LOCUS EU004678 7386 bp RNA linear VRL 19-SEP-2007
DEFINITION Murine norovirus GV/CR10/2005/USA, complete genome.
ACCESSION EU004678
VERSION EU004678.1
KEYWORDS .
SOURCE Murine norovirus GV/CR10/2005/USA
ORGANISM Murine norovirus GV/CR10/2005/USA
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes;
Picornavirales; Caliciviridae; Norovirus; Norwalk virus.
REFERENCE 1 (bases 1 to 7386)
AUTHORS Thackray,L.B., Wobus,C.E., Chachu,K.A., Liu,B., Alegre,E.R.,
Henderson,K.S., Kelley,S.T. and Virgin,H.W. IV.
TITLE Murine noroviruses comprising a single genogroup exhibit biological
diversity despite limited sequence divergence
JOURNAL J. Virol. 81 (19), 10460-10473 (2007)
PUBMED 17652401
REFERENCE 2 (bases 1 to 7386)
AUTHORS Thackray,L.B., Wobus,C.E., Chachu,K.A., Liu,B., Alegre,E.R.,
Henderson,K.S., Kelley,S.T. and Virgin,H.W. IV.
TITLE Direct Submission
JOURNAL Submitted (18-JUN-2007) Pathology and Immunology, Washington
University School of Medicine, Box 8118, 660 S. Euclid Ave., St.
Louis, MO 63110, USA
FEATURES Location/Qualifiers
source 1..7386
/organism="Murine norovirus GV/CR10/2005/USA"
/mol_type="genomic RNA"
/isolate="Mu/NoV/GV/CR10/2005/USA"
/isolation_source="feces of genetically modified C57BL6
mouse"
/host="mouse"
/db_xref="taxon:463724"
/country="USA"
/collection_date="Oct-2005"
/note="passaged twice"
5'UTR 1..5
CDS 6..5072
/note="ORF1; encodes helicase, protease, and polymerase"
/codon_start=1
/product="polyprotein"
/protein_id="ABU55612.1"
/translation="MRMATPSSAPSVRNTEKRKNKKASSKANVSFGAPSLLSSESEDE
ANYLTPPEQEAQPGTLAALHADGPHAGLPVTRSDARVLIFNDWEERKKSEPWLRLDMS
DKAIFRRFPHLRPKEDKADAPSHAEDAMDAREPVVGSILEQDDHKFYHYSVYIGNGMV
MGVNNPGAAVCQAVIDVEKLHLWWRPVWEPPQPLDPAELRKCVGMTVPYVATTVNCYQ
VCCWIVGIKDTWLKRAKISRNLPFYSPVQDWNVDPQEPFIPSKLRMVSDAILVALSTV
IGRPIKNLLASVKPLNILNIVLSCDWTFSGIVNALILLAELFDIFWTPPDVTNWMISI
FGEWQAEGPFDLALDVVPTLLGGIGMAFGLTSETIGRKLASTNSALKAAQEMGKFAIE
VFKQIMAWIWPSEDPVPALLSNMEQAVIKNECQLENQLTAMLRDRNAGAEFLKALDEE
EQEVRKIAAKCGNSATTGTTNALLARISMARAAFEKARAEQTSRVRPVVIMVSGRPGI
GKTCFCQNLAKRIAASLGDETSVGIIPRADVDHWDAYKGARVVLWDDFGMDNVVKDAL
RLQMLADTCPVTLNCDRIENKGKMFDSQVIIITTNQQTPVPLDYVNLEAVCRRIDFLV
YAESPVVDAARARAPGDVNAVKAAMRQDYSHINFILAPQGGFDRQGNTPYGKGVTKII
GATALCARAVALVHERHDDFGLQNKVYDFDAGKATAFKTMAADAGIPWYRMATIGYKA
MGCTCVEEAMNLLKDYEVAPCQVIYNGATYNVSCIKGTPMVEKVXEPELPKTLVNCVR
RIKEARLRCYCRMATDVITSILQAAGTAFSIYHQIEKKSRPSFYWDHGYTYRDGPGAF
DLFEDDNDDGWYHSESKKGKNKKGRGRPGVFKSRGLTDEEYDEFKKRRESRGGKYSID
DYLADREREEELQERDEEEAVFGDGLGLKATRRSRKAERARLGLISGGDIRARKPIDW
NVVGPSWADDERQVDYGEKINFEAPVSIWSRVVQFGTGWGFWVSSHVFITAKHVAPPK
GTEVFGRKPDEFTVTSSGDFLKYNFTSAVRPDIPAMVLENGCQEGVVASVLIKRASGE
