KEGG   Geobacillus stearothermophilus: GT50_04745
Entry
GT50_04745        CDS       T04043                                 
Name
(GenBank) 2-isopropylmalate synthase
  KO
K01649  2-isopropylmalate synthase [EC:2.3.3.13]
Organism
gse  Geobacillus stearothermophilus
Pathway
gse00290  Valine, leucine and isoleucine biosynthesis
gse00620  Pyruvate metabolism
gse01100  Metabolic pathways
gse01110  Biosynthesis of secondary metabolites
gse01210  2-Oxocarboxylic acid metabolism
gse01230  Biosynthesis of amino acids
Module
gse_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:gse00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    GT50_04745
  09105 Amino acid metabolism
   00290 Valine, leucine and isoleucine biosynthesis
    GT50_04745
Enzymes [BR:gse01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.13  2-isopropylmalate synthase
     GT50_04745
SSDB
Motif
Pfam: HMGL-like LeuA_dimer Radical_SAM
Other DBs
NCBI-ProteinID: ALA69592
UniProt: A0A9W3R2P2
Position
complement(895122..896669)
AA seq 515 aa
MRKIKFFDTTLRDGEQSAGVNLNLQEKLEIARQLERLRVDIIEAGFPASSKGDFEAVKQI
AETVRTCSVTGLSRSVRSDIDAAWEALKGGAEPRLHLFIATSPIHMVHKLRMTPEQVIEA
AVEAVKYAKRFFPIVQWSAEDACRSELPFLAKIVAEVIKAGASVINIPDTVGYITPKEYG
EIFLYLQNNVPNIENVSLSAHCHDDLGMAVVNSLSAIEHGATQVECTINGIGERAGNAAL
EEIAVALHIRKDYYQVETRLNLQEIKRTSNLVSKLTGVVVPPNKAVVGKNAFAHESGIHQ
DGVLKEKTTYEIISPELVGVPSNSMVLGKHSGRHALRNRVEELGYTLSDEEINQLFVRFK
ELADKKKDITDDDLIALIFEEKFDHFKDFYQLSSIQVQYGTNQIPTAVVVLKDGKGNEIQ
EAATGAGSVEALYNTLERCFQTPVTLLDYRIESVGGGRDALAQVFVKVRAHDIETSGRGT
AQDVLEASAKAYINAINRVFMIEAMRGENEKVATP
NT seq 1548 nt   +upstreamnt  +downstreamnt
gtgcgaaaaattaagttttttgataccacattgcgtgacggggaacaatctgctggtgtg
aacttgaatttgcaagaaaagttggaaattgcccgtcagcttgaacggctgcgggttgac
atcatcgaggcgggtttccccgcctcatcgaaaggcgattttgaggcggtcaaacaaatc
gccgaaacggtgagaacatgctcggtcaccgggctgtcgcgctcggtccgaagcgacatt
gatgcggcgtgggaggcgttaaaaggcggcgcggagccgcggctccacctattcatcgcc
acctcgccgatccatatggtgcataaattgcggatgacgccggaacaagtgattgaagcg
gcggttgaggcggtgaaatacgcgaagcgctttttcccgattgtccaatggtcggcggaa
gatgcgtgccgaagcgagttgccgtttttggcgaaaatcgtcgccgaagtgatcaaagcc
ggcgcctcggtgatcaacattccggatacggtcggctatattacgccgaaagaatacggg
gaaattttcctctatttgcaaaacaatgttccgaatattgaaaatgtttcactctccgct
cattgtcatgatgacttgggcatggcggtggtgaactcgctatcggccattgaacatgga
gcgacacaggtcgagtgcacgatcaacggcatcggcgagcgggccggcaatgcggcgctt
gaggaaatcgctgtcgcccttcacatccgcaaagactactatcaagtggaaacgcgcctc
aatttgcaggaaattaagcgcacaagcaatcttgtcagcaagctgaccggggtcgtcgtt
ccacccaacaaagcggtcgtcggcaaaaatgcgtttgcgcatgaatcgggcatccatcaa
gacggcgtcttaaaagaaaaaacgacatacgaaatcatttcgccggagctcgtcggcgtg
ccgtcgaattcgatggtgctcggcaaacattccggccgccatgcgcttcgcaaccgggtt
gaggagctcggctacacgttgtccgatgaagaaatcaatcagctgtttgtccgttttaaa
gaattggcggacaaaaagaaggacattaccgacgatgatttaatcgcgttgattttcgaa
gagaagttcgaccactttaaagatttttaccaattgtcttccatccaagtgcaatacggg
acgaatcaaattccgacagcggtagttgtactgaaagacgggaaggggaatgaaatccaa
gaagcggcgaccggcgccggcagcgtcgaggcgctgtacaatacattggaacgttgcttc
caaacgccggtgacgctgcttgactaccggatcgaatcggtcggcggcggccgcgatgcg
ttggcccaagtgttcgtcaaagtgcgcgcccatgacatcgagacgagcgggcgcggcact
gcacaagacgtgttggaagcatcggcgaaagcgtacatcaacgccatcaaccgtgtgttt
atgatcgaagcgatgcgcggcgaaaacgagaaagtggcaacaccataa

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   OC (1)   
Protein sequence (1)   
   UniProt (1)   
Protein domain (3)   
   Pfam (3)   
All databases (24)   

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