KEGG   Homo sapiens (human): 23395
Entry
23395             CDS       T01001                                 
Symbol
LARS2, HLASA, LEURS, PRLTS4, mtLeuRS
Name
(RefSeq) leucyl-tRNA synthetase 2, mitochondrial
  KO
K01869  leucyl-tRNA synthetase [EC:6.1.1.4]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00970  Aminoacyl-tRNA biosynthesis
Disease
H02095  Perrault syndrome
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09120 Genetic Information Processing
  09122 Translation
   00970 Aminoacyl-tRNA biosynthesis
    23395 (LARS2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes [BR:hsa01007]
    23395 (LARS2)
  09182 Protein families: genetic information processing
   03016 Transfer RNA biogenesis [BR:hsa03016]
    23395 (LARS2)
   03029 Mitochondrial biogenesis [BR:hsa03029]
    23395 (LARS2)
Enzymes [BR:hsa01000]
 6. Ligases
  6.1  Forming carbon-oxygen bonds
   6.1.1  Ligases forming aminoacyl-tRNA and related compounds
    6.1.1.4  leucine---tRNA ligase
     23395 (LARS2)
Amino acid related enzymes [BR:hsa01007]
 Aminoacyl-tRNA synthetase
  Class I (U)
   23395 (LARS2)
Transfer RNA biogenesis [BR:hsa03016]
 Eukaryotic type
  Aminoacyl-tRNA synthetases (AARSs)
   Multi-aminoacyl-tRNA synthetase complex (MSC)
    23395 (LARS2)
 Prokaryotic type
    23395 (LARS2)
Mitochondrial biogenesis [BR:hsa03029]
 Mitochondrial DNA transcription, translation, and replication factors
  Mitochondrial transcription and translation factors
   Other mitochondrial DNA transcription and translation factors
    23395 (LARS2)
SSDB
Motif
Pfam: tRNA-synt_1 tRNA-synt_1g Anticodon_1 tRNA-synt_1_2 tRNA-synt_1e tRNA-synt_1f
Other DBs
NCBI-GeneID: 23395
NCBI-ProteinID: NP_056155
OMIM: 604544
HGNC: 17095
Ensembl: ENSG00000011376
UniProt: Q15031
Position
3:45388576..45549407
AA seq 903 aa
MASVWQRLGFYASLLKRQLNGGPDVIKWERRVIPGCTRSIYSATGKWTKEYTLQTRKDVE
KWWHQRIKEQASKISEADKSKPKFYVLSMFPYPSGKLHMGHVRVYTISDTIARFQKMRGM
QVINPMGWDAFGLPAENAAVERNLHPQSWTQSNIKHMRKQLDRLGLCFSWDREITTCLPD
YYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVDEHGCSWRSGAKVEQKYLRQ
WFIKTTAYAKAMQDALADLPEWYGIKGMQAHWIGDCVGCHLDFTLKVHGQATGEKLTAYT
ATPEAIYGTSHVAISPSHRLLHGHSSLKEALRMALVPGKDCLTPVMAVNMLTQQEVPVVI
LAKADLEGSLDSKIGIPSTSSEDTILAQTLGLAYSEVIETLPDGTERLSSSAEFTGMTRQ
DAFLALTQKARGKRVGGDVTSDKLKDWLISRQRYWGTPIPIVHCPVCGPTPVPLEDLPVT
LPNIASFTGKGGPPLAMASEWVNCSCPRCKGAAKRETDTMDTFVDSAWYYFRYTDPHNPH
SPFNTAVADYWMPVDLYIGGKEHAVMHLFYARFFSHFCHDQKMVKHREPFHKLLAQGLIK
GQTFRLPSGQYLQREEVDLTGSVPVHAKTKEKLEVTWEKMSKSKHNGVDPEEVVEQYGID
TIRLYILFAAPPEKDILWDVKTDALPGVLRWQQRLWTLTTRFIEARASGKSPQPQLLSNK
EKAEARKLWEYKNSVISQVTTHFTEDFSLNSAISQLMGLSNALSQASQSVILHSPEFEDA
LCALMVMAAPLAPHVTSEIWAGLALVPRKLCAHYTWDASVLLQAWPAVDPEFLQQPEVVQ
MAVLINNKACGKIPVPQQVARDQDKVHEFVLQSELGVRLLQGRSIKKSFLSPRTALINFL
VQD
NT seq 2712 nt   +upstreamnt  +downstreamnt
atggcttctgtttggcagagattgggtttttatgcctctcttctgaaaagacagctaaat
ggtgggccagatgtcatcaagtgggaaaggagagtaattcccggatgtaccagaagcatc
tacagtgccacgggaaagtggacaaaagagtatacattgcagacaagaaaggatgttgag
aaatggtggcatcaacgaataaaagaacaggcctccaaaatttcagaagctgataaatcg
