KEGG   Heterocephalus glaber (naked mole rat): 101719464
Entry
101719464         CDS       T02812                                 

Gene name
Adcy4
Definition
(RefSeq) adenylate cyclase 4
  KO
K08044  adenylate cyclase 4 [EC:4.6.1.1]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
hgl00230  Purine metabolism
hgl01100  Metabolic pathways
hgl01522  Endocrine resistance
hgl04015  Rap1 signaling pathway
hgl04020  Calcium signaling pathway
hgl04022  cGMP-PKG signaling pathway
hgl04024  cAMP signaling pathway
hgl04062  Chemokine signaling pathway
hgl04072  Phospholipase D signaling pathway
hgl04114  Oocyte meiosis
hgl04211  Longevity regulating pathway
hgl04213  Longevity regulating pathway - multiple species
hgl04261  Adrenergic signaling in cardiomyocytes
hgl04270  Vascular smooth muscle contraction
hgl04371  Apelin signaling pathway
hgl04540  Gap junction
hgl04611  Platelet activation
hgl04713  Circadian entrainment
hgl04714  Thermogenesis
hgl04723  Retrograde endocannabinoid signaling
hgl04724  Glutamatergic synapse
hgl04725  Cholinergic synapse
hgl04727  GABAergic synapse
hgl04742  Taste transduction
hgl04750  Inflammatory mediator regulation of TRP channels
hgl04911  Insulin secretion
hgl04912  GnRH signaling pathway
hgl04913  Ovarian steroidogenesis
hgl04914  Progesterone-mediated oocyte maturation
hgl04915  Estrogen signaling pathway
hgl04916  Melanogenesis
hgl04918  Thyroid hormone synthesis
hgl04921  Oxytocin signaling pathway
hgl04923  Regulation of lipolysis in adipocytes
hgl04925  Aldosterone synthesis and secretion
hgl04926  Relaxin signaling pathway
hgl04927  Cortisol synthesis and secretion
hgl04928  Parathyroid hormone synthesis, secretion and action
hgl04934  Cushing syndrome
hgl04935  Growth hormone synthesis, secretion and action
hgl04970  Salivary secretion
hgl04971  Gastric acid secretion
hgl04972  Pancreatic secretion
hgl04976  Bile secretion
hgl05032  Morphine addiction
hgl05163  Human cytomegalovirus infection
hgl05166  Human T-cell leukemia virus 1 infection
hgl05200  Pathways in cancer
hgl05414  Dilated cardiomyopathy (DCM)
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    101719464 (Adcy4)
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    101719464 (Adcy4)
   04371 Apelin signaling pathway
    101719464 (Adcy4)
   04020 Calcium signaling pathway
    101719464 (Adcy4)
   04072 Phospholipase D signaling pathway
    101719464 (Adcy4)
   04024 cAMP signaling pathway
    101719464 (Adcy4)
   04022 cGMP-PKG signaling pathway
    101719464 (Adcy4)
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    101719464 (Adcy4)
  09144 Cellular community - eukaryotes
   04540 Gap junction
    101719464 (Adcy4)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    101719464 (Adcy4)
   04062 Chemokine signaling pathway
    101719464 (Adcy4)
  09152 Endocrine system
   04911 Insulin secretion
    101719464 (Adcy4)
   04923 Regulation of lipolysis in adipocytes
    101719464 (Adcy4)
   04912 GnRH signaling pathway
    101719464 (Adcy4)
   04913 Ovarian steroidogenesis
    101719464 (Adcy4)
   04915 Estrogen signaling pathway
    101719464 (Adcy4)
   04914 Progesterone-mediated oocyte maturation
    101719464 (Adcy4)
   04921 Oxytocin signaling pathway
    101719464 (Adcy4)
   04926 Relaxin signaling pathway
    101719464 (Adcy4)
   04935 Growth hormone synthesis, secretion and action
    101719464 (Adcy4)
   04918 Thyroid hormone synthesis