MLALAVRMGSQAAIKIGSAVVHGQTGMLLTGSNAKAQDLGTIPGDCGCPYVYKKGNTW
VVIGVHVAATRSGNTVIAATHGEPTLEALEFQGPPMLPRPTGTYAGLPIADYGDAPPL
STKTMFWRTSPEKLPPGAWEPAYLGSKDERVDGPSLQQVMRDQLKPYSEPRGLLPPQE
ILDAVCDAIENRLENTLEPQKPWTFKKACESLDKNTSSGHPYHKQKSKDWTGTAFIGD
LGDQATHANNMYEMGKSMRPVYTAALKDELVRPDKIYKKIKKRLLWGSDLGTMIRAAR
AFGPFCDALKETCIFNPIRVGMSMNEDGPFIFARHANFRYHMDADYSRWDSTQQRAIL
KRAGDIMVRLSPEPELARVVMDDLLAPSLLDVGDYKIVVEEGLPSGCPCTTQLNSLAH
WILTLCAMVEVTRIDPDIVMQESEFSFYGDDEVVSTNLELDMTKYTMALRRYGLLPTR
ADKEEGPLERRQTLQGISFLRRAIVGDQFGWYGRLDRASIDRQLLWTKGPNHLNPFET
LPGHAQRPSQLMALLGEAAMHGEKYYRTVASRVSKEAAHSGIEMVVPRHRSVLRWVRF
GTMDAETPQERSAVFVNEDE"
CDS 5059..6684
/codon_start=1
/product="capsid protein"
/protein_id="ABU55613.1"
/translation="MRMSDGAAPKANGSEASGQDLVPTAVEQAVPIQPVAGSALAAPA
AGQINQIDPWIFQNFVQCPLGEFSISPRNTPGEILFDLALGPGLNPYLAHLSAMYTGW
VGNMEVQLVLAGNAFTAGKVVVALVPPYFPKGSLTTAQITCFPHVMCDVRTLEPIQLP
LLDVRRVLWHATQDQEESMRLVCMLYTPLRTNSPGDESFVVSGRLLSKPAADFNFVYL
TPPIERTIYRMVDLPVLQPRLCTHARWPAPIYGLLVDPSLPSNPQWQNGRVHVDGTLL
GTTPVSGSWVSCFAAEAAYEFQSGTGEVATFTLIEQDGSAYVPGDRAAPLGYPDFSGQ
LEIEVQTETTKTGDKLKVTTFEMILGPTTNVDQAPYQGRVYASLTAVASLDLVDGRVR
AVPRSIYGFQDVIPEYNDGLLVPLAPPIGPFLPGEVLLRFRTYMRQLDTADAAAEAID
CALPQEFISWFASNAFTVQSDALLLRYRNTLTGQLLFECKLYSEGYIALSYSGSGPLT
FPTDGFFEVVSWVPRLFQLASVGSLTTGRTLKQ"
CDS 6684..7310
/codon_start=1
/product="small basic protein"
/protein_id="ABU55614.1"
/translation="MAGALFGAIGGGLMGIIGNSISTVQNLQANKQLAAQQFGYNSSL
LATQIQAQKDLTLMGQQFNQQLQANSFKHDLEMLGAQVQAQAQAQENAINIRSAQLQA
AGFSKSDAVRLASGQQPTKSVDWSGTRYYTANQPVTGFSGGFTPSYTPGRQMTSRPVD
TSPLPVLGGRLPSLRGGSWSPRDYTPATQGTYTNGRFVSLPKIGSSRA"
3'UTR 7311..7386
ORIGIN
1 gtgaaatgag gatggcaacg ccatcttctg cgccctctgt gcgcaacaca gagaaacgca
61 aaaacaaaaa ggcttcatct aaggctaacg tctcctttgg agcgcctagc cttctctctt
121 cggagagtga agatgaagct aactatttga cccctcctga gcaggaagct cagcccggca
181 cccttgcggc ccttcatgct gacgggccgc acgccgggct ccctgtgaca cgaagtgacg
241 cacgcgtgct gatcttcaat gattgggagg agaggaagaa gtccgagccg tggctacggc
301 tggacatgtc tgataaggcc atcttccgcc gctttcccca cctgcggcct aaggaagaca
361 aggctgacgc gccctcccat gcggaggacg ccatggatgc aagagagcct gtggtgggat
421 ccattcttga acaggatgat cacaagttct aycactactc tgtctacatt gggaatggca
481 tggtgatggg cgtcaacaac cctggcgccg ccgtctgcca ggccgtgatc gatgtagaga
541 aactccattt gtggtggaga ccagtctggg aaccccccca gcccctcgac ccggctgagt
601 tgaggaaatg tgtaggcatg actgttccct acgtggcaac caccgtcaac tgctaccaag
661 tttgctgctg gattgttggg atcaaggaca cctggctgaa gagggccaag atctctagga
721 acttgccctt ctacagcccc gtccaggatt ggaatgttga cccccaggag cccttcattc
781 catccaagct caggatggtt tctgatgcca tcctggttgc cctctcaacg gtgattggtc
