KEGG   Heterocephalus glaber (naked mole-rat): 101718432
Entry
101718432         CDS       T02812                                 
Symbol
Tnf
Name
(RefSeq) tumor necrosis factor
  KO
K03156  tumor necrosis factor superfamily, member 2
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl01523  Antifolate resistance
hgl04010  MAPK signaling pathway
hgl04060  Cytokine-cytokine receptor interaction
hgl04061  Viral protein interaction with cytokine and cytokine receptor
hgl04064  NF-kappa B signaling pathway
hgl04071  Sphingolipid signaling pathway
hgl04150  mTOR signaling pathway
hgl04210  Apoptosis
hgl04217  Necroptosis
hgl04350  TGF-beta signaling pathway
hgl04380  Osteoclast differentiation
hgl04612  Antigen processing and presentation
hgl04620  Toll-like receptor signaling pathway
hgl04621  NOD-like receptor signaling pathway
hgl04622  RIG-I-like receptor signaling pathway
hgl04625  C-type lectin receptor signaling pathway
hgl04640  Hematopoietic cell lineage
hgl04650  Natural killer cell mediated cytotoxicity
hgl04657  IL-17 signaling pathway
hgl04660  T cell receptor signaling pathway
hgl04664  Fc epsilon RI signaling pathway
hgl04668  TNF signaling pathway
hgl04920  Adipocytokine signaling pathway
hgl04930  Type II diabetes mellitus
hgl04931  Insulin resistance
hgl04932  Non-alcoholic fatty liver disease
hgl04933  AGE-RAGE signaling pathway in diabetic complications
hgl04936  Alcoholic liver disease
hgl04940  Type I diabetes mellitus
hgl05010  Alzheimer disease
hgl05014  Amyotrophic lateral sclerosis
hgl05020  Prion disease
hgl05022  Pathways of neurodegeneration - multiple diseases
hgl05132  Salmonella infection
hgl05133  Pertussis
hgl05134  Legionellosis
hgl05135  Yersinia infection
hgl05140  Leishmaniasis
hgl05142  Chagas disease
hgl05143  African trypanosomiasis
hgl05144  Malaria
hgl05145  Toxoplasmosis
hgl05146  Amoebiasis
hgl05152  Tuberculosis
hgl05160  Hepatitis C
hgl05161  Hepatitis B
hgl05163  Human cytomegalovirus infection
hgl05164  Influenza A
hgl05165  Human papillomavirus infection
hgl05166  Human T-cell leukemia virus 1 infection
hgl05168  Herpes simplex virus 1 infection
hgl05169  Epstein-Barr virus infection
hgl05170  Human immunodeficiency virus 1 infection
hgl05171  Coronavirus disease - COVID-19
hgl05205  Proteoglycans in cancer
hgl05310  Asthma
hgl05321  Inflammatory bowel disease
hgl05322  Systemic lupus erythematosus
hgl05323  Rheumatoid arthritis
hgl05330  Allograft rejection
hgl05332  Graft-versus-host disease
hgl05410  Hypertrophic cardiomyopathy
hgl05414  Dilated cardiomyopathy
hgl05417  Lipid and atherosclerosis
hgl05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101718432 (Tnf)
   04350 TGF-beta signaling pathway
    101718432 (Tnf)
   04064 NF-kappa B signaling pathway
    101718432 (Tnf)
   04668 TNF signaling pathway
    101718432 (Tnf)
   04071 Sphingolipid signaling pathway
    101718432 (Tnf)
   04150 mTOR signaling pathway
    101718432 (Tnf)
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    101718432 (Tnf)
   04061 Viral protein interaction with cytokine and cytokine receptor
    101718432 (Tnf)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    101718432 (Tnf)
   04217 Necroptosis
    101718432 (Tnf)
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    101718432 (Tnf)
   04620 Toll-like receptor signaling pathway
    101718432 (Tnf)
   04621 NOD-like receptor signaling pathway
    101718432 (Tnf)
   04622 RIG-I-like receptor signaling pathway
    101718432 (Tnf)
   04625 C-type lectin receptor signaling pathway
    101718432 (Tnf)
   04650 Natural killer cell mediated cytotoxicity
    101718432 (Tnf)
   04612 Antigen processing and presentation
    101718432 (Tnf)
   04660 T cell receptor signaling pathway
    101718432 (Tnf)
   04657 IL-17 signaling pathway
    101718432 (Tnf)
   04664 Fc epsilon RI signaling pathway
    101718432 (Tnf)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    101718432 (Tnf)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    101718432 (Tnf)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    101718432 (Tnf)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101718432 (Tnf)