    101719464 (Adcy4)
   04928 Parathyroid hormone synthesis, secretion and action
    101719464 (Adcy4)
   04916 Melanogenesis
    101719464 (Adcy4)
   04925 Aldosterone synthesis and secretion
    101719464 (Adcy4)
   04927 Cortisol synthesis and secretion
    101719464 (Adcy4)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101719464 (Adcy4)
   04270 Vascular smooth muscle contraction
    101719464 (Adcy4)
  09154 Digestive system
   04970 Salivary secretion
    101719464 (Adcy4)
   04971 Gastric acid secretion
    101719464 (Adcy4)
   04972 Pancreatic secretion
    101719464 (Adcy4)
   04976 Bile secretion
    101719464 (Adcy4)
  09156 Nervous system
   04724 Glutamatergic synapse
    101719464 (Adcy4)
   04727 GABAergic synapse
    101719464 (Adcy4)
   04725 Cholinergic synapse
    101719464 (Adcy4)
   04723 Retrograde endocannabinoid signaling
    101719464 (Adcy4)
  09157 Sensory system
   04742 Taste transduction
    101719464 (Adcy4)
   04750 Inflammatory mediator regulation of TRP channels
    101719464 (Adcy4)
  09149 Aging
   04211 Longevity regulating pathway
    101719464 (Adcy4)
   04213 Longevity regulating pathway - multiple species
    101719464 (Adcy4)
  09159 Environmental adaptation
   04713 Circadian entrainment
    101719464 (Adcy4)
   04714 Thermogenesis
    101719464 (Adcy4)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    101719464 (Adcy4)
  09165 Substance dependence
   05032 Morphine addiction
    101719464 (Adcy4)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy (DCM)
    101719464 (Adcy4)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101719464 (Adcy4)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    101719464 (Adcy4)
   05163 Human cytomegalovirus infection
    101719464 (Adcy4)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    101719464 (Adcy4)
Enzymes [BR:hgl01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     101719464 (Adcy4)
SSDB
Motif
Pfam: Guanylate_cyc DUF1053 AC_N DUF3180 CD52
Other DBs
NCBI-GeneID: 101719464
NCBI-ProteinID: XP_004864137
Position
Un
AA seq 1120 aa
MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLVIVLCALLALLAVAWASGRELTSDPG
FLPTVLSALGGFLLLLGLASREQRLQRWTRPLSGLVWAALLALGQAFLFTGGVVSAWDQV
RWMAGKEWGNQHPGRLLCGPSASCALLQVSFFLFIIFTVYAMLPLGMWEAAAAGLTSSLS
HLLVLGLYLGPQPDSQPALLPQLAANAVLFLCGNVVGAYHKALMERALRATFREALSSLH
SRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSQPENTNNFHSLYVKRHQG
VSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKVPLHTRTHTPRSTNACGSKSW
GTVTTASLGFPSHCQTMPSTACAWGWTCAAPSGQLWKLRAATGVDINMRVGVHSGSVLCG
VIGLQKWQYDVWSHDVTLANHMEASGVPGRVHITGATLALLAGAYAVEDAAMEHRDPYLR
ELGEPTYLVIDPRAEEEDEKGTEGGLLFSLEGHKMRPSLLMTRYLESWGAAKPFAHLSHI
DSPVSTSTPLPEKALASFSPQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQS
KDFNLLTLYFREKEMEKQYRFSALPAFKYYTACTFLVFLSNFIIQMLVTNRPPALAFTYS
ITFLLFLLLLFVCFSEHLTWCVQKGPKMLHRLPALSGLVATWPGLRVALGTATILLVFTM
AIASLFFLPALADCPFQAPGVSSMDFNLSWELPGSLPLISVPYSMHCCVLGFLSCSLFLH
MSFELKLVLLLLWLVASCSVFLHSHAWLSDCLIAHLYPGSLDSSPGVLKEPKLMGAISFF
IFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQ
NRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK
FSGVEKIKTIGSTYMAATGLNATSGQDPQQDAERSCSHLGTMVEFAMALGSKLDVINKHS
FNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAQALQ
SLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG
NT seq 3363 nt   +upstreamnt  +downstreamnt
atggcccgcctcttcagcccccggccgccccccagcgaggacctcttctatgagacctac