841 ggccgatcaa gaacctgctg gcatctgtga agcccctcaa cattctcaat atcgtgttga
901 gctgtgactg gactttctcg ggtatagtca atgccctgat ccttcttgct gagctctttg
961 acatcttctg gacccccccc gatgtcacca actggatgat ctccatcttt ggggaatggc
1021 aggccgaagg ccctttcgac ctcgccttgg atgttgtgcc cacccttctt ggtgggattg
1081 gcatggcctt cggtctgaca tctgagacca ttgggcgcaa gctcgcctcc accaactcag
1141 ccctgaaggc cgcccaggag atgggcaagt ttgcaattga ggtcttcaaa cagatcatgg
1201 catggatctg gccctctgag gatccagtgc ctgctctgct ctccaacatg gaacaggctg
1261 tcatcaagaa tgagtgtcag cttgagaacc agctcacggc tatgttgcgg gaccgcaatg
1321 ctggagctga gttcttgaag gcgcttgatg aagaagagca ggaggtccgc aagattgcgg
1381 ccaagtgtgg gaattctgcc actacgggca cgactaacgc cctgttggct aggatcagca
1441 tggctcgcgc agcctttgag aaggctcgcg ctgagcaaac ctcccgggtc cgtcccgtgg
1501 tgatcatggt ctctggcagg cccgggatcg ggaagacctg cttctgtcaa aacctggcaa
1561 agagaattgc cgcctccctt ggagatgaga cctcggtcgg catcataccg cgtgctgacg
1621 tggaccactg ggatgcctac aagggcgcca gagtggtcct ctgggatgac tttggtatgg
1681 acaatgtggt gaaggacgct ctgcggctgc agatgctcgc cgacacatgc cctgtcacgc
1741 tcaactgtga tagaattgag aacaaaggta aaatgtttga ctcccaagtg attatcatca
1801 ccaccaacca acagacccca gtacccttgg attatgtcaa cctggaggca gtttgccgcc
1861 gcatagactt tctggtctat gccgagagcc ccgtggttga tgctgcccgg gctagggcgc
1921 ctggcgacgt gaacgccgtc aaggccgcca tgaggcaaga ctacagccac atcaacttca
1981 tcttggcacc ccagggtggt tttgaccggc agggtaatac cccctatggc aagggcgtca
2041 ccaagatcat tggcgccacc gcgctctgcg caagggcagt tgctctcgtt catgagcgcc
2101 atgatgattt tggcctccaa aacaaggtct atgattttga tgctggcaag gccaccgcct
2161 tcaagaccat ggcggctgat gccggcatcc cttggtacag gatggcaaca attggctaca
2221 aggccatggg ttgcacctgt gtggaagagg ccatgaattt gctcaaggac tatgaggtgg
2281 ccccatgtca agtgatctac aacggagcca cctataatgt cagctgtatc aaggggaccc
2341 ctatggttga gaaggtcarg gagcctgagt tgcccaagac actagtcaac tgtgtcagga
2401 gaatcaagga ggcccgcctc cgctgctact gtcggatggc cacagatgtc atcacctcca
2461 tcttgcaggc ggccggaacg gccttctcca tctaccacca gattgagaag aagtccaggc
2521 cctccttcta ctgggatcac ggctacacct accgtgatgg cccaggtgcc ttcgacctct
2581 ttgaggatga caatgatgat gggtggtacc actctgaaag caagaagggc aagaacaaga
2641 agggccgggg gcgycctgga gttttcaagt cccgtgggct cacggacgag gagtatgatg
2701 agttcaagaa gcgccgcgag tccaggggcg gaaaatactc cattgatgac tacctcgctg
2761 accgcgagcg agaagaagag ctccaggagc gtgacgaaga agaggccgtc ttcggggatg
2821 gtcttggcct gaaggccacg cgccgctccc gcaaggcaga gagagccagg cttggcctaa
2881 tctcgggcgg tgacatccgc gcccgcaagc caatcgactg gaacgtggtt ggcccctcct
2941 gggctgatga cgagcgccag gtcgattatg gtgagaagat caactttgag gccccagtct
