgagagagga acaagcgaga
14041 cacggcacat ttttccgagc cgttggatag cttcattcca ttcaatgtta gcaataaatt
14101 tattaaatca gaatcacctt gggtttcctc tagggttcaa tattgatatt tcttgtttca
14161 aaaagcctct taccttctcg gaaaaattaa ttgctctcat aacgccccaa gttttaggag
14221 ggttatcatt tttaaatcca gaaaaattgt tctaccggaa cataagtgat cctctcactt
14281 caggtctatt tcaactcaag aatgcattgg aatttcttga aaaggaagaa ttattctata
14341 tcttgatttc taaaaaacct ggtttagcag atgcctcaga ttttgtcatg aatccattag
14401 gcttaaatgt accaggatca aaggaaataa taacgttcct tagacaaaca gttcgcgaaa
14461 atatcacgat cacgtcacaa aatagaataa taaattctct tttccacata ggttctgatt
14521 tagaggacca aagagtgtgt gagtggcttt tatcatcaaa ccctgtaatg agccgatttg
14581 ctgctgacat cttttcaaga acacctagtg gaaaacggct tcaagtctta ggctatctag
14641 aaggaacaag aacattacta gcttctcgga caatcagttt aactacagaa ggaacaatgt
14701 tgatgaaatt aagagaatta acgagaaacc gatggaaaag ttggttttct tatattgatg
14761 cactggacga tgatttatct gagtccttgg aaaagttcac atgtactgtt gatgtggcta
14821 atttcttgag ggcatattca tggtctgacg tcttaaaagg gaaaaggcta attggtgcca
14881 cactgccatg tttactagag caatttgagg taaagtggat taatttatct gaggatttaa
14941 gggaacaatt taatctatct tcagactcaa aatcaactat aaacttgttg ccgtatgact
15001 gtaaggaact gcgacttgaa ggaagcaatg acacagagtt aaattatgtc agttgtgctc
15061 ttgaccggaa agttgtccag aaacatccct ctgttaatcg tctagcttgg acgataggaa
15121 atcgagcacc gtatattggc tcacggacag aagataagat cggttatcct cccttaagag
15181 taaattgccc atcagcagca cttaaagaag ctattgagat ggtttctaga ttgttatggg
15241 tgactcaagg cactgcagac cgagaaaaat tgcttattcc tcttctcaat tcaagagtaa
15301 atctggacta tcagacggtg cttaactttt tacctacaca ctactcaggc aacatagttc
15361 atagatataa tgatcaatat ggacaacatt cctttatggc aaacaggatg agtaatacat
15421 ctacacgtgc aattatatca actaacacac tgggtaaata tgctggggga ggtcaagctg
15481 ctattgatag taatataatc tttcaaaata ctattaattt aggagttgca gttttagata
15541 ttgcattgtc tcttgctaaa ttgtcgtcag catcaaatgt cactttccgt ttaatgttaa
15601 ataagtgctg cacgcggcat gtaccgtccg aatacctata ttttgataaa cctttagatg
15661 tggatttgaa caagtatatg gacaatgagt tggtttatga caatgaccct ctttgcagtg
15721 ggattaaagg gagattaggc agagtatctc gatcaacact cacattgagt ttgaatgtca
15781 gtgacattgg ttcttatgac tttccaacta ttgctgcatg gacactagga gaaactatag
15841 tcggaagcat tttttctgat gaatcttctc aaagtacgga tccaataagc tcaggttgca
15901 caaaaacttt cgtcacacat ttccttgtgt atccagttga gagtatattt tatgcattcg
15961 gagctaactt aatagttgaa agtttaagtc taagtaggat caaatcaatt aagaacctct
16021 cagatttgac attccttata tcatccacaa tcaggaattt atcacataga tcacttcgga
16081 ttcttcaatc tactttccga catgaattgg tgctcacccg actagcccac cacataccgt
16141 taatttcttt aatgttaggg ggctctgcag gagagaagag ttcatcagat gctgttcggc
16201 tatttcttac agcaagttat cagaatttta tcaataattt cagttgtctg atgaagaagg
16261 gtcagtcatc gctaccggtt tggctttact ttcctagtga agggcaacaa ttaaagccta
16321 tattaaaaat cttacagaga ttatcagact tgttatcacc tgacaaaatt caaaagcgta
16381 aaattttggc tgacacctgt tgtccaattg gcagcttttg ggtctatcca agcaagtcca
16441 caaggactaa ccattattat gcaagcctta attattggag agacaaagct aataaggtta
16501 agaatactcc tttttcacac ttgataaatt gttcatttcc tgaattttct tcacatacca
