KEGG   Heterocephalus glaber (naked mole-rat): 101725806
Entry
101725806         CDS       T02812                                 
Symbol
Erbb4
Name
(RefSeq) erb-b2 receptor tyrosine kinase 4
  KO
K05085  receptor tyrosine-protein kinase erbB-4 [EC:2.7.10.1]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl04010  MAPK signaling pathway
hgl04012  ErbB signaling pathway
hgl04020  Calcium signaling pathway
hgl04151  PI3K-Akt signaling pathway
hgl05014  Amyotrophic lateral sclerosis
hgl05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    101725806 (Erbb4)
   04012 ErbB signaling pathway
    101725806 (Erbb4)
   04020 Calcium signaling pathway
    101725806 (Erbb4)
   04151 PI3K-Akt signaling pathway
    101725806 (Erbb4)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    101725806 (Erbb4)
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    101725806 (Erbb4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:hgl01001]
    101725806 (Erbb4)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     101725806 (Erbb4)
Protein kinases [BR:hgl01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   101725806 (Erbb4)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Recep_L_domain GF_recep_IV Pkinase Furin-like TM_ErbB1 Kinase-like Haspin_kinase DUF3951 ABC1
Other DBs
NCBI-GeneID: 101725806
NCBI-ProteinID: XP_004851164
Position
Un
AA seq 1298 aa
MKLATGLWGWLSLLVAAGTVRPGASQSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVM
GNLEITSIEHNRDLSFLRSIREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIF
LNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPWPSNLTLVST
NGSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSG
PKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVD
SSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCT
KINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNL
VTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFST
INQRIVIRDNRKAENCTAEGMVCNQLCSSNGCWGPGPDQCLSCRRFSRGRICIESCNLYD
GELREFENGSVCVECDSQCEKMEEGLLTCHGPGPDNCTKCSHFKDGPNCVEKCPDGLQGA
NSFIFKYADQDRECHPCHPNCTQGCIGSTIEDCIGLMDRTPLIAAGVIGGLFILVIVGLT
FAVYVRRKSIKKKRALRRFLETELVEPLTPSGTAPNQAQLRILKETELKRIKVLGSGAFG
TVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSP
TIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEERRLVHRDLAARNVL
VKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKFTHQSDVWSYGVTI
WELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCWMIDADSRPKFKEL
AAEFSRMARDPQRYLVIQGDDRMKLPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNI
PPPIYTSRARIDSNRSEIGHSPPPAYTPMSGNQFVYRDGGFAPEQGMPVPYRATTSTIPE
APVAQGAAAEIFDDSCCNGTLRKPVVPHAQEDSSTQRYSADPTLFAPERSPRGELDEEGY
MTPMRDKPKQEYLNPVEENPFVSRRKNGDLQALDNPEYHNASNGPPKAEDEYVNEPLYLN
TFANALGNAEYLKNSVLSVPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQ
NGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV
NT seq 3897 nt   +upstreamnt  +downstreamnt
atgaagctggcgacgggattgtggggctggctgagcctcctcgtggcggcgggaaccgtc
cggcccggcgcttctcagtcagtgtgtgcaggaacagaaaataaactgagctctctctca
gacctggaacagcagtaccgagccttacgaaaatactatgagaactgtgaggtggtcatg
ggcaacctggagatcaccagtatagagcacaaccgggatctctccttcctgcggtctatc
cgagaagtcaccggctatgtattagtggctcttaaccagtttcgttacctgcctttggag
aatttacggattattcgtgggacaaaactttatgaagatagatatgctttggcaatattt
ctaaactacaggaaagatggaaacttcggacttcaggaacttggattaaagaacttgaca
gaaattctaaatgggggcgtctatgtagaccagaacaagttcctttgttatgcagacact
attcattggcaagatattgttcggaatccatggccttccaacttgactctggtatcaaca
aatggaagctccggatgtggacgctgccacaagtcttgcacaggccgatgctggggacct
acagaaaatcactgccagactttgacgaggacagtgtgtgcagagcagtgcgatgggaga
tgctatggaccctatgtcagcgactgttgccatcgggaatgcgctggaggctgctctgga