3001 ccatctggtc ccgtgttgtg caattcggca cgggttgggg cttctgggtc agcagccacg
3061 tgttcatcac cgccaagcac gtggcaccgc ccaagggtac ggaggttttc gggcgcaaac
3121 ccgatgaatt cactgtcacc tccagtgggg acttcctgaa gtacaacttc accagtgccg
3181 tcaggcctga catccctgcc atggttttag aaaatggctg ccaggaaggc gtcgttgcct
3241 cagtcctcat caagagggct tctggcgaga tgctcgcctt ggcagtcagg atgggctcgc
3301 aggctgccat taagatcggc agtgctgtgg tgcacggaca gactggcatg ctcctgactg
3361 gctccaatgc caaggcccaa gatcttggga ccattccggg tgactgtggc tgcccctatg
3421 tttacaagaa aggaaacacc tgggttgtaa ttggagtgca cgtggcggcc accagatctg
3481 gcaacacggt cattgccgcc acccatggag aacccacact tgaagccttg gaatttcaag
3541 gtccccccat gctcccccgc ccaactggca cctatgcagg cctccccatc gctgattacg
3601 gcgatgcccc tcccctgagc accaaaacca tgttctggcg cacctcgccg gaaaagctcc
3661 ctcctggggc ctgggagcct gcctaccttg gctccaagga tgaaagagtg gatggccctt
3721 ccctacagca ggttatgcga gatcaactta agccctactc agagccgcgt ggcctgctcc
3781 ctccacagga gatcctggat gcggtttgcg atgccatcga gaaccgcctt gagaacaccc
3841 ttgaaccgca aaagccctgg acattcaaga aggcctgtga gagcctggac aagaacacca
3901 gcagtgggca cccctaccac aagcagaaga gtaaggactg gactgggacc gccttcattg
3961 gcgatcttgg tgaccaggcc acccatgcca acaacatgta tgagatgggt aaatccatgc
4021 ggcctgtcta cacagccgct ctcaaggatg agctggtcag gccagacaag atttacaaga
4081 agataaagaa aagacttctt tggggttctg atcttggcac catgatccgc gctgctcgcg
4141 cttttggccc cttttgtgat gcccttaaag agacctgcat tttcaaccct atcagagtgg
4201 gcatgtcaat gaacgaagat ggacccttca tcttcgcgag gcacgccaac ttcagatacc
4261 atatggatgc agactattct aggtgggact ccactcagca gagggccatc ctgaagcgcg
4321 ctggtgatat catggtgcgc ctctcccccg agccagagct ggcccgggtg gtgatggacg
4381 accttctggc cccctcgttg ctggacgtcg gcgactataa gattgtcgtc gaagaagggc
4441 tcccgtccgg ctgcccttgc accacgcaac tgaatagttt ggcccactgg atcctgaccc
4501 tctgtgcaat ggttgaggtg acccggattg accctgatat cgtgatgcaa gagtctgagt
4561 tttcctttta tggtgatgat gaggtggtct cgaccaacct cgaattggac atgaccaaat
4621 acaccatggc cctaagacgg tatggtctcc tcccgacgcg tgcggacaag gaagagggac
4681 ccctggagcg tcgccagacg ctgcagggca tctccttcct acgccgtgcg atagtcggtg
4741 accagtttgg ttggtacggc cgcctcgacc gtgccagcat tgaccgccag cttctttgga
4801 ctaaaggacc caaccatctg aatccttttg agactcttcc aggacatgcc cagagaccct
4861 cccaattgat ggccctgctc ggtgaggctg ccatgcatgg tgaaaagtat tacaggactg
4921 tggcttcccg ggtctccaag gaggccgccc atagtgggat agaaatggtg gtcccacgcc
4981 accggtctgt cctgcgctgg gtgcgcttcg gaacaatgga tgctgagacc ccgcaggaac
5041 gctcagcagt ctttgtgaat gaggatgagt gatggcgcag cgccaaaagc caacggctct
5101 gaagccagcg gccaggatct tgttcctacc gccgttgaac aggccgtccc cattcagccc
5161 gtggctggct cggctcttgc cgcccccgcc gccgggcaaa ttaaccaaat tgacccttgg
