KEGG   Heterocephalus glaber (naked mole-rat): 101711587
Entry
101711587         CDS       T02812                                 
Symbol
Ptk2
Name
(RefSeq) protein tyrosine kinase 2
  KO
K05725  focal adhesion kinase 1 [EC:2.7.10.2]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl01522  Endocrine resistance
hgl04012  ErbB signaling pathway
hgl04062  Chemokine signaling pathway
hgl04148  Efferocytosis
hgl04151  PI3K-Akt signaling pathway
hgl04360  Axon guidance
hgl04370  VEGF signaling pathway
hgl04510  Focal adhesion
hgl04670  Leukocyte transendothelial migration
hgl04810  Regulation of actin cytoskeleton
hgl04935  Growth hormone synthesis, secretion and action
hgl05100  Bacterial invasion of epithelial cells
hgl05135  Yersinia infection
hgl05146  Amoebiasis
hgl05163  Human cytomegalovirus infection
hgl05165  Human papillomavirus infection
hgl05170  Human immunodeficiency virus 1 infection
hgl05200  Pathways in cancer
hgl05202  Transcriptional misregulation in cancer
hgl05205  Proteoglycans in cancer
hgl05208  Chemical carcinogenesis - reactive oxygen species
hgl05222  Small cell lung cancer
hgl05417  Lipid and atherosclerosis
hgl05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    101711587 (Ptk2)
   04370 VEGF signaling pathway
    101711587 (Ptk2)
   04151 PI3K-Akt signaling pathway
    101711587 (Ptk2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    101711587 (Ptk2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    101711587 (Ptk2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    101711587 (Ptk2)
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    101711587 (Ptk2)
   04062 Chemokine signaling pathway
    101711587 (Ptk2)
  09152 Endocrine system
   04935 Growth hormone synthesis, secretion and action
    101711587 (Ptk2)
  09158 Development and regeneration
   04360 Axon guidance
    101711587 (Ptk2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101711587 (Ptk2)
   05202 Transcriptional misregulation in cancer
    101711587 (Ptk2)
   05205 Proteoglycans in cancer
    101711587 (Ptk2)
   05208 Chemical carcinogenesis - reactive oxygen species
    101711587 (Ptk2)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    101711587 (Ptk2)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    101711587 (Ptk2)
   05163 Human cytomegalovirus infection
    101711587 (Ptk2)
   05165 Human papillomavirus infection
    101711587 (Ptk2)
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    101711587 (Ptk2)
   05100 Bacterial invasion of epithelial cells
    101711587 (Ptk2)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101711587 (Ptk2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101711587 (Ptk2)
   05418 Fluid shear stress and atherosclerosis
    101711587 (Ptk2)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    101711587 (Ptk2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101711587 (Ptk2)
   01009 Protein phosphatases and associated proteins [BR:hgl01009]
    101711587 (Ptk2)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     101711587 (Ptk2)
Protein kinases [BR:hgl01001]
 Non-receptor tyrosine kinases
  FAK family
   101711587 (Ptk2)
Protein phosphatases and associated proteins [BR:hgl01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     101711587 (Ptk2)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Focal_AT Pkinase FERM_C_FAK1 FERM_N_2 FERM_M Kinase-like Haspin_kinase FERM_F2 ABC1
Other DBs
NCBI-GeneID: 101711587
NCBI-ProteinID: XP_004837947
Position
Un
AA seq 1106 aa
MLLELAGQESLKPAGAVYMEKSGCSPFPMCWAKEYDRYLASSKIMAAAYLDPNLNHTPNS
SAKTHLGTGMERSPCTMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHK
VKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQ
FTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEV
LEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKE
CFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFNQVQTIQYSHSEDKDRKGML
QLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGATQSFIIRPQKEGERALPSIPKL
ANNEKQGVRTHAVSMSETDDYAEIIDEEDTYTMPSKSYGIDEARDYEIQRERIELGRCIG
EGQFGDVHQGVYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGV
ITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAA
RNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFG
VCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRF
TELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGF
YPSPQHMVQANHYQVSGYPGSHGITAMPGSIYPGQASLLDQTESWNHRSQEIPMWQPNVE
DSAALDLRGIGQVLPAHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDG
SLQGLTGNQHIYQPVGKPDPAAPPKKPPRPGAPSHLGSLASLSSPGDSYNEGVKPWRLQP
QEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLA
TVDETIPVLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHA
LAVDAKNLLDVIDQARLKMLGQTRPH
NT seq 3321 nt   +upstreamnt  +downstreamnt
atgttgttggaactggcaggccaagagtccctgaaaccagcaggtgctgtctatatggag
aaaagcggctgtagtccatttccaatgtgttgggctaaagaatatgacagatacctagca
tctagcaaaataatggcagctgcttaccttgacccaaacttgaatcatacaccaaattca
agtgctaagactcacctgggtactggcatggaacgttccccttgtacaatggagcgagta
ttaaaagtctttcattattttgaaagcaatagtgagccaaccacctgggccagtattatc
aggcatggagatgcaactgatgtcaggggcatcattcagaagatagtggacagtcacaaa
gtaaagcacgtggcctgctatggattccgcctcagtcacctgcggtcagaggaggttcac
tggcttcatgtggacatgggtgtctccagtgtgagggagaagtatgagctcgcccaccca
ccagaggagtggaaatatgaactgagaattcgttatttgccaaaaggatttctaaaccag
tttactgaagacaagccaactctgaatttcttctatcaacaggtgaagagtgactacatg
ttagagatagctgaccaagtggaccaggaaattgctctgaagttgggttgtcttgaaata
cggcgatcatactgggagatgcggggcaatgcactagaaaagaagtctaactatgaagta
ttagaaaaagatgttggtttgaagcgattttttcctaagagtttactggattctgtcaag
gccaaaacactaagaaaactgatccaacaaacatttagacagtttgccaaccttaataga
gaagaaagtattctgaaattctttgagatcctctctccagtgtacagatttgacaaagaa
tgcttcaaatgtgcccttgggtcaagctggattatttcagtggaactggctatcggcccg
gaagaagggatcagttacctaacagacaaaggctgcaatcccacacatctggccgacttc
aaccaagtgcagaccattcagtattcacacagtgaagacaaggacagaaaaggaatgctg
cagctcaaaatagcaggtgctcctgagcctctcacagtgacggcaccatccctaaccata
gcagagaacatggctgacctgatagacggatactgtcgactagtgaatggagccacacag
tcctttatcatcagaccccagaaagaaggcgaacgggctttgccatcaattcccaagttg
gccaacaatgaaaagcagggtgtccgaacacatgctgtctccatgtcagagacagatgat
tatgctgagattatagatgaagaagacacttacaccatgccttcaaaaagctatggaata
gatgaagccagggattatgagattcagagagaaagaatagaacttggacgatgtattgga
gaaggccaatttggtgatgtacatcagggcgtgtatatgagtccagagaatccagctttg
gcagttgcaattaaaacatgtaaaaactgtacttcggacagcgtgagagagaaatttctt
caagaagccttaactatgcggcagtttgaccatcctcatattgtgaagctgattggagtc
atcacagagaatcctgtctggataataatggagctgtgcacacttggagagctgaggtca
tttttgcaagtgaggaaatacagcttggatctggcatctttgattctgtatgcctatcag
cttagtacagcacttgcatatttggagagcaaaagatttgtgcacagggacattgctgct
cgaaatgttctggtgtcctcaaatgattgtgtaaagttaggagactttgggttatcccga
tacatggaagacagtacttactacaaagcttccaaaggaaaattgcctattaaatggatg
gctccagagtcaatcaattttcgacgttttacctcagctagtgacgtatggatgtttggt
gtatgtatgtgggagatactgatgcatggtgtgaagccttttcaaggagtgaagaacaat
gatgtgatcggtcgaattgaaaatggggaaagattaccaatgcctccaaattgtcctcct
accctctacagccttatgacgaaatgctgggcctatgaccccagcaggcggcccaggttt
actgaacttaaagctcagctcagcacaatcctggaggaagagaaggcccagcaagaagaa
cgaatgaggatggagtcgagaagacaggccactgtgtcctgggactctggaggatctgat
gaagcaccacccaagcccagcagacctggttatcctagtccaaggtccagtgaaggattt
tatcccagtccgcagcacatggtgcaagccaatcattaccaggtctctggctaccctggt
tcacacggaatcacagctatgcctggcagcatctacccaggtcaggcatctctcttggac
cagacagagtcatggaatcatagatctcaagagatacccatgtggcagcccaacgtggag
gactcagcggccttggaccttcgcgggattgggcaggtcttgccagcccacctgatggaa
gagcggctgatccgacagcagcaggaaatggaagaagatcagcgctggttggaaaaagag
gagagatttctgaaacctgatgtgaggctctcacgaggcagcatcgacagggaggatggg
agtcttcagggtctgactggaaaccaacacatctatcagcctgtaggtaaaccagatcct
gcagctccaccaaagaaaccaccacgccctggagcccccagtcatctaggcagcctcgcc
agcctcagcagccctggggacagctacaatgagggtgttaagccatggaggcttcagccc
caggaaatcagccctcctcctactgccaacctggaccggtccaatgacaaggtgtatgag
aatgtgacgggcctggtgaaagctgtcatcgagatgtccagtaaaatccaaccagcccca
ccagaggagtatgttcctatggtgaaggaagttggcttggccctgcggacgttattggcc
acggtggatgagaccattcctgtcctcccagccagcacgcatcgagagatcgagatggcg
cagaagctgctgaactctgacttgggagagctcatcaacaagatgaagcttgcccagcaa
tacgtcatgaccagcctacagcaggagtacaagaagcagatgctgaccgcggctcatgcc
ctggctgtggatgccaaaaacctgcttgatgtcattgaccaagcaagactgaaaatgctt
gggcagacaagaccacactga

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (24)   
   KEGG PATHWAY (24)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (25)   
   RefSeq(pep) (25)   
DNA sequence (25)   
   RefSeq(nuc) (25)   
Protein domain (10)   
   Pfam (10)   
All databases (98)   

Download RDF
DBGET integrated database retrieval system