PATHWAY: hsa00230 Help
Entry
Name
Purine metabolism - Homo sapiens (human)
Class
Metabolism; Nucleotide metabolism
BRITE hierarchy
Pathway map
Ortholog table
Module
hsa_M00053 Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:hsa00230 ]
Network
Element
N01418 Purine salvage pathway, adenine to AMP
N01420 APRT deficiency in adenine metabolism
N01421 Purine salvage pathway, hypoxanthine/guanine to IMP/GMP
N01423 HPRT1 deficiency in hypoxanthine metabolism
N01424 HPRT1 deficiency in guanine metabolism
N01627 Adenosine phosphorylation
Drug
D00155 Pentostatin (JAN/USAN/INN)
D00224 Allopurinol (JP18/USP/INN)
D00417 Milrinone (JAN/USP/INN)
D00752 Mycophenolate mofetil (JAN/USP)
D01155 Gemcitabine hydrochloride (JAN/USP)
D01206 Febuxostat (JP18/USAN/INN)
D01370 Cladribine (JAN/USP/INN)
D01896 Cilostazol (JP18/USP/INN)
D01907 Fludarabine phosphate (JAN/USP)
D02008 Tadalafil (JAN/USP/INN)
D02042 Olprinone hydrochloride hydrate (JAN)
D02084 Inamrinone ethylenelactate
D02933 Anagrelide hydrochloride (USP)
D03546 Clofarabine (JAN/USAN/INN)
D03828 Pemetrexed disodium (USAN)
D04245 Forodesine hydrochloride (JAN/USAN)
D04508 Imazodan hydrochloride (USAN)
D04628 Isomazole hydrochloride (USAN)
D04751 Lixazinone sulfate (USAN)
D04766 Lometrexol sodium (USAN)
D05094 Mycophenolate mofetil hydrochloride (USAN)
D05095 Mycophenolate sodium (USP)
D05096 Mycophenolic acid (USAN/INN)
D06503 Pemetrexed sodium hydrate (JAN)
D09622 Gisadenafil besylate (USAN)
D10222 Gemcitabine elaidate (USAN/INN)
D10255 Anagrelide hydrochloride hydrate (JAN)
D10432 Ulodesine succinate (USAN)
D10596 Pemetrexed sodium hemipentahydrate (JAN)
D10976 Recanaclotide (USAN/INN)
D11017 Elapegademase (USAN/INN)
D11081 Febuxostat hydrate (JAN)
D11352 Pemetrexed tromethamine (USAN)
D12203 Tovinontrine (USAN/INN)
D12373 Quemliclustat (USAN/INN)
D12387 Fosgemcitabine palabenamide (USAN/INN)
D13001 Edelinontrine (USAN/INN)
Other DBs
Organism
Homo sapiens (human) [GN:
hsa ]
Gene
2618 GART; phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase [KO:K11787 ] [EC:6.3.4.13 2.1.2.2 6.3.3.1 ]
10606 PAICS; phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase [KO:K01587 ] [EC:4.1.1.21 6.3.2.6 ]
471 ATIC; 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase [KO:K00602 ] [EC:2.1.2.3 3.5.4.10 ]
956 ENTPD3; ectonucleoside triphosphate diphosphohydrolase 3 [KO:K01510 ] [EC:3.6.1.5 ]
953 ENTPD1; ectonucleoside triphosphate diphosphohydrolase 1 [KO:K01510 ] [EC:3.6.1.5 ]
9583 ENTPD4; ectonucleoside triphosphate diphosphohydrolase 4 [KO:K12305 ] [EC:3.6.1.6 ]
957 ENTPD5; ectonucleoside triphosphate diphosphohydrolase 5 (inactive) [KO:K01511 ] [EC:3.6.1.6 ]
955 ENTPD6; ectonucleoside triphosphate diphosphohydrolase 6 [KO:K01511 ] [EC:3.6.1.6 ]
50484 RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B [KO:K10808 ] [EC:1.17.4.1 ]
954 ENTPD2; ectonucleoside triphosphate diphosphohydrolase 2 [KO:K01509 ] [EC:3.6.1.-]
646625 URAD; ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase [KO:K13485 ] [EC:4.1.1.97 ]
Compound
C00053 3'-Phosphoadenylyl sulfate
C00054 Adenosine 3',5'-bisphosphate
C00119 5-Phospho-alpha-D-ribose 1-diphosphate
C00620 alpha-D-Ribose 1-phosphate
C00655 Xanthosine 5'-phosphate
C01228 Guanosine 3',5'-bis(diphosphate)
C01260 P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261 P1,P4-Bis(5'-guanosyl) tetraphosphate
C03373 Aminoimidazole ribotide
C03483 Adenosine tetraphosphate
C03614 Inosine 5'-tetraphosphate
C03794 N6-(1,2-Dicarboxyethyl)-AMP
C03838 5'-Phosphoribosylglycinamide
C04051 5-Amino-4-imidazolecarboxyamide
C04376 5'-Phosphoribosyl-N-formylglycinamide
C04392 P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494 Guanosine 3'-diphosphate 5'-triphosphate
C04640 2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734 1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751 1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823 1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05515 5-Ureido-4-imidazole carboxylate
C05516 5-Amino-4-imidazole carboxylate
C06196 2'-Deoxyinosine 5'-phosphate
C06197 P1,P3-Bis(5'-adenosyl) triphosphate
C06433 5'-Benzoylphosphoadenosine
C06435 5'-Butyrylphosphoinosine
C12248 5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395 N6-Succino-2-amino-2'-deoxyadenylate
Reference
Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
Journal
Reference
Authors
Xi H, Schneider BL, Reitzer L.
Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
Journal
Related pathway
hsa00250 Alanine, aspartate and glutamate metabolism
hsa00260 Glycine, serine and threonine metabolism
hsa00630 Glyoxylate and dicarboxylate metabolism
KO pathway