5221 atcttccaaa attttgtcca atgccccctt ggtgagtttt ccatttcacc tcgaaacacc
5281 ccaggtgaaa tactgtttga tctggccctc gggccagggc tcaaccccta ccttgcccac
5341 ctctcagcca tgtacaccgg ctgggttggg aacatggagg ttcagctggt cctcgccggc
5401 aatgccttta ctgctggcaa ggtggttgtt gcccttgtac caccctattt tcccaaaggg
5461 tcactcacca ctgctcagat cacatgcttc ccacatgtca tgtgtgatgt gcgcaccctg
5521 gagcccattc aactccctct tcttgacgtg cgtcgagttc tttggcatgc tacccaggat
5581 caggaggaat ctatgcgcct ggtctgcatg ctgtatacgc cactccgcac aaacagcccg
5641 ggtgatgagt cttttgtggt ctctggccgc cttctttcta agccggcagc tgatttcaac
5701 tttgtatacc tgaccccccc cattgagagg accatctacc ggatggtcga cttgcccgtg
5761 ctacagccgc ggctgtgcac gcacgctcgt tggccagccc cgatctatgg cctcttggtt
5821 gacccatccc tcccatccaa cccccaatgg cagaatggaa gagtgcatgt tgatggaacc
5881 ctccttggca caacacctgt ctctggatcc tgggtttcct gctttgcagc tgaggccgcc
5941 tacgagttcc aatccgggac tggtgaggtg gcaaccttca ccttgatcga gcaggatggg
6001 tccgcttatg tccctggtga cagagcggcc ccacttggct accccgattt ttctgggcaa
6061 ctggagatcg aggtgcagac tgagacgacc aagacaggtg ataagctgaa ggtgaccacc
6121 tttgagatga tccttggtcc cactaccaac gtggaccaag cgccctacca gggcagggtg
6181 tacgccagcc taacggctgt ggcctccctt gacctggttg atggcagagt tagggcggtt
6241 cctcgctcca tctatggctt tcaggatgtg atacctgagt ataatgatgg ccttcttgtc
6301 ccccttgccc ccccaattgg cccctttctc cctggtgagg ttctcctgag gttccggacc
6361 tacatgcgtc agcttgacac cgctgatgcc gcagcagagg caatagactg tgcactcccc
6421 caggagttca tttcctggtt cgcgtccaac gcgttcaccg tgcagtctga tgccctactc
6481 cttaggtata ggaacaccct gactggacag ctgctgtttg agtgcaagct ctacagcgag
6541 ggttacatcg ccctgtccta ctcggggtcg ggacccctca ctttcccaac tgatggcttc
6601 ttcgaggtcg tcagttgggt cccccgcctt tttcaattgg cctctgtggg aagcttgaca
6661 acaggccgaa cacttaaaca ataatggctg gtgccctttt tggagcaatt ggaggtggcc
6721 tgatgggcat aattggcaat tccatctcaa ctgtccagaa ccttcaggca aataaacaat
6781 tggctgcaca acaatttggt tataattctt ctttgcttgc aacgcaaatt caggcccaga
6841 aggatctcac attgatgggg cagcaattca atcagcagct ccaagccaac tctttcaagc
6901 atgaccttga gatgcttggc gcccaggtgc aagcccaggc gcaggcccag gagaacgcca
6961 tcaacatcag gtcggcgcag ctccaggccg caggcttttc aaagtcggat gccgtacgcc
7021 ttgcctcggg acagcagccc acgaagtccg tggactggtc tggtacgcgg tactacaccg
7081 ctaaccagcc agttacgggc ttctcaggtg gctttacccc aagttacact ccaggtaggc
7141 aaatgacatc tcgccctgtg gacacatccc ctctgccagt cttgggtgga cgcttgccct
7201 cccttcgtgg aggttcctgg tctccgcgtg attacacgcc ggcgactcaa ggcacctaca
7261 cgaatggacg gttcgtgtcc ctccccaaga ttgggagtag cagggcatag gttggaagag
7321 aaatctttct gtgaaaatga tttctgctta ctgcttcttt cttttagtag tatttagatg
7381 catttt
//