tacagcctgagccagcaatacccgctgctgctcctgctgctcgtcatcgtgctctgcgcg
ctcctggcgctcctcgccgtggcctgggcgagcggcagggagctgacctcggacccaggc
ttccttcccacagtgttaagtgctttgggtggcttcttgctgctgctgggcctagcttcc
cgtgagcagcgactgcagcgctggacacgaccactgtctggccttgtgtgggctgcattg
ctggccctaggccaggccttcctgtttacagggggcgtcgtgagcgcctgggaccaggta
agatggatggcaggaaaggaatgggggaaccagcacccaggccgtttgctgtgtgggcct
tcagcttcctgcgccctgctccaggtgtcctttttcctcttcatcatcttcacggtgtat
gccatgctgcccctgggcatgtgggaggctgccgccgcaggtcttacctcctcactctcg
cacttgctggtcctcgggctgtaccttgggccacagccagactcccaacctgcactgctg
ccacagttggcagcaaatgcagtgctcttcctgtgcgggaatgtggtgggggcataccac
aaggcgctgatggagcgtgcgctgcgggccaccttccgggaggcactcagctccctgcac
tctcggcggagactggacacagagaaaaagcaccaggaacaccttctcttgtccatcctt
cctgcctacctggcccgagagatgaaagcagagatcatggcacggctgcaggccggacag
gggtcacagccagaaaacaccaataatttccacagcctctatgtgaagaggcaccaagga
gtcagtgtgttgtatgctgacatcgtgggcttcacgcggctggccagcgagtgctcccct
aaggagctggtgctcatgctcaatgagctcttcggcaagtttgaccagatcgccaaggtt
cctctacacacccgcacacacactcccaggagcacgaatgcatgcggatcaaaatcctgg
gggactgttactactgcgtctctgggcttcccctctcactgccagaccatgccatcaact
gcgtgcgcatggggctggacatgtgccgcgccatcaggtcagctctggaaacttcgggca
gccactggtgtggacataaacatgcgtgtgggagtgcactctggcagtgtactttgcgga
gtcatcgggctgcagaagtggcagtatgatgtctggtcccacgacgtcacactggccaac
cacatggaggcgagcggtgtgccaggtcgggtgcacatcacaggggctaccctggccctg
ctggcaggggcctatgctgtggaggatgcagccatggaacaccgagacccataccttcgg
gagctcggggagcctacatacctggtcattgatcctcgggctgaggaagaagatgagaag
ggcaccgaaggagggttactgttctctctggagggccacaagatgcgcccgtcactgctg
atgacacgctacctggagtcctggggtgcagccaagccttttgcccacctgagccacata
gacagccctgtgtccacctccactcctctcccggagaaggccctggcctccttcagcccc
cagtggagcctggaccggagcaggaccccccggggactagatgatgaactggacaccggg
gatgccaagttcttccaggtcatcgaacagctcaactctcagaaacagtggaagcagtcg
aaggacttcaacttactgacactgtacttcagagagaaggagatggagaaacagtatcgg
ttctctgctctccctgccttcaaatactatacagcctgcaccttcttggtttttctgtcc
aatttcatcatccaaatgctggtgacaaacaggcccccagctctggcctttacttacagc
atcaccttccttctcttccttctccttctcttcgtctgcttctcagagcacctgacgtgg
tgtgtccagaaaggccccaagatgctgcaccggctgcctgcactgtctggcctagtggcc
acatggcctggactgcgagtagccctgggcactgctaccatcctcctcgtcttcaccatg
gccattgccagcctgttcttcttaccagcattagcagactgccctttccaggcccctggt
gtgtcctccatggatttcaacctgtcctgggagctgcctgggtcactgcctctcatcagt
gtcccgtactccatgcactgctgtgtgctgggtttcctctcctgttccctctttctgcac
atgagctttgaattgaagctggtgctgctcctgctgtggctagtggcctcctgctccgtc
ttcctgcactcccacgcctggctgtcagactgcctcattgcccacctttatccgggctcc
ttggactccagcccaggagtgctgaaggaacccaagttgatgggagctatctccttcttc
atcttcttcttcaccctccttgtcctggctcggcagaatgaatattactgccgcctggac
ttcctgtggaagaagaaactgaggcaggagcgggaggagacagagacaatggagaacctg
acccggctgctcttggagaatgtgctgcctgcacatgtggccccgcagttcattggccag
aaccggcgcaatgaggacctctaccaccagtcctatgagtgtgtttgcgtgctctttgcc
tcagtcccagactttaaggagttttattctgaatccaacatcaaccatgaggggctagag
tgtctgcggctgctcaatgagataattgctgattttgatgagctgctctccaagcccaag
ttcagtggagtagagaagatcaaaactattggcagtacctacatggcagccacaggctta
aatgccacctctggacaagatccacaacaggatgctgaacggagctgcagccaccttggc
accatggtggaatttgcaatggccctggggtctaagctggatgtcatcaacaagcactca
tttaacaacttccgcctgcgtgtggggttgaatcatggaccagtagtggctggagtgatc
ggggcccagaagccacaatatgatatctggggcaacacagtgaatgtggccagtcgcatg
gagagcacaggagtccttggcaagatccaagtaactgaggagacagcccaggccctgcag
tccctgggctatacatgctacagtcggggtgtcatcaaggtcaaaggcaaaggacagctc
tgcacctacttcctgaacacagacttgacacgaactggacctccttccgccactctaggc
tga

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