   05170 Human immunodeficiency virus 1 infection
    101718432 (Tnf)
   05161 Hepatitis B
    101718432 (Tnf)
   05160 Hepatitis C
    101718432 (Tnf)
   05171 Coronavirus disease - COVID-19
    101718432 (Tnf)
   05164 Influenza A
    101718432 (Tnf)
   05168 Herpes simplex virus 1 infection
    101718432 (Tnf)
   05163 Human cytomegalovirus infection
    101718432 (Tnf)
   05169 Epstein-Barr virus infection
    101718432 (Tnf)
   05165 Human papillomavirus infection
    101718432 (Tnf)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    101718432 (Tnf)
   05135 Yersinia infection
    101718432 (Tnf)
   05133 Pertussis
    101718432 (Tnf)
   05134 Legionellosis
    101718432 (Tnf)
   05152 Tuberculosis
    101718432 (Tnf)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    101718432 (Tnf)
   05144 Malaria
    101718432 (Tnf)
   05145 Toxoplasmosis
    101718432 (Tnf)
   05140 Leishmaniasis
    101718432 (Tnf)
   05142 Chagas disease
    101718432 (Tnf)
   05143 African trypanosomiasis
    101718432 (Tnf)
  09163 Immune disease
   05310 Asthma
    101718432 (Tnf)
   05322 Systemic lupus erythematosus
    101718432 (Tnf)
   05323 Rheumatoid arthritis
    101718432 (Tnf)
   05321 Inflammatory bowel disease
    101718432 (Tnf)
   05330 Allograft rejection
    101718432 (Tnf)
   05332 Graft-versus-host disease
    101718432 (Tnf)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    101718432 (Tnf)
   05014 Amyotrophic lateral sclerosis
    101718432 (Tnf)
   05020 Prion disease
    101718432 (Tnf)
   05022 Pathways of neurodegeneration - multiple diseases
    101718432 (Tnf)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    101718432 (Tnf)
   05418 Fluid shear stress and atherosclerosis
    101718432 (Tnf)
   05410 Hypertrophic cardiomyopathy
    101718432 (Tnf)
   05414 Dilated cardiomyopathy
    101718432 (Tnf)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    101718432 (Tnf)
   04940 Type I diabetes mellitus
    101718432 (Tnf)
   04936 Alcoholic liver disease
    101718432 (Tnf)
   04932 Non-alcoholic fatty liver disease
    101718432 (Tnf)
   04931 Insulin resistance
    101718432 (Tnf)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101718432 (Tnf)
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    101718432 (Tnf)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides [BR:hgl04052]
    101718432 (Tnf)
   00536 Glycosaminoglycan binding proteins [BR:hgl00536]
    101718432 (Tnf)
Cytokines and neuropeptides [BR:hgl04052]
 Cytokines
  Tumor necrosis fators
   101718432 (Tnf)
Glycosaminoglycan binding proteins [BR:hgl00536]
 Heparan sulfate / Heparin
  Cytokines
   101718432 (Tnf)
SSDB
Motif
Pfam: TNF PD-C2-AF1
Other DBs
NCBI-GeneID: 101718432
NCBI-ProteinID: XP_004847074
UniProt: G5C3E2
Position
Un
AA seq 230 aa
MSTESMIRDVELAGEEPLQKAGGPQGSGRCWCLSFFSFLLVAGATTLFCLLHFGVIGPQR
GEFKDLNFFSPLFSTGSASQSGNDKPVAHVVANQQGQEKLEWLSKRANALLANGMDLTDN
QLVVPSDGLYLVYSQVLFKGQGCPSYVLLTHTVSRLAISYQDKVNLLSAIKSPCQKETPE
GAELKPWYEPVYLGGVFQLQKGDRLSAEVNLPDYLDFAESGQIYFGAIAL
NT seq 693 nt   +upstreamnt  +downstreamnt
atgagcacagaaagcatgatccgggacgtggagctcgctggggaggagcccctccagaag
gcagggggcccccagggctccgggcggtgctggtgcctcagcttcttctccttcctgctc
gtggcaggagccaccacgctcttctgcctgctgcacttcggggtgatcggcccccagcgg
ggagagtttaaggatctcaactttttctctcctctgttctccacaggatcagcttctcaa
agcgggaatgacaagcctgttgctcatgttgtagcaaaccaacaaggacaggagaagctg
gagtggctgagcaagcgtgccaatgccctcttggccaatggcatggatctaacggacaac
cagctggtggtgccttcggacgggctgtacctcgtctactcccaggtcctcttcaagggc
caaggctgcccctcctacgtcctcctcacccatactgtcagccgcctagccatctcctac
caggacaaggtcaacctcctgtctgccatcaagagtccctgccagaaggagaccccagag
ggggctgagctcaagccctggtatgagcccgtctacctgggaggggtcttccagctgcag
aagggagaccgcctcagtgccgaggtcaatctgcccgactatcttgacttcgcggagtcc
gggcagatctacttcggggccattgccctgtga

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (65)   
   KEGG PATHWAY (65)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (4)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (2)   
DNA sequence (2)   
   RefSeq(nuc) (2)   
Protein domain (2)   
   Pfam (2)   
All databases (84)   

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