16561 gttcagtctc ctctaatcaa caagtgacca attcgaagta tattgtttat ccagaaaata
16621 tcactgaaat aaatgcaaga accagattaa taaattatgg atcaacagct ctacagggga
16681 tggacaccaa gatgccactc tcagagcaaa atctagtcga aaattgtcga ccatcagagg
16741 gcatcagatt caaggacaat caaaaaataa caaaacatga ccagagatgt gagagggagg
16801 aatcttcacc gcaacagatg ttccctgaag ataacatgca gactcctgcg cacatacata
16861 gttcctcccc atttcaaatc cttataaaat cactagatgc acatgaggac tttgatgcct
16921 cgaagataat cttaaattct gaaataaata atcttaacct tacggagtat actcttaata
16981 caaagttatt gacaactcct accaggacag aaattttaga tacaagtccg ttacaatcct
17041 ctagatattc atcaacttcc agggaacggt ctctactatc cagagaacaa gcttcatatt
17101 tgtacgttga ttgcagtaat attccttcta tctctctaga cccaggtttt cggagtatgt
17161 ctgatcagaa tcaagttcaa atgttaatca atacctacaa acgtgattta catgcttgtt
17221 ttgatagcaa tcaattctgt cggtttacag gggtagtctc atcaatgcat tacaagcttt
17281 atgatctttt gcctccaggt aaattgaaaa aggcaatttg tttggccgaa ggggaaggaa
17341 gtggtgctcg gttacttttg aagtggaagg aaacggatta tttattcttc aacactttgg
17401 ctacggattc acaacaagaa gccgagattt tgagtggccg ggtaataccg agaatgttgt
17461 ataacataga cagattaagt gctttgcttg aatcaaggag actaatattg aacaacctaa
17521 ctatccaaat tacagatatt acaaatccat tatggctaga ttctgtaata caatatttac
17581 ctgaagatag tgacattctt acaatggacg cagagaccac caaggatgaa acaagggaac
17641 agctttataa aactattgtg aatatttgga cacgtacttc tcctaatatc ccaaaaatta
17701 gcatcatcaa ggtattttta ttagactatg aagggacttt attcttaatg aagaatgcta
17761 ttcagtatta tgggcaagtt caactcaaga aaccatatag ctcaaatgca aaaaactcag
17821 aatggtactt gtgttgcggt aaacgaagaa ttcaacggct ccaaattgat ttctcagacc
17881 aggtgggaat ttttctgatt tgtaaagcaa tgtcacgcca aagacaagca attccttact
17941 ggttaaaaca tatagaaaag aattatcctg cttcattaca cgagtttttc ctaactttgg
18001 gtttcccttc tttagagtca tctttctgcc atcgttatac tattccattc agtgaaggaa
18061 aggctctttt tcacaaggtc cagtcttatg ttcgtcaagg caaacaacat ttacattctc
18121 ttatgttgga ttatgaaaac aattcacctc tactagactt gagaaatcac tttatttgct
18181 cattaagggg aaagataact aaatattaca atgatatatt aaagttaaat ctagtcatca
18241 aggcagtaga aaaaggtaaa aattggtcac aacttgttga gatccttcct aatatgcatt
18301 cagtatgcat agtgcacgtg gatcatgagt gttctggatg cgagaaacgg ttattactta
18361 aattggattt tatcagaaat acaaagatcg cagaacaaaa attacttaac agagtaatcg
18421 ggtatatcct attctttcca ttcggtctgt ttaaatctgg atcattaagg gcataatttc
18481 aacagagaga acttcattta attcacaaaa acaatctatt taagagtgag ggttacattg
18541 tctaagatat tgtatgagaa gtaataaaat aaataagaaa acgaaaagac tattagacag
18601 cttattttat acaagataat cttatatcgc tttaggcctc acacaagtga gaaaattacg
18661 cgcacagatt aactagtgat tagtgtttgg tcacaccaga ggtaactttt taacgttaat
18721 tactcagatg ttattgctca taattagcat taatattggc acattgggtg aatccttgag
18781 ctttatccct aatatggtgt aagaaattaa ggaaatactg agatacacta gttgaattga
18841 attatgacat accatatatc ataaatataa aaaagtgtct gctgtaatct acaagcacct
18901 cttttaaata cattaggaaa agaattaagt taccgttgag atcaaaaaaa ccacgtcatg
18961 ttttctctga tgacaagtga taaaacttcg tagttaaatt tctagaatgt cgatgtgaat
19021 gtaaattaag aaaaaccaat atataaaatt aaaaaattaa aaagctttga tataagtaac
19081 acaaaacatt cttcatcttt tttgtgtgtc c
//