cctaaggacacagactgttttgcctgcatgaatttcaatgacagcggagcttgtgtcact
cagtgtccccagacctttgtctacaatccaaccacctttcagctggagcacaacttcaat
gccaagtacacatatggagcattctgtgtcaagaaatgtccacataactttgtggtagat
tccagttcatgtgtacgtgcctgccctagttccaagatggaagtagaagaaaatgggatt
aagatgtgtaaaccttgcactgatatctgcccaaaagcttgtgatggcattggcacagga
tcactgatgtcagctcagactgtggactccagtaacatcgacaagttcatcaactgcaca
aagatcaatgggaatctgatcttccttgtcactggtattcacggggatccttacaatgca
attgaagctattgacccagaaaaactgaatgtctttcggacagtcagagagataacaggt
ttcttgaacatacaatcatggcctccaaatatgactgacttcagtgttttctctaacctg
gtgaccattggtgggagagtactctacagtggcctctccctgctgatcctcaagcaacaa
ggtattacctctctgcagtttcagtccttgaaggaaatcagtgcaggaaatatctacatc
actgacaacagcaacctgtgttattatcacaccattaattggacgacactcttcagcaca
atcaaccaaagaatagtgattcgggataatagaaaagctgagaattgtactgcagaagga
atggtgtgtaaccagctgtgttctagcaatggctgttggggacctgggccagaccagtgc
ctgtcctgccgccggttcagcagaggacggatctgcatagagtcttgtaacctctatgat
ggtgaacttcgggagttcgagaatggctctgtctgcgtggagtgtgactcccagtgtgag
aagatggaagagggcctcctcacgtgccatgggccaggacctgacaactgcacaaagtgc
tctcattttaaagatggcccaaactgtgtggaaaagtgtccagacggcttacagggggca
aacagcttcattttcaagtatgcggatcaggatcgggagtgccatccctgccacccaaac
tgcacccaagggtgcataggctcgactattgaagactgcatcggcctgatggatagaact
cccctgattgctgctggagtcattggtgggctcttcatcctggtcatagtgggtctgaca
tttgcagtttatgttaggaggaagagcatcaaaaagaaaagagccttaagaagatttcta
gaaacagagttggtagaacccttaactcctagtggcacagcacccaatcaagctcaactt
cgtattttgaaagaaactgaactaaagaggataaaagtccttggctcaggtgcttttgga
actgtttataaaggtatttgggttcctgaaggagaaacagtgaagattcctgtagctatt
aagattctcaatgagacaactggtcccaaggccaatgtggagttcatggatgaagctcta
atcatggcaagtatggaccatccacatctagttcgcttactgggtgtgtgtctgagccca
accatccagctggttacacagcttatgccccatggctgcctgctggattatgtccatgaa
cacaaggataatatagggtcacagctgctgctaaattggtgtgtacagatagctaaggga
atgatgtacctcgaagaaagacgacttgtccatcgggatttggcagcccgtaatgtctta
gtgaaatctccaaatcatgtgaagatcacagattttggactagccagactcttggaagga
gatgaaaaagagtataatgctgatggaggaaagatgccaattaagtggatggctctggag
tgtatacattataggaaattcactcatcagagtgacgtctggagctacggagtcactata
tgggaactgatgacctttgggggaaaaccctatgatggaattccaacccgagaaatccct
gacttattagagaaaggagaacgtttgcctcagcctcccatctgcactattgatgtttac
atggtcatggtcaaatgttggatgattgatgcggacagtagacctaaattcaaggaactg
gctgctgaattctcaaggatggctcgcgaccctcagagatatctagttattcagggtgac
gatcgtatgaagcttcccagtccaaatgacagcaagttctttcagaatctcttggacgaa
gaggatttggaagatatgatggatgctgaggaatatctggtcccccaggctttcaacatc
cctcctcccatctacacttccagggccagaattgactcaaacaggagtgaaattggacac
agccctcctcctgcctacacccccatgtcaggaaaccagtttgtgtacagagatggggga
tttgctccagaacaaggcatgcctgtgccatacagagccacaaccagcaccatcccagaa
gctccagttgcccaaggtgctgctgctgagatttttgatgactcctgctgtaatggcacc
ctacgcaagccagtggtaccccatgcccaagaggacagcagcacccagaggtacagcgct
gaccccacattgtttgccccagaacggagtccaagaggagaactggatgaagaaggctac
atgactcctatgcgagacaaacccaaacaagaatacctgaatcccgtggaggagaaccct
tttgtgtctcggagaaaaaatggagaccttcaagctttggataatcctgagtaccacaat
gcttccaatggtccacccaaggcagaggatgagtatgtgaatgagccattatacctcaac
acctttgccaatgccttggggaatgctgagtatctgaagaacagtgtactgtctgtgcca
gagaaggccaaaaaagcatttgacaaccctgactactggaaccacagcctgccacctcga
agcaccctccagcacccagactacctgcaggagtacagcacaaaatatttttataaacag
aatggacggatccggcctattgtggcagagaatcctgaatacctctctgagttctcactg
aagccaggcactgtgctgcctcctccaccctacagacaccggaatactgtggtgtaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (21)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   OC (1)   
Protein sequence (5)   
   RefSeq(pep) (5)   
DNA sequence (9)   
   RefSeq(nuc) (5)   
   GenBank (2)   
   EMBL (2)   
Protein domain (10)   
   Pfam (10)   
All databases (60)   

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