aagccaaaattttacgtgctttccatgttcccttatccttctggtaagctgcacatgggc
catgtgcgtgtctacaccatcagcgacaccatagcacggttccagaagatgagagggatg
caggtcatcaaccccatgggatgggatgcttttggattgcctgctgaaaatgccgcagtc
gagaggaatctacatccacaaagttggacacaaagtaatattaaacacatgaggaaacag
cttgatcgtctgggcctgtgtttcagctgggatagggaaataactacgtgtttgccagat
tactacaagtggactcagtatctctttattaaactgtatgaggctgggctggcctatcaa
aaggaggccctggttaactgggacccagtggatcaaacagtgcttgccaatgagcaggtg
gatgaacatggctgttcatggcgttctggagcaaaggtggaacagaagtacctcagacaa
tggtttattaagacaaccgcttatgcaaaggccatgcaggacgcgttggcagaccttcca
gaatggtatggaataaaaggcatgcaagcccactggattggggactgtgtgggctgccac
ctggacttcacattaaaggttcatgggcaagccacgggcgaaaagctgactgcctatacg
gccacccctgaagccatttatggcacctcccacgtggccatctcgcccagccacagactc
ctacatgggcacagctctctgaaggaagccttgaggatggcccttgtccctggcaaagat
tgcctcacgcctgtaatggctgtgaacatgcttacccagcaggaggtccctgtcgttatt
ttggccaaagctgacttggaaggctctctggattcaaaaataggaattcccagtactagc
tcagaggacaccatcttagcccaaaccctgggcctggcctactctgaagtcattgaaact
ttgccagatggcacagagagactgagcagctctgctgagttcacaggtatgacccggcag
gatgcttttctagccctgactcagaaagcccgggggaagagagtgggtggagacgtgaca
agtgataaactgaaagactggctgatttcacggcagcggtactggggcacaccaatcccc
attgtccactgcccagtctgtggccccacacctgtgcccctggaggacttgcctgtgacc
ctgcccaacatcgcgtctttcactggcaagggaggccccccactggccatggcttcagag
tgggtgaactgctcctgcccaaggtgcaagggagcagccaagagagagacagacacgatg
gatacctttgttgattctgcttggtactacttcagatacactgaccctcataatccacac
agcccttttaacacagcagtggccgattactggatgcctgtggatttgtacattggaggg
aaagaacatgccgtcatgcacttgttctatgcaagattctttagtcatttttgccatgat
caaaaaatggttaaacatagggagccttttcataagctgctggcccaaggccttatcaag
gggcagacattccgcctaccatctggacagtatctacagagagaggaagtggatctcaca
ggttccgttcctgttcatgcaaaaacgaaagagaagttagaggtgacgtgggagaagatg
agtaagtccaaacacaacggggtggacccagaggaagttgtggagcagtatgggatcgac
acgattcggctctacatcctttttgctgcccctcctgagaaggatatcttgtgggatgtg
aaaactgatgctctccctggggtgctgagatggcaacaacgactgtggaccttgacaact
cggtttattgaggccagggcttctgggaagtctccccagcctcagctgctgagtaacaag
gagaaagctgaggccaggaagctctgggagtacaagaactccgtcatctctcaggtgacc
acccatttcacagaggacttctcactgaattctgcaatttctcagctgatgggactcagc
aatgccctctcgcaagcctctcagagcgtcattctccacagccccgagtttgaggatgct
ttgtgtgccctgatggtaatggctgctccactggcccctcatgtaacctcagagatctgg
gcaggcctggcgctggtgccgaggaagctctgtgcccactacacttgggatgccagtgtg
ctgctccaggcatggcctgctgtggacccggagttcctgcagcagcctgaggttgtccag
atggcagttctgatcaacaataaagcttgtggcaaaattcctgtgccccaacaagttgcc
cgggaccaggacaaagtccacgaatttgttcttcaaagcgagctgggtgtcaggcttttg
caaggacgaagcatcaagaagtccttcctttccccgagaactgccctcatcaacttcctg
gtgcaagattga

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (4)   
   KEGG DISEASE (1)   
   OMIM (3)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   HGNC (1)   
   Ensembl (1)   
   RIKEN BRC-DNA (1)   
   OC (1)   
Protein sequence (12)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (10)   
DNA sequence (22)   
   RefSeq(nuc) (10)   
   GenBank (6)   
   EMBL (6)   
Protein domain (6)   
   Pfam (6)   
All databases (72)   

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